Developmen of Catalytic Decarboxylation and Decarbonylation Reactions of Esters

Research Project

Project/Area Number	15H03811
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Synthetic chemistry
Research Institution	Osaka University
Principal Investigator	Tobisu Mamoru 大阪大学, 工学研究科, 教授 (60403143)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000) Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords	遷移金属触媒 / 脱カルボニル化 / ニッケル錯体 / 脱炭酸 / 合成化学 / 触媒反応 / ケトン / 有機合成
Outline of Final Research Achievements	Decarbonylation of ketones is a challenging transformation becasue it requires the cleavage of carbon-carbon bonds. All reported methods for decarbonylation of simple ketones use a stoichiometric amount of rhodium catalysts. In this study, we found the first nickel system that can promote decarbonylation of simple ketones. In addition, nickel-catayzed decarboxylation of aryl carbamates, leading to the formation of arylamines was developed.

Report

(4 results)