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Position-controlled graphene with high quality and glycan-functionalized graphene devices for influenza virus

Research Project

Project/Area Number 15H03986
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Electron device/Electronic equipment
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Maehashi Kenzo  東京農工大学, 工学(系)研究科(研究院), 教授 (40229323)

Co-Investigator(Kenkyū-buntansha) 大野 恭秀  徳島大学, 大学院社会産業理工学研究部(理工学域), 准教授 (90362623)
金井 康  大阪大学, 産業科学研究所, 助教 (30721310)
生田 昂  東京農工大学, 工学(系)研究科(研究院), 助教 (80805929)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsグラフェン / インフルエンザウイルス / 糖鎖 / 核形成位置制御法 / マイクロ・ナノデバイス / ナノ材料
Outline of Final Research Achievements

There are global concerns about threat of pandemic caused by the human-infectious avian influenza virus. Graphene devices realize such high-sensitive electrical detection of the targets, owing to graphene’s high carrier mobility. In this study, we have succeeded in growing position-controlled graphene which has high carrier mobility by tuning the nucleation density on catalytic copper surface. Moreover, graphene was functionalized using sialoglycans and employed for the selective detection of lectins from Sambucus sieboldiana and Maackia amurensis as alternatives of the human and avian influenza viruses. Glycan-functionalized graphene devices selectively monitored the sialoglycan-specific binding reactions at subnanomolar sensitivity.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results)

  • [Journal Article] Lab-on-a-Graphene: Functionalized Graphene Transistors and Their Application for Biosensing2017

    • Author(s)
      Ono Takao、Kanai Yasushi、Ohno Yasuhide、Maehashi Kenzo、Inoue Koichi、Matsumoto Kazuhiko
    • Journal Title

      Carbon-related Materials in Recognition of Nobel Lectures

      Volume: なし Pages: 79-90

    • DOI

      10.1007/978-3-319-61651-3_4

    • ISBN
      9783319616506, 9783319616513
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glycan-functionalized graphene-FETs toward selective detection of human-infectious avian influenza virus2017

    • Author(s)
      Takao Ono
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 3 Pages: 030302-030302

    • DOI

      10.7567/jjap.56.030302

    • NAID

      210000147449

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamical thermodiffusion model of graphene synthesis on polymer films by laser irradiation and application to strain sensors2017

    • Author(s)
      Kanai Yasushi、Ishibashi Yusuke、Ono Takao、Inoue Koichi、Ohno Yasuhide、Maehashi Kenzo、Matsumoto Kazuhiko
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7 Pages: 075102-075102

    • DOI

      10.7567/jjap.56.075102

    • NAID

      210000148001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utilizing research into electrical double layers as a basis for the development of label-free biosensors based on nanomaterial transistors2016

    • Author(s)
      K. Maehashi, Y. Ohno, K. Matsumoto
    • Journal Title

      Nanobiosensors in Disease Diagnosis

      Volume: 5 Pages: 1-13

    • DOI

      10.2147/ndd.s40316

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graphene device array using transfer-free patterned growth on insulator for an electrolyte-gated sensor2016

    • Author(s)
      Takashi Ikuta
    • Journal Title

      Thin Solid Films

      Volume: 612 Pages: 87-90

    • DOI

      10.1016/j.tsf.2016.05.040

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] グラフェンFET上でのインフルエンザウイルス/抗体結合のウレアーゼ反応による検出2018

    • Author(s)
      山本 佳織、小野 尭生、牛場 翔太、金井 康、谷奥 正巳、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、中北 愼一、河原 敏男、鈴木 康夫、木村 雅彦、松本 和彦
    • Organizer
      第65回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザウイルスのヒト感染性と亜型の鑑別2018

    • Author(s)
      山中 天志、白井 充、小野 尭生、牛場 翔太、金井 康、谷奥 正巳、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、中北 愼一、河原 敏男、鈴木 康夫、木村 雅彦、松本 和彦
    • Organizer
      第65回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reaction of Viral Proteins and Sialoglycan on Biomimetic Graphene Surface Measured by Liquid Atomic Force Microscope and Graphene Field-Effect Transistor2017

