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Acquisition and consolidation of spatial memory by hippocampal predicitve computation

Research Project

Project/Area Number 15H04265
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Fukai Tomoki  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (40218871)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords自発発火 / 樹状突起 / 学習と記憶 / 神経回路モデル / シナプス可塑性 / ベイズ推定 / 回路構造 / カルシウムスパイク / 領野間連絡 / 海馬 / 正準相関解析 / ノンレム睡眠 / UP-DOWN状態遷移 / 計算論的モデル / 構造シナプス可塑性 / プレプレイ / リプレイ / カルシウム・スパイク / 領野間相互作用 / 空間学習 / シナプス構造可塑性 / 海馬場所細胞 / プリプレイ / 計算理論
Outline of Final Research Achievements

We studied an inference task model to demonstrate that an adequate network structure naturally emerges from dual Hebbian learning for both synaptic weight plasticity and wiring plasticity. Especially in a sparsely connected network, wiring plasticity achieves reliable computation by enabling efficient information transmission. We constructed a cortical network model of UP-DOWN transitions to indicate the role of persistent UP states for the prolonged repetition of a selected set of cell assemblies during memory
consolidation. We proposed a network model of sequence learning which instantiates two synaptic pathways, one for proximal dendrite-somatic interactions to generate spontaneous sequences and the other for distal dendritic processing of extrinsic signals. The model performs robust one-shot learning of spatial memory. We showed that redundant synaptic connections between a neuron pair enable near-optimal learning by approximating a sample-based Bayesian filtering algorithm.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (33 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 21 results,  Invited: 12 results) Book (1 results)

  • [Journal Article] Detailed Dendritic Excitatory/Inhibitory Balance through Heterosynaptic Spike-Timing-Dependent Plasticity2017

    • Author(s)
      Hiratani Naoki、Fukai Tomoki
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Issue: 50 Pages: 12106-12122

    • DOI

      10.1523/jneurosci.0027-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medial frontal circuit dynamics represents probabilistic choices for unfamiliar sensory experience2017

    • Author(s)
      Takashi Handa, Takashi Takekawa, Rie Harukuni, Yoshikazu Isomura, and Tomoki Fukai
    • Journal Title

      Cerebral Cortex

      Volume: Feb. 10 Issue: 7 Pages: 1-14

    • DOI

      10.1093/cercor/bhx031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hebbian Wiring Plasticity Generates Efficient 1 Network Structures for Robust Inference with Synaptic Weight Plasticity2016

    • Author(s)
      Naoki Hiratani, Tomoki Fukai
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 10 Pages: 1-19

    • DOI

      10.3389/fncir.2016.00041

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hebbian Wiring Plasticity Generates Efficient Network Structures for Robust Inference with Synaptic Weight Plasticity2016

    • Author(s)
      Naoki Hiratani, Tomoki Fukai
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A lognormal recurrent network model for burst generation during hippocampal sharp waves2015

    • Author(s)
      Omura Y., Carvalho M., Inokuchi K. and Fukai T.
    • Journal Title

      J. Neurosci.

      Volume: 35 Issue: 43 Pages: 14585-14601

    • DOI

      10.1523/jneurosci.4944-14.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Dendritic canonical correlation analysis for memory and sensory information processing2018

    • Author(s)
      Tomoki Fukai
    • Organizer
      Dendritic integration and computation with active dendrites
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sequence learning through reverse replay and preplay in hippocampal circuit models2018

    • Author(s)
      Tomoki Fukai
    • Organizer
      Institut d’Investigacions Biom?diques August Pi i Sunyer (IDIBAPS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Information transfer during slow oscillations in cortical networks2018

    • Author(s)
      Tomoki Fukai
    • Organizer
      The 4th CiNet Conference "Neural oscillation and functional connectivity:from anatomy to perception"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 相互に教え合うリザーバ計算モジュールによるチャンク学習2018

    • Author(s)
      朝吹俊丈, 平谷直輝, 深井朋樹
    • Organizer
      日本物理学会 第73回年次大会(2018年)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dendritic computing gives a meso-scopic level framework of brain's leaning rule2017

    • Author(s)
      Tatsuya Haga and Tomoki Fuka
    • Organizer
      Forum on Cognitive Neuroscience in Hangzhou
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 2コンパートメントニューラルネットワークモデルにおける頑健なシーケンス記憶の形成 Robust formation of sequential memory in two-compartment neural network model2017

