| Budget Amount *help |
¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
In this study, we aimed to give the mechano-compatibility to the scaffold for regenerated bone made of calcined bovine cancellous bone. The following results were obtained. Calcined bovine cancellous bone was nanoparticulated and mixed with alginic acid. The composite has mechanical properties close to those of a living compact bone. Furthermore, silanol crosslinking of the alginic acid made the composite mechanically-stable in simulated body fluid. In addition, Micro-CT imaging technique confirmed that the combination of random pulse electromagnetic field stimulation and surface modification with RGDS peptide promotes bone matrix production and calcification by osteoblasts in the scaffold.
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