| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
The aim of this work was to develop new chemical biology techniques for controlling protein localization and cell signaling using synthetic self-localizing ligands (SLLs). We successfully developed new SLL-based methods that allow: (1) inducible protein translocation from the cytoplasm to the inner-leaflet of the plasma membrane, (2) orthogonal control of two distinct signaling molecules and pathways in single cells, (3) temporal control of signal duration, and (4) inducible protein translocation to the ER/Golgi membranes (endomembranes).
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