| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
At the active site of enzymes, reactive species that are very unstable in artificial systems sometimes play crucial roles in chemical transformations. Such fabulous features of enzymatic reactions are highly associated with the geometrically isolated environments at the active sites. For modeling such an isolated environment of enzymes with synthetic systems, novel nano-sized molecular cavities incorporating highly reactive amino-acid derivatives have been developed and applied to stabilization of reactive intermediates of biological reactions. By utilizing the novel model system, chemical processes that have been proposed for the catalytic mechanism of selenoenzymes such as glutathione peroxidase have been demonstrated experimentally.
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