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Development of low-fouling membrane for classification of proteins and its application

Research Project

Project/Area Number 15H04177
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Properties in chemical engineering process/Transfer operation/Unit operation
Research InstitutionKogakuin University

Principal Investigator

Nakao Shin-ichi  工学院大学, 先進工学部, 教授 (00155665)

Co-Investigator(Kenkyū-buntansha) 峰島 三千男  東京女子医科大学, 医学部, 教授 (50166097)
赤松 憲樹  工学院大学, 先進工学部, 准教授 (50451795)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords化学工学 / 膜 / ファウリング
Outline of Final Research Achievements

The classification of proteins is an important technique in the medical and pharmaceutical field, however fouling remains a critical issue to be solved. In this study, we successfully developed low-fouling membranes against proteins by employing the plasma graft polymerization method. The developed technique was effective for the polymeric flat-sheet membranes as well as hollow-type membranes. Furthermore, molecular weight cut-offs of the developed low-fouling membranes were successfully estimated with using dextrans and proteins.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Mass Transfer Coefficient of Tubular Ultrafiltration Membranes under High-Flux Conditions2018

    • Author(s)
      Kazuki Akamatsu, Keita Ishizaki, Shotaro Yoshinaga, Shin-ichi Nakao
    • Journal Title

      AIChE Journal

      Volume: in press Issue: 5 Pages: 1778-1782

    • DOI

      10.1002/aic.16052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limiting Flux in Microfiltration of Colloidal Suspensions by Focusing on Hydrodynamic Forces in Viscous Sublayer2018

    • Author(s)
      Ryo Makabe, Kazuki Akamatsu, Shin-ichi Nakao
    • Journal Title

      AIChE J.

      Volume: in press Issue: 5 Pages: 1760-1765

    • DOI

      10.1002/aic.16050

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Problems in the evaluation of polyvinylpyrrolidone (PVP) elution from polysulfone membrane dialyzers sterilized by gamma-ray irradiation.2016

    • Author(s)
      un Murakami, Iwakazu Kaneko, Naoki Kimata, Michio Mineshima and Takashi Akiba
    • Journal Title

      Renal Replacement Therapy

      Volume: 2 Issue: 1 Pages: 36-36

    • DOI

      10.1186/s41100-016-0047-x

    • NAID

      120006239221

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] クロスフロー精密ろ過における粒子ファウリングの抑制2017

    • Author(s)
      赤松憲樹
    • Organizer
      膜ファウリング研究会
    • Place of Presentation
      広島
    • Year and Date
      2017-01-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高分子成分・粒子状成分のファウリング(依頼講演)2017

    • Author(s)
      赤松憲樹
    • Organizer
      第39回高分子と水・分離に関する研究会講座
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラズマグラフト重合法を用いた低ファウリング限外ろ過膜の開発2017

    • Author(s)
      赤松憲樹,能登渉,福澤博之,中尾真一
    • Organizer
      化学工学会第49回秋季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カルボキシメチルベタインを用いた低ファウリング限外ろ過膜の分画特性2017

    • Author(s)
      赤松憲樹,能登渉,福澤博之,中尾真一
    • Organizer
      膜シンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高分子成分・粒子状成分のファウリング現象の理解に向けたアプローチ(依頼講演)2017

    • Author(s)
      赤松憲樹
    • Organizer
      SNAP研究会 2017年度事例研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 水処理における膜技術とファウリング抑制2016

    • Author(s)
      赤松憲樹
    • Organizer
      第85回武蔵野地区高分子懇話会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Clinical effectiveness of Intermittent Infusion Hemodiafiltration (IIHDF) using backfiltration of ultrapure dialysis fluid compared with Predilution On-line Hemodiafiltration: A prospective, multicenter and controlled trial.2016

    • Author(s)
      Mineshima, Michio, Kei Eguchi
    • Organizer
      American Society of Nephrology 2016 Renal Week.
    • Place of Presentation
      Chicago, US
    • Year and Date
      2016-11-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] Optimal design of the dialyzers. Scientific Aspects of Dialysis Therapy, JSDT/JSFA Anniversary Edition2017

    • Author(s)
      Mineshima, Michio
    • Total Pages
      6
    • Publisher
      KARGER
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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