Asymmetric Synthesis of Chiral Transition-Metal Complexes by Stereoselective Organic Reactions and Their Application
| Project/Area Number |
15H03805
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
Ogasawara Masamichi 徳島大学, 大学院社会産業理工学研究部(理工学域), 教授 (70301231)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 保 北海道大学, 触媒科学研究所, 教授 (30163273)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 面不斉 / オレフィン・メタセシス / 不斉合成 / 均一系触媒 / メタロセン / 非対称化 / 不斉配位子 / 有機触媒 / 遷移金属錯体 / 速度論分割 / フェロセン / シマントレン / ホスホール / ピリドン / エナンチオ選択的 / ジアステレオ選択的 |
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| Outline of Final Research Achievements |
The purposes of this research project is development of novel enantioselective synthetic methods of various chiral transition-metal complexes utilizing well-developed stereoselective organic transformations. The target complexes in this study are potential chiral catalysts, and thus, application of the products in the subsequent "second" asymmetric reactions as chiral catalysts or chiral ligands was also examined. The stereoselective organic transformations used in this study are mainly transition-metal-catalyzed asymmetric reactions, but other stoichiometric asymmetric processes are also used. Through this study, we have successfully established multiple methods of preparing various planar-chiral transition-metal complexes in highly enantiomerically enriched forms.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Atropisomeric chiral diiododienes, (Z,Z)-2,3-di(1-iodoalkylidene)tetralins: Synthesis, enantiomeric resolution, and application in asymmetric catalysis2017
Author(s)
M. Ogasawara, H. Sasa, H. Hu, Y. Amano, H. Nakajima, N. Takenaga, K. Nakajima, Y. Kita, T. Takahashi, T. Dohi
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Journal Title
Org. Lett.
Volume: 19
Issue: 15
Pages: 4102-4105
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bithiophene with Winding Vine-Shaped Molecular Asymmetry: Preparation, Structural Characterization, and Enantioselective Synthesis2016
Author(s)
Toyomori, Y.; Tsuji, S.; Mitsuda, S.; Okayama, Y.; Mori, A.; Kobayashi, T.; Miyazaki, Y.; Yaita, T.; Arae, S.; Takahashi, T.; Ogasawara, M.
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Journal Title
Bull. Chem. Soc. Jpn.
Volume: 89
Issue: 12
Pages: 1480-1486
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Catalytic Enantioselective Synthesis of P-Stereogenic Phosphine Derivatives by Mo-Catalyzed Asymmetric Ring-Closing Metathesis on (π-Arene)chromium Platform2015
Author(s)
Ogasawara, M.; Ikehata, R.; Tseng, Y.-Y.; Wu, W.-Y.; Yasuda, R.; Arae, S.; Takahashi, T.; Kamikawa, K.
Organizer
The 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
Place of Presentation
リーガロイヤルホテル, Kyoto, Japan
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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