• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of the noble biodegradable implant composed of multi-phase intermetallic compounds, which spontaneously makes porous structure in human body

Research Project

Project/Area Number 15H04146
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Hagihara Koji  大阪大学, 工学研究科, 准教授 (10346182)

Co-Investigator(Renkei-kenkyūsha) NAKANO TAKAYOSHI  大阪大学, 大学院工学研究科, 准教授 (30243182)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords生体内溶解性材料 / 金属間化合物 / 生体材料 / マグネシウム合金 / 溶解挙動 / 生体親和性 / 結晶方位依存性 / カルシウム合金 / 溶解性金属材料 / インプラント / 溶解性 / 結晶方位異方性 / 複相材料 / Mg合金 / Ca合金
Outline of Final Research Achievements

In this study, we devoted the developing a novel "biodegradable implant material" which is composed of two types of intermetallic compounds having different biodegradability in a Ca-Mg-Zn ternary system. As a result of investigating in various alloy compositions, we discovered a Ca2Mg5Zn13 (IM 3) - Ca3 MgxZn(15 - x) (IM 1) dual-phase alloy, as an alloy having an island microstructure. By the various examinations in this alloy system, it was clarified that the control of the degradation behavior of the multiphase alloys can be achieved by the simultaneous control of the "characteristics of each component phase" and the "morphology of the microstructure". Furthermore, the basic experiments using a single crystal unveiled that the control of crystal orientation of constituent phases also must be an effective way for controlling the dissolution behavior of the multiphase alloys in addition to the above factors.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (20 results)

All 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Invited: 1 results)

  • [Journal Article] Experimental clarification of the cyclic deformation mechanisms of β-type Ti&;Nb;Ta;Zr-alloy single crystals developed for the single-crystalline implant2017

    • Author(s)
      K. Hagihara, T. Nakano
    • Journal Title

      International Journal of Plasticity

      Volume: 98 Pages: 27-44

    • DOI

      10.1016/j.ijplas.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unusual dynamic precipitation softening induced by dislocation glide in biomedical beta-titanium alloys2017

    • Author(s)
      Hagihara Koji、Nakano Takayoshi、Todai Mitsuharu
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-017-08211-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of magnesium alloys as a “highly-functional structural material”2017

    • Author(s)
      萩原 幸司
    • Journal Title

      Journal of Japan Institute of Light Metals

      Volume: 67 Issue: 7 Pages: 293-300

    • DOI

      10.2464/jilm.67.293

    • NAID

      130006187045

    • ISSN
      0451-5994, 1880-8018
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Texture control of beta-type Ti-15Zr-5Mo-3Al alloy by selective laser melting for the development of novel implants with an extremely low Young’s modulus2017

    • Author(s)
      T. Ishimoto, K. Hagihara, K. Hisamoto, S.-H.Sun, T. Nakano
    • Journal Title

      Scripta Materialia

      Volume: 132 Pages: 34-38

    • DOI

      10.1016/j.scriptamat.2016.12.038

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development ofsingle crystalline β-Ti implants2016

    • Author(s)
      K.Hagihara, T. Nakano, H. Maki, Y.i Umakoshi, M. Niinomi
    • Journal Title

      Scientific Reports

      Volume: 29779 Issue: 1 Pages: 1-10

    • DOI

      10.1038/srep29779

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Crystal-orientation-dependent corrosion behaviour of single crystals of a pure Mg and Mg-Al and Mg-Cu solid solutions2016

    • Author(s)
      K. Hagihara, M. Okubo, M. Yamasaki, T. Nakano
    • Journal Title

      Corrosion Science

      Volume: 109 Pages: 68-85

    • DOI

      10.1016/j.corsci.2016.03.019

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elastic-modulus enhancement during room-temperature aging and its suppression in metastable Ti-Nb-based alloys with low body-centered cubic phase stability2015

    • Author(s)
      M. Tane, K. Hagihara, M. Ueda, T. Nakano, Y. Okuda
    • Journal Title

