Recognition and reduction of modern water pollutions using 3D stationary phase having cell membrane functions

• Project/Area Number: 15H03846
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Green/Environmental chemistry
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Hosoya Ken 京都府立大学, 生命環境科学研究科, 教授 (00209248)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
• Keywords: 汚染除去材料 / ＨＰＬＣ / ３Ｄ固相 / 表面修飾 / ＭＰＣ / 細胞機能 / 血液評価 / スプレー法 / HPLC / 3D固相 / MPC / ３D固相

Outline of Final Research Achievements

The purpose of this study is to construct a pseudo-cell membrane layer that captures pharmaceutical and personal care products (PPCP) from the aqueous phase, 2) Create a pseudo-hydrophilic interaction separation layer capable of fully retaining captured PPCP, 3) Recognizing the characteristics of PPCP,
A multidimensional mechanism to eliminate contaminants is to construct a molecular template layer. After three years of study, we succeeded in capturing concentration and quantification from the actual river water of sulpiride, the final purpose of this study, and completed the research purpose. This result has been confirmed to be effective for compounds such as shellfish poison, saxitoxin, and domoic acid, which have recently been a problem, not only the sulpiride used as a model, and has become a result of the developments.

Research Products

• [Journal Article] Effect of Solvents on the Surface Modification of Hydrophilic Macro-Porous Particles with an Ion-Exchange Monomer Having Both Anion and Cation Exchange Groups (2016)
  • Author(s): K. Shibata, T. Tanigawa, H. Ito, T. Kubo, and K. Hosoya,
  • Journal Title: CHROMATOGRAPHY Volume: 37 Issue: 3 Pages: 99-104
  • DOI: 10.15583/jpchrom.2016.004
  • NAID: 130005277409
  • ISSN: 1342-8284, 1348-3315
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Molecularly Imprinted Polymers for Selective Adsorption of Lysozyme and Cytochrome c Using a PEG-Based Hydrogel: Selective Recognition for Different Conformations due to pH Conditions (2015)
  • Author(s): Kubo, T.; Arimura, S.; Tominaga, Y.; Naito, T.; Hosoya, K.; Otsuka, K.
  • Journal Title: Macromolecules Volume: 48 Issue: 12 Pages: 4081-4087
  • DOI: 10.1021/acs.macromol.5b00834
  • Peer Reviewed
• [Presentation] 血球分離膜の開発 (2017)
  • Author(s): 古川真由，柴田佳那美，細矢 憲
  • Organizer: 第２８回クロマトグラフィー科学会議
• [Presentation] イオン交換基の働きで血液を分ける (2016)
  • Author(s): 柴田 佳那美，古川麻由，関豊光，細矢憲
  • Organizer: 第２７回クロマトグラフィー科学会議
  • Place of Presentation: 慶応義塾大学薬学部（東京都港区）
  • Year and Date: 2016-11-17
• [Presentation] マイクロ球状粒子のクロマトグラフィー特性基礎検討 (2016)
  • Author(s): 谷川 哲也，上本英雄，永田智浩，細矢憲
  • Organizer: 第２７回クロマトグラフィー科学会議
  • Place of Presentation: 慶応義塾大学薬学部（東京都港区）
  • Year and Date: 2016-11-17
• [Presentation] イオン交換基の働き方を制御する (2015)
  • Author(s): 柴田佳那美，関 豊光，伊東晴香，細矢 憲
  • Organizer: 第２６回クロマトグラフィー科学会議
  • Place of Presentation: 九州大学医学系キャンパスコラボステーション
  • Year and Date: 2015-11-11
• [Book] 化学の基本シリーズ２ 有機化学 (2017)
  • Author(s): 久保拓也，細矢 憲
  • Total Pages: 153
  • Publisher: 化学同人
  • ISBN: 9784759818451
• [Remarks] 最優秀発表賞の受賞について（京都府立大学HP)
  • URL: http://www.kpu.ac.jp/contents_detail.php?co=ser&frmId=5436
• [Remarks] 学会賞等の受賞
  • URL: http://www2.kpu.ac.jp/life_environ/poly_mat_design/index.html