Development of Metal Complexes with High Catalytic Efficiency Using Unique Ligand Effects
| Project/Area Number |
15H03802
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 触媒的不斉合成 / 不斉水素化反応 / 不斉異性化反応 / 不斉シアノ化反応 / 部分水素化反応 / ルテニウム錯体 / エナンチオ選択性 / ナノ粒子 / 合成化学 / 触媒・化学プロセス / 不斉合成 / 分子認識 / 有機工業化学 |
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| Outline of Final Research Achievements |
1) A novel chiral Ru catalyst precisely controlled chemoselectivity in the asymmetric hydrogenation of γ- and δ-keto esters into the hydroxyl esters (lactones) or diols by changing the reaction conditions. The enantioselectivity reached 99%. 2) Asymmetric hydrogenation of aromatic N-benzylimines catalyzed by a Ru complex afforded the chiral amines in up to 95% ee. 3) A Ru-catalyzed asymmetric isomerization of allylic alcohols into the chiral aldehydes achieved turnover number (TON) of >1000 and optical yield of >99%. 4) Asymmetric cyanation of alkynyl ketones and alkynyl imino esters with chiral Ru-Li combined catalysts gave the corresponding cyanated products in up to 97% ee. The TON of this reaction reached 2000. 5) Newly devised Pd nanoparticles catalyzed semihydrogenation of alkynes into the (Z)-alkenes in homogeneous phase. The TON of 20,000 and the selectivity of 99% were achieved.
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Report
(4 results)
Research Products
(54 results)
