• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of Motion Generation Mechanism in Caenorhabditis elegans based on Neuro-Muscle-Body Dynamics Model

Research Project

Project/Area Number 15H03950
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionHiroshima University

Principal Investigator

Toshio Tsuji  広島大学, 工学研究科, 教授 (90179995)

Co-Investigator(Kenkyū-buntansha) 鈴木 芳代  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10507437)
曽 智  広島大学, 工学研究科, 助教 (80724351)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsバイオメカニクス / C. elengans / 放射線影響 / 這行運動 / 数理モデル化 / C. elegans / 這行行動
Outline of Final Research Achievements

Aiming to elucidate the motion generation mechanism and the radiation effects on the motion of Caenorhabditis elegans (C. elegans), we developed a neuro-muscle-body dynamics model as a C. elegans simulator. First, we constructed a body dynamics model based on the mechanical characteristics of the actual animal, and a neuro-muscle model that preserves the actual connectome. We then quantified the motion of C. elegans by video-analysis and proposed a machine learning algorithm to adjust the model parameters representing the strengths of synapse and gap connections using the quantified motions as the teacher signals. The simulations on chemotaxis and muscle activity generation are performed using the developed C. elegans simulator. In addition, we developed a three-dimensional graphics model of C. elegans to visualize the estimated neural responses and the connection structure of the neural circuits.

Academic Significance and Societal Importance of the Research Achievements

放射線影響を解析するにあたって,線虫の動きを抑制して中枢神経などを狙って放射線を照射する必要があったため,高い保水性能を備えた線虫保定用PDMSマイクロチップを開発した.本マイクロチップは線虫以外の生物実験にも応用可能であり,2件の特許を申請している.また,実接続構造を保存した神経回路モデルを用い,化学走性に関与する介在ニューロンの情報処理に計算論的解釈を与えるとともに,運動リズムの生成には中枢神経の関与は限定的で運動ニューロンが重要な役割を果たすことを示唆した.これらはボトムアップ的手法とトップダウン的手法の相互補完によって初めて達せられた成果であり,この点に本研究の学術的意義がある.

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] A computational model of internal representations of chemical gradients in environments for chemotaxis of Caenorhabditis elegans2018

    • Author(s)
      Soh Zu、Sakamoto Kazuma、Suzuki Michiyo、Iino Yuichi、Tsuji Toshio
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17190-17190

    • DOI

      10.1038/s41598-018-35157-1

    • NAID

      120006800826

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Estimation Method for Environmental Friction Based on Body Dynamic Model of ligCaenorhabditis elegansl/ig2017

    • Author(s)
      Soh Zu、Suzuki Michiyo、Tsuji Toshio
    • Journal Title

      Journal of Robotics, Networking and Artificial Life

      Volume: 4 Issue: 1 Pages: 32-40

    • DOI

      10.2991/jrnal.2017.4.1.8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Quantitative analysis of effects on muscular movements by oxygen exposure and ionizing radiation in Caenorhabditis elegans2017

    • Author(s)
      Michiyo Suzuki, Sumino Yanase, Nobuko Murakami, Tomoo Funayama
    • Organizer
      The 7th International Society of Radiation Neurobiology Conference
    • Place of Presentation
      Yuzawa-machi, Niigata, Japan
    • Year and Date
      2017-02-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Estimation Method for Environmental Friction Based on Body Dynamic Model of Caenorhabditis elegans2017

    • Author(s)
      Zu Soh, Michiyo Suzuki and Toshio Tsuji
    • Organizer
      the 2017 International Conference on Artificial Life and Robotics (ICAROB2017)
    • Place of Presentation
      Segaia Convention Center, Miyazaki, Japan
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 宇宙放射線による線虫の運動機能への影響に迫る2016

    • Author(s)
      鈴木 芳代,服部 佑哉,坂下 哲哉,舟山 知夫,横田 裕一郎,小林 泰彦
    • Organizer
      放射線影響学会第59回大会
    • Place of Presentation
      広島市
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 放射線応答解析に向けた線虫の数理モデル構築の試み2016

    • Author(s)
      曽 智,坂本 一馬,鈴木 芳代,辻 敏夫
    • Organizer
      放射線影響学会第59回大会
    • Place of Presentation
      広島市
    • Year and Date
      2016-10-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of a method for the region-specific microbeam irradiation of C. elegans and analysis of the effects regarding locomotion2016

    • Author(s)
      Michiyo Suzuki, Yuichiro Yokota, Tomoo Funayama
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      Nagoya University, Nagoya, Japan
    • Year and Date
      2016-07-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 放射線に強い動物にあえて注目する理由 ~線虫の運動機能に対する放射線の影響とその回復~2016

    • Author(s)
      鈴木 芳代,小林 泰彦
    • Organizer
      第53回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京大学
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] A neural network model of Caenorhabditis Elegans and simulation of Chemotaxis-related Information Processing2015

    • Author(s)
      Kazuma Sakamoto, Zu Soh, Michiyo Suzuki, Yuichi Kurita and Toshio Tsuji
    • Organizer
      SAI Intelligent Systems Conference 2015
    • Place of Presentation
      London
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computer Simulation of Chemotaxis in Caenorhabditis Elegans in Consideration of Whole-body Movements2015

    • Author(s)
      Zu Soh, Michiyo Suzuki, Yuichi Kurita and Toshio Tsuji
    • Organizer
      SAI Intelligent Systems Conference 2015
    • Place of Presentation
      London
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 生体システム論研究室ホームページ

    • URL

      http://www.bsys.hiroshima-u.ac.jp/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 広島大学生体システム論研究室

    • URL

      http://www.bsys.hiroshima-u.ac.jp/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi