Rheology in network microchannel based on biomechanics of blood cells and its application to acute circulatory failure
| Project/Area Number |
15H03915
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fluid engineering
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
LIU Hiroshi
SUGAWARA Michiko
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | バイオメカニクス / 血流 / 微小循環 / 血球 / 細胞 / 赤血球 / ネットワーク流路 / 白血球 |
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| Outline of Final Research Achievements |
Using in vitro and computer modeling from biomechanical viewpoints, we investigated the blood flow mechanism in network microchannel that ranges from single blood cell’s motion and deformation, motions of an assemblage of blood cells, and up to blood flow in entire network channel. We clarified that mechanical properties of a red blood cell from membrane’s viscoelasticity play an important role in motion and deformation in shear flow. We also demonstrated that in a network microchannel, a blood flow at bifurcation was determined by interaction between flow rate distribution at the bifurcation and flows in the surrounding channels. These points are considered important in acute failure of microcirculation.
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| Academic Significance and Societal Importance of the Research Achievements |
微小循環の血流において，赤血球の力学特性や血管網の幾何学的構造は重要な役割を果たすと考えられてきたが，どのように重要かは不明であった．この点の一端を，本研究では明らかにすることが出来た点で，微小循環の理解をバイオメカニクスの観点から一歩進めることが出来た成果といえる．このことは，急性を含む病的な微小循環の変化の総合的な理解にも役立つと考えられる．このように，循環挙動を深く理解していくことで，最終的には，循環挙動の予測が可能になり，急性循環障害の簡便かつ高度な診断方法の開発にも繋がる．
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Dynamics of Actin Stress Fibers and Focal Adhesions during Slow Migration in Swiss 3T3 Fibroblasts: Intracellular Mechanism of Cell Turning2016
Author(s)
Sugawara, M., Miyoshi, H., Miura, T., Tanaka, H., Tsubota, K. and Liu, H.
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Journal Title
BioMed Research International
Volume: 12
Pages: 5749749-5749749
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cavopulmonary Connection Is Superior to Atriopulmonary ConnectionFontan in Preventing Thrombus Formation: Computer Simulation of Flow-Related Blood Coagulation2015
Author(s)
Sughimoto, K., Okauchi, K., Zannino, D., Brizard, C., Liang, F.,Sugawara, M., Liu, H. and Tsubota, K.
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Journal Title
Pediatric Cardiology
Volume: 36
Issue: 7
Pages: 1436-1441
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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