• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of propagating micro-shock wave induced by ultra-short time pulse laser and its application to microcapsule for regenerative medicine

Research Project

Project/Area Number 15H03921
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fluid engineering
Research InstitutionKyushu Institute of Technology

Principal Investigator

Tamagawa Masaaki  九州工業大学, 大学院生命体工学研究科, 教授 (80227264)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords衝撃波 / 超短レーザー / 水中衝撃波 / マイクロカプセル / フェムト秒レーザ / 細胞刺激 / 最大圧力 / 医療工学 / 気泡
Outline of Final Research Achievements

In this research project, we obtained pressure waves by focusing femto-seconds pulse laser with establishment of optical system. The maximum pressure at optical focal point was obtained, and it was estimated to be 0.2-0.3 MPa by averaging every maximum pressure with shot number, as the signal noise ratio (S/N ratio) of each shot by pressure sensor was not good. This value is considered to be enough for stimulating cells, but small for disintegration of cells. From this result, it was suggested that these shock waves induced by short time pulse laser can be applied to regenerative system. In addition to this, it was found that micro bubbles can be generated with plasma luminescence. This finding should be investigated in future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Analysis of Deformation Process of a Bubble in an Elastic Capsule by Shock Waves and Their Medical and Biological Applications,2018

    • Author(s)
      M. Tamagawa, T. Imakado and R. Ogasahara
    • Journal Title

      Proc. of 31th International Symposium on Shock Waves

      Volume: 2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of Deformation Process of a Bubble in a Capsule by Pressure Wave for Developing Drug Delivery Systems2016

    • Author(s)
      Masaaki Tamagawa, Manami Oyama and Ryo Ogasahara
    • Journal Title

      ICIC Express Letters, Part B: Applications (An International Journal of Research and Surveys)

      Volume: Vol.7, No.9 Pages: 2039-2044

    • NAID

      40021056344

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 衝撃波組織再生培養システム開発のための時短パルスレーザー誘起衝撃波生成の検 (第2報気液ならびに固液界面位置の水中内レーザ集束に及ぼす影響)2018

    • Author(s)
      今門利和, 玉川雅章, 寺島涼介
    • Organizer
      平成29年度衝撃波シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 衝撃波培養組織再生システム開発のための時短パルスレーザー誘起衝撃波生成の検討2017

    • Author(s)
      今門利和,玉川雅章,小笠原 僚
    • Organizer
      平成28年度衝撃波シンポジウム
    • Place of Presentation
      ヴェルク横須賀(神奈川県横須賀市)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 衝撃波組織再生培養システム開発のための時短パルスレーザー誘起衝撃波生成について2017

    • Author(s)
      今門 利和, 玉川 雅章
    • Organizer
      日本機械学会 2017年度年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of Deformation Process of a Bubble in an Elastic Capsule by Shock Waves and Their Medical and Biological Applications,2017

    • Author(s)
      M. Tamagawa, T. Imakado and R. Ogasahara
    • Organizer
      31th International Symposium on Shock Waves (ISSW31)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 衝撃波を利用した培養組織再生システムの開発のための 気泡内包マイクロカプセルの設計について2016

    • Author(s)
      小笠原 僚,玉川 雅章,江副 佑樹
    • Organizer
      日本機械学会2016年度年次大会
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2016-09-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of Deformation Process of a Bubble in a Capsule by Pressure Wave for Developing Drug Delivery Systems2016

    • Author(s)
      Masaaki Tamagawa, Manami Oyama and Ryo Ogasahara
    • Organizer
      ICICIC2016
    • Place of Presentation
      Harbin Institute of Technology (Harbin, China)
    • Year and Date
      2016-08-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 衝撃波を利用した3D細胞培養用カプセル開発のための内部気泡変形挙動解析と破壊2016

    • Author(s)
      小笠原僚, 玉川雅章, 江副祐樹
    • Organizer
      平成27年度衝撃波シンポジウム
    • Place of Presentation
      東海大学(熊本県熊本市)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 衝撃波による再生用マイクロカプセル開発のためのカプセル破壊と内部気泡挙動解析2016

    • Author(s)
      小笠原僚,玉川雅章,江副佑樹, 山畳悠司
    • Organizer
      日本機械学会バイオエンジニアリング部門講演会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2016-01-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 各種環境下における衝撃波刺激による好中球走化性への影響2015

    • Author(s)
      玉川雅章,廣瀬智也
    • Organizer
      第28回バイオメディカル・ファジィ・システム学会年次大会(BMFSA2015)
    • Place of Presentation
      東海大学(熊本県熊本市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 衝撃波を利用した培養組織再生システムの開発のためのカプセル内気包変形挙動解析2015

    • Author(s)
      江副佑樹, 玉川雅章, 小山真奈未
    • Organizer
      日本機械学会 2015年度年次大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] DDS用気泡内包マイクロカプセルの圧力波による破壊制御の解析2015

    • Author(s)
      玉川雅章
    • Organizer
      第54回日本生体医工学会大会 (シンポジウム・ワークショップ・パネル)
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Book] 高度物理刺激と生体応答(“衝撃波による細胞刺激” 分担)2017

    • Author(s)
      玉川雅章
    • Total Pages
      198
    • Publisher
      養賢堂
    • ISBN
      9784842505626
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi