Functional analysis of synaptic inputs from periphery and central brain regions in the plasticity of olfactory neural circuit
| Project/Area Number |
15H04256
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kochi University (2016-2018)
The University of Tokyo (2015) |
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Principal Investigator |
Yamaguchi Masahiro 高知大学, 教育研究部医療学系基礎医学部門, 教授 (60313102)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 嗅球 / 新生ニューロン / 生死選別 / スパイン発達 / 末梢性シナプス入力 / 中枢性シナプス入力 / 嗅皮質 / 神経新生 / 匂い入力 / 中枢性入力 |
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| Outline of Final Research Achievements |
Even in the adult, new neurons are generated in the olfactory bulb and are selected between survival and death. By using mice as model animals, we previously revealed that this selection of new neurons is directed by the combination of synaptic inputs from periphery reflecting odor experience and synaptic inputs from central brain regions. In this project, we manipulated the individual synaptic inputs by using optogenetic and pharmacogenetic techniques, and revealed that association of peripheral synaptic inputs and reward learning facilitates development of new neurons. We further suggested that centrally-mediated synaptic inputs are involved in this facilitation of new neurons by association learning.
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| Academic Significance and Societal Importance of the Research Achievements |
新しいニューロンは周りのニューロンとの相互作用のなかで働いている。したがって、ニューロンの相互作用を担うシナプス入力の役割を理解することは、新しいニューロンを有効に活用して脳機能を高める方法を考える上で極めて重要である。新しいニューロンの発達を促進するシナプス機構の理解は、脳の発達・成長を担う基本メカニズムを明らかにするだけでなく、教育や再生医療においても大きく貢献すると考えられる。
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS2017
Author(s)
Ochi T, Kawaguchi T, Nakahara T, Ono M, Noguchi S, Koshiyama Y, Munekage K, Murakami E, Hiramatsu A, Ogasawara M, Hirose A, Mizuta H, Masuda K, Okamoto N, Suganuma N, Chayama K, Yamaguchi M, Torimura T, Saibara T
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 10146-10146
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression.2017
Author(s)
Klein D, Steens J, Wiesemann A, Schulz FC, Kaschani F, Roeck K, Yamaguchi M, Wirsdorfer F, Kaiser M, Fischer J, Stuschke M, Jendrossek V.
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Journal Title
Antioxidant & Redox Signaling
Volume: 26
Issue: 11
Pages: 563-582
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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