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Construction of functional molecular arrays using DNA as a structural scaffold

Research Project

Project/Area Number 15H03884
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Device related chemistry
Research InstitutionUniversity of Hyogo

Principal Investigator

Yamana Kazushige  兵庫県立大学, 工学研究科, 教授 (70192408)

Co-Investigator(Kenkyū-buntansha) 高田 忠雄  兵庫県立大学, 工学研究科, 准教授 (60511699)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
KeywordsDNA / 光 / 電子移動 / 機能性色素分子 / デバイス / 光電変換 / バイオセンサー / エネルギー移動 / 蛍光プローブ / 発光 / ナノ構造体 / ナノ材料 / 生体材料 / 超分子化学 / 光デバイス / 機能性色素 / 自己組織化
Outline of Final Research Achievements

Molecular arrays of functional chromophores placed in a specific and precise manner were constructed exploiting DNA as a structural scaffold, potentially realizing efficient light harvesting, migration, and electron transport. We developed new methods to prepare DNA with molecular array composed of the functional chromophores using conventional DNA synthesis, post-synthetic modification using click reaction, and enzymatic reaction by uracil DNA glycosylase. Photochemical and physical properties of the chromophores in DNA were characterized using spectroscopic methods and (photo)electrochemical measurements.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Circularly polarized luminescence of helically assembled pyrene π-stacks on RNA and DNA duplexes2018

    • Author(s)
      Nakamura Mitsunobu、Ota Fuyuki、Takada Tadao、Akagi Kazuo、Yamana Kazushige
    • Journal Title

      Chirality

      Volume: 30 Issue: 5 Pages: 602-608

    • DOI

      10.1002/chir.22838

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid electron transfer of stacked heterodimer of perylenediimide derivatives in a DNA duplex2018

    • Author(s)
      Takada Tadao、Ishino Syunya、Takata Ami、Nakamura Mitsunobu、Fujitsuka Mamoru、Majima Tetsuro、Yamana Kazushige
    • Journal Title

      Chemistry - A European Journal

      Volume: 印刷中 Issue: 32 Pages: 8228-8232

    • DOI

      10.1002/chem.201800947

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Luminescent Perylenediimide as a Binding Ligand for Pyrimidine/Pyrimidine Mismatches Within a DNA Duplex2017

    • Author(s)
      Takada Tadao、Umakoshi Yu、Nakamura Mitsunobu、Yamana Kazushige
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 21 Pages: 6047-6051

    • DOI

      10.1002/slct.201701310

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photoresponsive Electrodes Modified with DNA Duplexes Possessing a Porphyrin Dimer2017

    • Author(s)
      Takada Tadao、Iwaki Toshihiro、Nakamura Mitsunobu、Yamana Kazushige
    • Journal Title

      Chemistry - A European Journal

      Volume: 23 Issue: 72 Pages: 18258-18263

    • DOI

      10.1002/chem.201704281

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA-templated synthesis of perylenediimide stacks utilizing abasic sites as binding pockets and reactive sites2016

    • Author(s)
      T. Takada, M. Ido, A. Ashida, M. Nakamura, K. Yamana
    • Journal Title

      ChemBioChem

      Volume: 17 Issue: 23 Pages: 2230-2233

    • DOI

      10.1002/cbic.201600454

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Blockade and staircase phenomena of holes in mesoscopic scale λ-deoxyribonucleic acid/SiO2/Si structure2016

    • Author(s)
      N. Matsuo, T. Takada, A. Heya, K. Yamana, T. Sato, S. Yokoyama, Y. Omura
    • Journal Title

      IEEE Electron Device Letters

      Volume: 37 Issue: 2 Pages: 224-227

    • DOI

      10.1109/led.2015.2510451

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helically Assembled Pyrene Arrays on an RNA Duplex that Exhibit Circularly Polarized Luminescence with Excimer Formation2016

    • Author(s)
      M. Nakamura, J. Suzuki, F. Ota, T. Takada, K. Akagi, K. Yamana
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 27 Pages: 9121-9124

    • DOI

      10.1002/chem.201602043

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Donor-acceptor heterojunction configurations based on DNA-multichromophore arrays2015

