| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
Phosphorothioate nucleic acids in which sulfur atoms are introduced to internucleotidic phosphodiester linkages are widely used as nucleic acid drugs in order to enhance the stability in vivo. However, they are a mixture of numerous stereoisomers based on the chiral phosphorus atoms. In this study, we selected the molecule that is most stable in vivo and high in pharmacological activity among many stereoisomers, and established the basic principle of the method for determining the absolute configuration of the phosphorus atoms. Further improvement of this method can be expected to lead to establishment of a technique for selecting a molecule that works most effectively as a drug in vivo and determining the absolute configuration of its phosphorus atoms.
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