| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
In recent years, applications of nano-particles to medical diagnosis and medical treatment have been studied intensively. Increasing attention to nanoparticle in particular has been devoted to drug delivery system (DDS). There are varieties of DDS technologies and a very significant number of DDS medicines already launched out in the world.
In this paper, incorporating a polarization interferometer into a nonlinear confocal microscope, we propose polarization-interferometric nonlinear confocal microscopy in order to analyze a single nanoparticle (200-nm diameter) doped with organic chromophores in liquid solutions. Measuring nanoparticles less than a half wavelength of an illuminating wave, general optical microscopes have poor spatial resolving power without toxic fluorescent indicator probes. We studied the contrast transfer function (CTF) and three dimensional spectroscopic imaging of the nanoparticle.
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