    • Author(s)
      M. Nakamura, K. Tsuto, A. Jomura, T. Takada, K. Yamana
    • Journal Title

      Chem. Eur. J

      Volume: 21 Issue: 33 Pages: 11788-11792

    • DOI

      10.1002/chem.201501955

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] "Signal-On"型電気化学核酸プローブを利用した標的核酸検出センサーの開発2018

    • Author(s)
      西村 弘基・高田 忠雄・山下 智也・中村 光伸・山名 一成
    • Organizer
      日本化学会 第98春季年会 (2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] シアニン色素を構造内部に有する発光性核酸プローブの開発2018

    • Author(s)
      西田 航磨・高田 忠雄・本多 由理佳・中野 葵・中村 光伸・山名 一成
    • Organizer
      日本化学会 第98春季年会 (2018)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ピラー型電極を利用した高感度電気化学DNAセンサーの開発2017

    • Author(s)
      山下 智也・高田 忠雄・中村 光伸・山名 一成
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] DNA構造を利用したチアゾール会合体の構築と発光特性制御2017

    • Author(s)
      本多 由理佳・高田 忠雄・中村 光伸・山名 一成
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県横浜市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Artificial Nucleic Acid Probes Possessing Stacked Fluorescent Chromophores2017

    • Author(s)
      Tadao, Takada, Aoi Nakano, Mitsunobu Nakamura, Kazushige Yamana
    • Organizer
      ISNAC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 発光性色素クラスターを有するDNAの作製と発光特性評価2016

    • Author(s)
      高田 忠雄・本多 由理佳・中村 光伸・山名 一成
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京大学駒場第一キャンパス(東京都目黒区)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ピレン修飾核酸の蛍光挙動2016

    • Author(s)
      鈴木 淳平・中村 光伸・高田 忠雄・ 山名 一成
    • Organizer
      2016年光化学討論会
    • Place of Presentation
      東京大学駒場第一キャンパス(東京都目黒区)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Fluorescent nucleic acids possessing perylenediimide stacks2016

    • Author(s)
      Tadao Takada, Kazushige Yamana
    • Organizer
      2016 International Round Table on Nucleosides, Nucleotides and Nucleic Acids
    • Place of Presentation
      パリ(フランス)
    • Year and Date
      2016-07-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DNAを鋳型にした色素会合体の構築とその連結の検討2016

    • Author(s)
      鈴木淳平, 中村光伸, 高田忠雄, 山名一成
    • Organizer
      日本化学会 第96春季年会
    • Place of Presentation
      同志社大学(京都府京田辺市)
    • Year and Date
      2016-03-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Photochemical characterization of homo- and heterocomplexes of perylenediimide derivatives constructed within DNA duplex2015

    • Author(s)
      Tadao Takada, Syunya Ishino, Misa Ido, Mitsunobu Nakamura, Kazushige Yamana
    • Organizer
      ISNAC 2015
    • Place of Presentation
      イーグレ姫路(兵庫県姫路市)
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Construction of DNA-modified electrodes with gold nanoparticles showing photocurrent response2015

    • Author(s)
      Syunori Kazue, Tadao Takada, Mitsunobu Nakamura, Kazushige Yamana
    • Organizer
      ISNAC 2015
    • Place of Presentation
      イーグレ姫路(兵庫県姫路市)
    • Year and Date
      2015-09-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ペリレンジイミドヘテロダイマーを有する核酸コンジュゲートの作製と核酸検出蛍光センサーへの応用2015

    • Author(s)
      高田忠雄, 石野竣也, 中村光伸, 山名一成
    • Organizer
      第9回バイオ関連化学シンポジウム
    • Place of Presentation
      熊本大学(熊本県熊本市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ペリレンジイミドのヘテロ二量体を有するDNA複合体の発光応答と蛍光バイオセンサーへの応用2015

    • Author(s)
      高田忠雄, 石野竣也, 井戸美佐, 中村光伸, 山名一成
    • Organizer
      2015年光化学討論会
    • Place of Presentation
      大阪市立大学(大阪府大阪市)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
  • [Book] Modified Nucleic Acids2016

    • Author(s)
      Tadao Takada, Mitsunobu Nakamura, Kazushige Yamana
    • Total Pages
      20
    • Publisher
      Springer Link
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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