Role of synaptic plasticity-related gene Arc on regulating cognitive function in the brain
Project/Area Number |
15H04258
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Kagoshima University (2018) Kyoto University (2015-2017) |
Principal Investigator |
Hiroyuki OKUNO 鹿児島大学, 医歯学域医学系, 教授 (80272417)
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Research Collaborator |
Imayoshi Itaru
Bito Haruhiko
Hirano Yukinori
Amaya Victor Ramirez
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | シナプス可塑性 / 記憶 / 遺伝子発現 / 活動依存的遺伝子発現 / シナプス / 可塑性 / 脳・神経 / 海馬 / Arc / 神経科学 / 認知機能 |
Outline of Final Research Achievements |
The synapse, a site of communication between two neurons, operates as a minimal functional unit that underlies a variety of cognitive functions including learning and memory. This study aims to investigate the molecular basis of synaptic regulation through a gene called, Arc, whose expression is regulated in turn by synaptic activities. Our analysis revealed that Arc is involved in for formation and maintenance of long-term memory as well as experience-dependent neural plasticity. Furthermore, we found that Arc-expressing neurons in the hippocampus play a critical role for retrieval of a month-old memory in mice. Our results suggest a fundamental role of Arc in cognitive function in the brain.
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Academic Significance and Societal Importance of the Research Achievements |
記憶の形成、維持および想起メカニズムは古くより学術的な興味対象として多くの研究者によって調べられてきましたが、その分子機構に関してはいまだに多くが未解明のままで残されています。本研究ではArcという遺伝子による新しい分子制御モデルを提唱し、それが実際の大脳で起こっていることを明らかにしました。記憶や認知機能の分子的基盤解明は発達障害や認知症などに対する新たな治療法および予防策に役に立つと考えられます。
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Report
(5 results)
Research Products
(53 results)
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[Journal Article] Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the Arc gene2019
Author(s)
Kikuchi K, Ihara D, Fukuchi M, Tanabe H, Ishibashi Y, Tsujii J, Tsuda M, Kaneda M, Sakagami H, Okuno H, Bito H, Yamazaki Y, Ishikawa M, Tabuchi A.
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Journal Title
J Neurochem
Volume: 148
Pages: 204-218
DOI
Related Report
Peer Reviewed
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[Journal Article] Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice2019
Author(s)
Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T.
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Journal Title
Neuropsychopharmacol Rep
Volume: 39
Pages: 61-66
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility2018
Author(s)
Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T.
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Journal Title
J Neurosci
Volume: 38
Pages: 10220-10235
DOI
Related Report
Peer Reviewed
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[Journal Article] Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.2016
Author(s)
Hirano, Y., Ihara, K., Masuda, T., Yamamoto T., Iwata, I., Takahashi, A., Awata, H., Nakamura, N., Takakura, M., Suzuki, Y., Horiuchi, J., Okuno, H., Saitoe, M.
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Journal Title
Nature Communications
Volume: 7
Pages: 13471
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Whole-brain mapping of behaviorally-induced neural activation in mice.2015
Author(s)
Vousden DA, Epp J, Okuno H, Nieman BJ, van Eede M, Dazai J, Ragan T, Bito H, Frankland PW, Lerch JP, Henkelman RM.
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Journal Title
Brain Struc Func
Volume: 220
Pages: 2043-2057
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Class I Histone deacetylase-mediated repression of the proximal promoter of the activity-regulated cytoskeleton-associated protein gene regulates its response to brain-derived neurotrophic factor.2015
Author(s)
Fukuchi, M., Nakashima, F., Tabuchi, A.,Shimotori, M., Tatsumi, S., Okuno, H., Bito, H., Tsuda, M.
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Journal Title
J Biol Chem.
Volume: 290
Pages: 6825-6836
DOI
Related Report
Peer Reviewed
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[Presentation] Specification of a remote memory cell ensemble during cortical tagging2018
Author(s)
Kim R, Kondo Y, Kawashima T, Inoue M, Ishii Y, Inokuchi K, Sakai K, Nonaka M, Sakamoto H, Okuno H, Bito H.
Organizer
Soc for Neurosci Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Roles of Arc/arg3.1 on surface expression dynamics of AMPA receptors during structural plasticity and on cognitive refinement processes.2017
Author(s)
Okuno H, Ishii Y, Endo T, Uehara M, Suzuki Y, Minatohara K, Araki A, Abe M, Imayoshi I, Kakeyama M, Sakimura K, Bito H
Organizer
Soc for Neurosci. Annual Meeting 2017 (Neuroscience 2017)
Related Report
Int'l Joint Research
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[Presentation] Increased spine density in Arc-expressing neurons after contextual fear memory retrieval in the mouse hippocampus2016
Author(s)
K. Minatohara, K., Akiyoshi, M., Takahashi, Y., Bito, H., Okuno, H.
Organizer
Society for Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2016-11-12 – 2016-11-16
Related Report
Int'l Joint Research
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[Presentation] Critical roles of CREB-Arc signaling in fear memory formation2016
Author(s)
Kim, R., Sakai, K., Kawashima, T., Nonaka, M., Goto, M., Koyama, H., Kobari, S., Imayoshi, I., Okuno, H., Bito, H.
Organizer
第39回日本神経科学大会
Place of Presentation
パシフィコ横浜(横浜)
Year and Date
2016-07-20 – 2016-07-22
Related Report
Invited
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