| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) is a change in migration phenotype. It is thought as a promising target for cancer therapy. However, there was no convenient methods for the quantitative evaluation of EMT in physiologically relevant conditions. In the project, we revised our original photoactivatable substrates from the viewpoint of manipulating cellular mechanical environments and improving the responsivity of the photochemical reactions to make the platforms more suitable for the EMT assay. We have also succeeded in developing a mathematical method for the EMT quantification.
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