      Acta Materialia

      Volume: 102 Pages: 373-384

    • DOI

      10.1016/j.actamat.2015.09.030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Single Crystalline Bone Plate with Low Young’s Modulus Using Beta-type Ti-15Mo-5Zr-3Al Alloy2015

    • Author(s)
      當代光陽,萩原幸司,石本卓也,山本憲吾,中野貴由
    • Journal Title

      Tetsu-to-Hagane

      Volume: 101 Issue: 9 Pages: 501-505

    • DOI

      10.2355/tetsutohagane.TETSU-2015-044

    • NAID

      130005094601

    • ISSN
      0021-1575, 1883-2954
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mg合金を中心とした,新規高機能性生体インプラント材料創成の試み2017

    • Author(s)
      萩原幸司
    • Organizer
      第66回高性能Mg合金創成加工研究会
    • Place of Presentation
      熊本大学 黒髪キャンパス
    • Year and Date
      2017-03-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Mg単結晶溶解挙動の結晶方位依存性に影響を及ぼす諸因子2017

    • Author(s)
      古田智,萩原幸司,大久保政欣,中野貴由,山崎倫昭
    • Organizer
      日本金属学会2017秋期講演大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mg溶解挙動の結晶方位依存性の時間変化,撹拌の影響2017

    • Author(s)
      古田智,萩原幸司,大久保政欣,中野貴由,山崎倫昭
    • Organizer
      2017年度軽金属学会関西支部 若手研究者・院生による発表研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体インプラント用Ca-Mg-Zn基溶解性複相合金の溶解挙動制御2016

    • Author(s)
      石井健太郎,萩原幸司,中野貴由
    • Organizer
      軽金属学会関西支部 若手研究者・院生による研究発表会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2016-12-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 組織制御を介したCa-Mg-Zn基溶解性化合物複相合金の溶解特性制御2016

    • Author(s)
      石井健太郎,萩原幸司,中野貴由
    • Organizer
      軽金属学会 2016年度(第131回)秋期講演大会
    • Place of Presentation
      茨城大学水戸キャンパス
    • Year and Date
      2016-11-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ca-Mg-Zn基溶解性複相合金の組織と溶解挙動の相関2016

    • Author(s)
      石井健太郎,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2016 秋期講演大会
    • Place of Presentation
      大阪大学豊中キャンパス
    • Year and Date
      2016-09-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 結晶方位によるMg合金溶解挙動の制御2016

    • Author(s)
      萩原幸司,大久保政欣,山崎倫昭,中野貴由
    • Organizer
      軽金属学会 2016 春期講演大会
    • Place of Presentation
      大阪大学吹田キャンパス
    • Year and Date
      2016-05-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Ca-Mg-Zn系溶解性化合物複相合金の創成2016

    • Author(s)
      石井 健太郎,萩原 幸司,中野 貴由
    • Organizer
      軽金属学会 2016 春期講演大会
    • Place of Presentation
      大阪大学吹田キャンパス
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 組織制御によるCa-Mg-Zn 系溶解性化合物複相合金作製の試み2016

    • Author(s)
      石井 健太郎,萩原 幸司,中野 貴由
    • Organizer
      日本金属学会 2016 春期講演大会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規生体内溶解性材料としての(Ca,Mg,Zn)系化合物複相合金の創成2015

    • Author(s)
      石井健太郎,大久保政欣,萩原幸司,中野貴由
    • Organizer
      軽金属学会関西支部 若手研究者・院生による研究発表会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Ca-Mg-Zn系金属間化合物複相合金の溶解挙動2015

    • Author(s)
      石井健太郎,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2015 秋期講演大会
    • Place of Presentation
      九州大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mg固溶体単結晶の溶解挙動の結晶方位,組成依存性2015

    • Author(s)
      大久保政欣,萩原幸司,中野貴由
    • Organizer
      日本金属学会 2015 秋期講演大会
    • Place of Presentation
      九州大学
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi