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Clarifying the neural basis of social reward processing

Research Project

Project/Area Number 15H04262
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Physiological Sciences (2016-2017)
Kansai Medical University (2015)

Principal Investigator

ISODA MASAKI  生理学研究所, システム脳科学研究領域, 教授 (90466029)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords自己 / 他者 / サル / 単一神経細胞活動 / 前頭葉内側皮質細胞 / ドーパミン細胞 / 報酬 / 社会 / 中脳ドーパミン神経細胞 / 単一神経細胞活動記録 / 神経科学 / 生理学 / 動物 / 脳・神経 / ドーパミン神経細胞 / 前頭葉内側皮質 / 自他比較
Outline of Final Research Achievements

Human behaviors are influenced by not only rewards for oneself, but also rewards for others. To investigate neuronal mechanisms underlying reward processing in social contexts, we devised a social Pavlovian conditioning procedure for two monkeys facing each other and monitored single-unit activity in the medial prefrontal cortex (MPFC) and dopaminergic midbrain nuclei. We found that single MPFC neurons selectively encode self-reward information or partner’s reward information, whereas single dopamine neurons encode a subjective value. These findings suggest that cortico-subcortical networks play an important role in reward processing in social contexts.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (40 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (28 results) (of which Int'l Joint Research: 17 results,  Invited: 16 results) Book (2 results)

  • [Int'l Joint Research] NIH(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Direct and indirect pathways for choosing objects and actions2018

    • Author(s)
      Okihide Hikosaka, Hyoung Kim, Hidetoshi Amita, Masaharu Yasuda, Masaki Isoda, Yoshihisa Tachibana, Atsushi Yoshida
    • Journal Title

      European Journal of Neuroscience

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] マカクザルの自己認知と自他区別2017

    • Author(s)
      磯田昌岐&宮崎美智子
    • Journal Title

      生体の科学

      Volume: なし

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Understanding intentional actions from obserevers’ viewpoints: A social neuroscience perspective.2016

    • Author(s)
      Isoda M
    • Journal Title

      Neuroscience Research

      Volume: 112 Pages: 1-9

    • DOI

      10.1016/j.neures.2016.06.008

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Single-neuron and genetic correlates of autistic behavior in macaque2016

    • Author(s)
      K. Yoshida, Y. Go, I. Kushima, A. Toyoda, A. Fujiyama, H. Imai, N. Saito, A. Iriki, N. Ozaki, M. Isoda
    • Journal Title

      Science Advances

      Volume: 2 Issue: 9

    • DOI

      10.1126/sciadv.1600558

    • NAID

      120006222007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A primary role for nucleus accumbens and related limbic network in vocal tics.2016

    • Author(s)
      McCairn KW, Nagai Y, Hori Y, Ninomiya T, Kikuchi E, Lee J-Y, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M
    • Journal Title

      Neuron

      Volume: 89 Issue: 2 Pages: 300-307

    • DOI

      10.1016/j.neuron.2015.12.025

    • NAID

      120005997652

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 霊長類の神経生理学研究からみた「他者理解」2016

    • Author(s)
      磯田昌岐
    • Journal Title

      精神医学

      Volume: 58 Pages: 7-13

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 帯状皮質運動野2015

    • Author(s)
      吉田今日子,磯田昌岐
    • Journal Title

      脳科学辞典

      Volume: -

    • DOI

      10.14931/bsd.2404

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Common therapeutic mechanisms of pallidal deep brain stimulation for hypo- and hyperkinetic movement disorders2015

    • Author(s)
      McCairn KW, Iriki A, Isoda M
    • Journal Title

      Journal of Neurophysiology

      Volume: 114 Issue: 4 Pages: 2090-2104

    • DOI

      10.1152/jn.00223.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 補足眼野2015

    • Author(s)
      吉田今日子,磯田昌岐
    • Journal Title

      脳科学辞典

      Volume: -

    • DOI

      10.14931/bsd.2087

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Phenotype-Driven Cognitive Genomics in the Macaque: A Naturally Occurring Case of Autistic Disorder2017

    • Author(s)
      磯田昌岐
    • Organizer
      2017 Yonsei-Korea-NIPS Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social reward monitoring in the macaque brain2017

    • Author(s)
      Isoda M
    • Organizer
      CSH-Asia Primate Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Towards a systems-level understanding of social brain function2017

    • Author(s)
      Isoda M
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Phase-amplitude coupling in cerebro-basal ganglia-cerebellar networks: A new model of hypo- and hyperkinetic movement disorders2017

    • Author(s)
      Ninomiya T, Nagai Y, Inoue K, Hori Y, Kikuchi E, Lee JY, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M, Maccairn K
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cortico-subcortical mechanisms underlying social reward monitoring in the macaque2017

    • Author(s)
      Isoda M
    • Organizer
      McGill-NIPS Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Probing the social mind with an electrode2017

    • Author(s)
      Isoda M
    • Organizer
      第44回内藤コンファレンス
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 集団的フロネシスの発現と創発の解明を目指して2017

    • Author(s)
      磯田昌岐
    • Organizer
      平成28年度京都大学霊長類研究所共同利用研究会
    • Place of Presentation
      京都大学霊長類研究所(愛知県犬山市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 霊長類動物を用いて高次脳機能の統合的理解をめざす実験研究のストラテジー2016

    • Author(s)
      磯田昌岐
    • Organizer
      生理学研究所所長招聘セミナー
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-02-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Probing the social mind with an electrode2016

    • Author(s)
      Isoda M
    • Organizer
      第3回CiNet国際カンファレンス
    • Place of Presentation
      CiNet(大阪府吹田市)
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 霊長類動物を対象とした認知ゲノミクス研究2016

    • Author(s)
      磯田昌岐
    • Organizer
      国際高等研究所研究会
    • Place of Presentation
      国際高等研究所(京都府木津川市)
    • Year and Date
      2016-01-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Phenotype-driven cognitive genomics: a case of an autistic monkey2016

    • Author(s)
      Isoda M
    • Organizer
      PRI Mini-Symposium”Recent advances in the development of nonhuman primate models for brain
    • Place of Presentation
      京都大学霊長類研究所(愛知県犬山市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Genetic and neuronal correlates of autistic behavior in the macaque2016

    • Author(s)
      磯田昌岐
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Activity of primate dopamine neurons is influenced by the prospect of others' reward2016

    • Author(s)
      Noritake A, Isoda M
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サルの社会脳研究からみたドーパミンシグナル2016

    • Author(s)
      磯田昌岐
    • Organizer
      第31回日本大脳基底核研究会
    • Place of Presentation
      秋田温泉さとみ(秋田県秋田市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 霊長類動物を用いた社会脳研究:ニューロンは自己と他者の情報をどの ように表現するか2016

    • Author(s)
      磯田昌岐
    • Organizer
      日本学術会議「脳と意識」・「神経科学」・「脳とこころ」 分科会合同 市民公開シンポジウム
    • Place of Presentation
      日本学術会議講堂(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 自己と他者の報酬情報処理にかかわるサルの皮質・皮質下ネットワーク2016

    • Author(s)
      磯田昌岐
    • Organizer
      第6回生理学研究所・名古屋大学医学系研究科 合同シンポジウム
    • Place of Presentation
      名古屋大学医学系研究科(愛知県名古屋市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Phenotypo-Driven Cognitive Genomics in the Macaque: A Naturally Occurring Case of Autistic Disorder2016

    • Author(s)
      Isoda M
    • Organizer
      6th Joint CIN-NIPS Symposium
    • Place of Presentation
      Tubingen (Germany)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social reward signals in primate lateral hypothalamic neurons: comparison with prefrontal and midbrain dopamine neurons2016

    • Author(s)
      Noritake A, Isoda M
    • Organizer
      Neuroscience2016
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prominent phase-amplitude cross-frequency coupling between alpha and gamma oscillations underlies motor-tic encoding in cerebro-basal ganglia-cerebellar networks2016

    • Author(s)
      Ninomiya T, Nagai Y, Suhara T, Minamimoto T, Takada M, Matsumoto M, Isoda M, K.W.McCairn
    • Organizer
      Neuroscience2016
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自己と他者の報酬情報処理におけるドーパミン神経細胞の役割2016

    • Author(s)
      磯田昌岐
    • Organizer
      第1回脳情報の解読と制御研究会& 第3回自発脳活動研究会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県別府市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Phenotype-driven cognitive genomics: a naturally occurring case of autistic disorder in the macaque.2016

    • Author(s)
      Isoda M
    • Organizer
      Brain/MINDS International Symposium
    • Place of Presentation
      東京大学農学部弥生講堂(東京都文京区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 社会性からみた”かしこさ”の神経メカニズムと遺伝子基盤を探る2016

    • Author(s)
      磯田昌岐
    • Organizer
      第13回NBR公開シンポジウム
    • Place of Presentation
      御茶ノ水ソラシティカンファレンスセンター (東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 社会的認知機能の生理学的理解:サル類を用いた実験研究から2015

    • Author(s)
      磯田昌岐
    • Organizer
      第19回実験社会科学カンファレンス
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 霊長類動物を対象とする社会システム神経科学2015

    • Author(s)
      磯田昌岐
    • Organizer
      日本神経回路学会オータムスクールASCONE2015
    • Place of Presentation
      かたくら諏訪湖ホテル(長野県諏訪市)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Social reward valuation in primate midbrain dopamine cells2015

    • Author(s)
      Noritake A, Isoda M
    • Organizer
      第45回北米神経科学学会
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spontaneously emerging parkinsonism-cerebellar syndrome in a subspecies of Japanese macaque (macaca fuscata yakui): A potential analogue of multiple system atrophy2015

    • Author(s)
      McCairn KW, Nagai Y, Kimura K, Go Y, Inoue K, Isoda M, Minamimoto T, Matsumoto M, Ninomiya T, Takada M
    • Organizer
      第45回北米神経科学学会
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparative analysis of vocal and myoclonic tics in a monkey model of Tourette syndrome: a PET and electrophysiological study2015

    • Author(s)
      McCairn KW, Nagai Y, Hori Y, Kikuchi E, Suhara T, Minamimoto T, Iriki A, Takada M, Isoda M, Matsumoto M
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Probing social brain functions using an electrode2015

    • Author(s)
      Isoda M
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] The Prefrontal Cortex as an Executive, Emotional, and Social Brain2017

    • Author(s)
      Isoda M
    • Total Pages
      276
    • Publisher
      Springer
    • ISBN
      9784431565062
    • Related Report
      2017 Annual Research Report
  • [Book] The Prefrontal Cortex as an Executive, Emotional, and Social Brain (Self-other differentiation and monitoring others' actions in the medial prefrontal cortex of the monkey)2017

    • Author(s)
      Isoda M
    • Total Pages
      276
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-09-26  

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