| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
Establishment of chemical methodology to control functions of molecules under biocompatible conditions is difficult while valuable tasks to be challenged. Maturation of such chemistry would have large impact on industrial as well as academic research for the construction of functional molecules aiming at medicinal applications, such as inhibition of adverse effect, development of new action mechanism, realization of drug delivery systems. In this study, we successfully constructed nucleic acid aptamers capable of exhibiting structural transition in response to biocompatible reduction stimuli on the basis of semi-rational molecular design, in which biomolecules such as nucleic acids are coupled with chemically reactive artificial molecules with a precision at molecular level.
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