| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
In organic synthesis, it is important to develop new catalytic reaction providing useful optically active compounds. We have developed new nitrogen-based multidentate ligands for asymmetric catalysis. As N,C,N-type or N,N,O-type ligands, bis(oxazolinyl)phenyl or binaphthol-phenanthroline derivatives were examined to show high stereoselectivity and enantioselectivity for asymmetric conjugate silylation of substituted cyclohexadienones, conjugate addition and susequent alkylation, α－oxidation of oxindole skeleton etc., in the combination with a variety of metals. Plausible catalytic cycles including intermediate or transition state were examined by theoretical calculation to give the corresponding structures for asymmetric conjugate hydrosilylation.
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