Clarifying the neural basis of social reward processing
| Project/Area Number |
15H04262
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | National Institute for Physiological Sciences (2016-2017)
Kansai Medical University (2015) |
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Principal Investigator |
ISODA MASAKI 生理学研究所, システム脳科学研究領域, 教授 (90466029)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 自己 / 他者 / サル / 単一神経細胞活動 / 前頭葉内側皮質細胞 / ドーパミン細胞 / 報酬 / 社会 / 中脳ドーパミン神経細胞 / 単一神経細胞活動記録 / 神経科学 / 生理学 / 動物 / 脳・神経 / ドーパミン神経細胞 / 前頭葉内側皮質 / 自他比較 |
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| Outline of Final Research Achievements |
Human behaviors are influenced by not only rewards for oneself, but also rewards for others. To investigate neuronal mechanisms underlying reward processing in social contexts, we devised a social Pavlovian conditioning procedure for two monkeys facing each other and monitored single-unit activity in the medial prefrontal cortex (MPFC) and dopaminergic midbrain nuclei. We found that single MPFC neurons selectively encode self-reward information or partner’s reward information, whereas single dopamine neurons encode a subjective value. These findings suggest that cortico-subcortical networks play an important role in reward processing in social contexts.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] A primary role for nucleus accumbens and related limbic network in vocal tics.2016
Author(s)
McCairn KW, Nagai Y, Hori Y, Ninomiya T, Kikuchi E, Lee J-Y, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M
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Journal Title
Neuron
Volume: 89
Issue: 2
Pages: 300-307
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Phase-amplitude coupling in cerebro-basal ganglia-cerebellar networks: A new model of hypo- and hyperkinetic movement disorders2017
Author(s)
Ninomiya T, Nagai Y, Inoue K, Hori Y, Kikuchi E, Lee JY, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M, Maccairn K
Organizer
第40回日本神経科学大会
Related Report
Int'l Joint Research
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