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Nanoparticle Imaging with Vectorial Polarization Interferometric Laser Microscope

Research Project

Project/Area Number 15H03945
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionShizuoka University

Principal Investigator

Egami Chikara  静岡大学, 工学部, 教授 (70262798)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywordsレーザー顕微鏡 / 微粒子 / 偏光干渉 / レーザ顕微鏡 / 計測工学 / 顕微鏡 / 非線形光学
Outline of Final Research Achievements

In recent years, applications of nano-particles to medical diagnosis and medical treatment have been studied intensively. Increasing attention to nanoparticle in particular has been devoted to drug delivery system (DDS). There are varieties of DDS technologies and a very significant number of DDS medicines already launched out in the world.
In this paper, incorporating a polarization interferometer into a nonlinear confocal microscope, we propose polarization-interferometric nonlinear confocal microscopy in order to analyze a single nanoparticle (200-nm diameter) doped with organic chromophores in liquid solutions. Measuring nanoparticles less than a half wavelength of an illuminating wave, general optical microscopes have poor spatial resolving power without toxic fluorescent indicator probes. We studied the contrast transfer function (CTF) and three dimensional spectroscopic imaging of the nanoparticle.

Academic Significance and Societal Importance of the Research Achievements

現在のDDSはAFM表面計測が主流であり,より複雑な内部立体構造を有する球形デンドリマ等では計測が不可能で,より簡便で有効な構造解析手段が未だ提案されていないのが実情であり、各国がしのぎを削っている.当方が考案した偏光干渉顕微技術はこれをブレークスルーできる可能性があり,DDS輸送体の分光イメージングへ応用展開も可能であると判断し研究をスタートした.結果,提案技術はDDS輸送体の3次元分光計測において非常に有効な手法であり,医学・バイオの研究領域における波及効果が大きいということが確かめられた.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (10 results) (of which Int'l Joint Research: 10 results)

  • [Journal Article] Spectroscopic Imaging of DDS Nano-particle by Polarization Interferometric Nonlinear Confocal Microscopy2018

    • Author(s)
      Chikara Egami and Shota Kawasaki
    • Journal Title

      Proc. FiO 2018

      Volume: JTu3A Pages: 105-106

    • Related Report
      2018 Annual Research Report
  • [Journal Article] High-contrast-resolution single nano-particle imaging with MEMS-scanning mirrors based polarization-interferometric nonlinear optical microscope2018

    • Author(s)
      Chikara Egami and Shota Kawasaki
    • Journal Title

      Proc. ANNIC 2018

      Volume: PS11

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Optical anisotropy measurement of polymeric nanoparticle with polarization interferometric confocal microscope2017

    • Author(s)
      Yuki Hata and Chikara Egami
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 654 Pages: 169-173

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High contrast measurement of nanoparticle with polarization interferometric nonlinear confocal microscope2016

    • Author(s)
      Kohei Fujita and Chikara Egami
    • Journal Title

      Mol. Cryst. Liq. Cryst.

      Volume: 629 Pages: 254-257

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of inhomogeneous absorptive organic media with polarization interferometric confocal microscope2015

    • Author(s)
      Kohei Fujita and Chikara Egami
    • Journal Title

      Opt. Rev.

      Volume: 22 Pages: 410-414

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 3D Measurement of Polymeric Microspheres using Degenerate Four-Wave Mixing Confocal Microscopy2018

    • Author(s)
      Naoya Matsunaga and Chikara Egami
    • Organizer
      KJF-ICOMEP 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Three-dimensional Submicron Structures using Nonlinear Reaction-time-constant Manipulation of Photoresist2018

    • Author(s)
      Daigo Ikke and Chikara Egami
    • Organizer
      KJF-ICOMEP 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tomographic Imaging of DDS Polymeric Nanoparticle with Polarization Interferometric Confocal Microscope2018

    • Author(s)
      Shota Kawasaki
    • Organizer
      KJF-ICOMEP 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional imaging of DDS particle with polarization interferometric confocal microscope including MEMS mirror scanner2017

    • Author(s)
      Shota Kawasaki and Chikara Egami
    • Organizer
      KJF-ICOMEP 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-contrast-resolution single nanoparticle spectroscopy with MEMS-scanning mirrors based polarization-interferometric laser microscope2017

    • Author(s)
      Chikara Egami and Yuki Hata
    • Organizer
      ANNIC2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microanalysis of DDS Nanoparticle by Polarization Interferometric Nonlinear Confocal Microscopy2016

    • Author(s)
      Chikara Egami
    • Organizer
      ANNIC2016
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optical Anisotropy Measurement of Polymeric Nanoparticle with Polarization Interferometric Confocal Microscope2016

    • Author(s)
      Yuki Hata and Chikara Egami
    • Organizer
      KJF2016
    • Place of Presentation
      ACROS Fukuoka, Hakata, Fukuoka
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spectroscopy of DDS Polymeric Nanoparticle with Polarization Interferometric Nonlinear Confocal Microscopy2016

    • Author(s)
      Chikara Egami and Ryo Suzuki
    • Organizer
      Advanced Photonics 2016
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2016-07-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Microanalysis of Nanoparticle with Polarization Interferometric Nonlinear Confocal Microscope2015

    • Author(s)
      Chikara Egami
    • Organizer
      ANNIC2015
    • Place of Presentation
      Paris, France
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optical Anisotropy Measurements in Submicron Range with Polarization Interferometric Nonlinear Confocal Microscope2015

    • Author(s)
      Ryo Suzuki and Chikara Egami
    • Organizer
      KJF2015
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2015-09-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-03-30  

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