    • Author(s)
      Kaho Kamada, Takao Ono, Ryota Hayashi, Yasushi Kanai, Koichi Inoue, Yasuhide Ohno, Kenzo Maehashi, Yohei Watanabe, Shin-ichi Nakakita, Yasuo Suzuki, Toshio Kawahara, Sonia. A. Contera and Kazuhiko Matsumoto
    • Organizer
      59th Electronic Materials Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of Enzymatic Reaction Using Graphene Field-Effect Transistor and Microwell for Detection of Helicobacter Pylori2017

    • Author(s)
      Takao Ono, Yasushi Kanai, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue and Kazuhiko Matsumoto
    • Organizer
      59th Electronic Materials Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical Sensing using Graphene-based Surface-Acoustic-Wave Sensor2017

    • Author(s)
      Satoshi Okuda, Takao Ono, Yasushi Kanai, Masaaki Shimatani, Shinpei Ogawa, Takashi Ikuta, Koichi Inoue, Kenzo Maehashi, and Kazuhiko Matsumoto
    • Organizer
      2017 Int. Conf. Solid State Devices and Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞表面環境を模したグラフェンFETによるインフルエンザウイルス検出2017

    • Author(s)
      川田拓哉、小野尭生、金井康、大野恭秀、前橋兼三、井上恒一、渡邊洋平、河原敏男、鈴木康夫、中北愼一、松本和彦
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザバイオセンサー開発のための糖鎖分子の比較2017

    • Author(s)
      河原敏男、平松宏明、大海雄介、鈴木康夫、林京子、中北愼一、渡邊洋平、大野恭秀、前橋兼三、小野尭生、金井康、松本和彦
    • Organizer
      第77回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エッチングフリーな単結晶グラフェンデバイスアレイの作製2016

    • Author(s)
      森 祐樹、生田 昂、金井 康、小野 尭生、大野 恭秀、前橋 兼三、井上 恒一、松本 和彦
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Position-Controlled graphene Synthesis and Development of Biological Sensors and Molecular Devices2016

    • Author(s)
      Kenzo Maehashi
    • Organizer
      The 11th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Electrical detection of biomolecules using graphene-based devices2016

    • Author(s)
      Kenzo Maehashi
    • Organizer
      PRiME
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Developments of the nano-carbon bio sensors using glycan for influenza virus2016

    • Author(s)
      Toshio Kawahara, Hiroaki Hiramatsu, Yasuo Suzuki, Shinichi Nakakita, Yasuhide Ohno, Kenzo Maehashi, Kazuhiko Matsumoto, Kazumasa Okamoto, Teruaki Matsuba, and Risa Utsunomiya
    • Organizer
      13th International Conference on Atomically Controlled Surfaces, Interfaces and Nanostructures
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Application of Graphene Field Effect Transistor to Enzymatic Assay2016

    • Author(s)
      Takao Ono, Yasushi Kanai, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue, and Kazuhiko Matsumoto
    • Organizer
      The 43rd International Symposium on Compound Semiconductor
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] インフルエンザバイオセンサー開発のための糖鎖分子の検討2016

    • Author(s)
      河原 敏男、平松 宏明、鈴木 康夫、中北 愼一、渡邊 洋平、大野 恭秀、前橋 兼三、小野 尭生、金井 康、松本 和彦
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポルフィリンリンカーを用いたグラフェンバイオセンサーの高感度化2016

    • Author(s)
      川田 拓哉、小野 尭生、金井 康、大野 恭秀、前橋 兼三、井上 恒一、松本 和彦
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖鎖機能化グラフェンFETを用いた抗ウイルス薬効評価のためのノイラミニダーゼ反応計測2016

    • Author(s)
      鎌田 果歩、小野 尭生、金井 康、大野 恭秀、前橋 兼三、井上 恒一、渡邊 洋平、河原 敏男、鈴木 康夫、中北 愼一、松本 和彦
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Position-Controlled Graphene Growth Using Micropatterning on Catalytic Copper Surface2015

    • Author(s)
      Yuki Mori, Takashi Ikuta, Takao Ono, Yasushi Kanai, Yasuhide Ohno, Kenzo Maehashi, Koichi Inoue and Kazuhiko Matsumoto
    • Organizer
      28th Int. Microprocesses and Nanotechnology Conference
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 銅触媒表面のマイクロパターニングによるグラフェンの位置制御成長2015

    • Author(s)
      森祐樹、生田昂、小野尭生、金井康、大野恭秀、前橋兼三、井上恒一、松本和彦
    • Organizer
      第76回応用物理学会春季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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