| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
New synthetic reactions utilizing small ring hydrocarbons with hetero substituents were developed. A bicyclo[4.2.0]octane derivative was synthesized on the basis of the intramolecular cyclization reaction of a vinyl sulfide possessing a leaving group. A new divinylcyclobutane rearrangement reaction was developed by using 2,2-divinylcyclobutanecarbonitrile as a useful building block. The adduct derived from the four-membered nitrile and a cyclohexanone derivative was treated with an acid, giving rise to a bicyclo[6.4.0]undecane derivative via the Cope rearrangement.
On the other hand, squarate dianion was found to exhibit high reactivity as an oxygen nucleophile, which enabled the transformation of primary and secondary chlorides and bromides to the corresponding alcohols in high yields.
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