    • Author(s)
      芳賀 達也 / Tatsuya Haga, 深井 朋樹 / Tomoki Fukai
    • Organizer
      Neuroscience2017 第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 順伝播型深層神経回路網における樹状突起の計算 Dendritic computing in deep feedforward neural networks2017

    • Author(s)
      鈴木 堅斗 / Kento Suzuki:1,2 芳賀 達也 / Tatsuya Haga:2 深井 朋樹 / Tomoki Fukai
    • Organizer
      Neuroscience2017 第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外界をモデル化する脳の回路メカニズム ―海馬と大脳皮質2017

    • Author(s)
      深井朋樹
    • Organizer
      第54回 脳科学ライフサポート研究センターセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質と海馬の神経集団活動から読み解く回路機能2017

    • Author(s)
      深井朋樹
    • Organizer
      平成29年度生理学研究所研究会「大脳皮質回路の機能原理を探る」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Reverse replay strengthens forward pathways to reward through Hebbian learning and short-term depression2017

    • Author(s)
      Tatsuya Haga, Tomoki Fukai
    • Organizer
      Neuroscience 2017 (SfN's 47th annual meeting)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal learning with redundant synaptic connections2016

    • Author(s)
      Naoki Hiratani, Tomoki Fukai
    • Organizer
      Neuroscience 2016 (SfN's 46th annual meeting)
    • Place of Presentation
      San Diego, CA., U.S.A.
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Autonomous internal dynamics of cortical circuits and its role in encoding spatial information2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      Bi-Weekly Seminar Series, NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dendritic canonical correlation analysis in vision and memory2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      Vision over vision: man, monkey, machine, and network models
    • Place of Presentation
      大阪大学、大阪府
    • Year and Date
      2016-10-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短期・長期可塑性を持つリカレントネットワークにおける逆行リプレイは報酬への順方向経路を増強する2016

    • Author(s)
      芳賀 達也、深井 朋樹
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Network models, synaptic plasticity, and spatial navigation: two pedagogical lectures and one research seminar2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      Computational Approaches to Memory and Plasticity. National Center for Biological Sciences
    • Place of Presentation
      Bangalore, India
    • Year and Date
      2016-07-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The hippocampal recurrent neural network model for replay, reverse replay, and preplay2016

    • Author(s)
      Tatsuya Haga, Tomoki Fukai
    • Organizer
      Modeling Neural Activity: Statistics, Dynamical Systems, and Networks
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal sampling with redundant synapses2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      Modeling Neural Activity: Statistics, Dynamical Systems, and Networks
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural and synaptic dynamics for memory2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      OIST Computational Neuroscience Course 2016
    • Place of Presentation
      OISTシーサイドハウス、沖縄県
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of external world by stochastic synapses and neurons2016

    • Author(s)
      Tomoki Fukai
    • Organizer
      Workshop on High-Performance Computing, Stochastic Modeling and Database in Neuroscience
    • Place of Presentation
      Sao Paulo, Brazil
    • Year and Date
      2016-04-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 冗長なシナプス結合による最適学習2016

    • Author(s)
      平谷直輝、深井朋樹
    • Organizer
      日本物理学会第71回年次大会
    • Place of Presentation
      東北学院大学 泉キャンパス
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Apical dendrite as a canonical correlation analyzer2016

    • Author(s)
      Tatsuya Haga, Tomoki Fukai
    • Organizer
      Computational and Systems Neuroscience Meeting (COSYNE) 2016
    • Place of Presentation
      Salt Lake City, UT.,USA
    • Year and Date
      2016-02-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synaptic plasticity with dendritic computing achieves the association of preplay patterns and place fields in hippocampus2015

    • Author(s)
      Tatsuya Haga, Tomoki Fukai
    • Organizer
      Neuroscience 2015 (SfN's 45th annual meeting)
    • Place of Presentation
      Chicago, Il., U.S.A.
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Burst generation and propagation during hippocampal sharp waves in a lognormal recurrent network model2015

    • Author(s)
      Tomoki Fukai, Yoshiyuki Omura, Milena M. Carvalho, Kaoru Inokuchi
    • Organizer
      Neuroscience 2015 (SfN's 45th annual meeting)
    • Place of Presentation
      Chicago, Il., U.S.A.
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 樹状突起の近位・遠位における正準相関分析2015

    • Author(s)
      芳賀達也、深井朋樹
    • Organizer
      第25回日本神経回路学会全国大会
    • Place of Presentation
      電気通信大学、東京
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] GABA driven circuit formation through heterosynaptic spike-timing-dependent plasticity2015

    • Author(s)
      Naoki Hiratani, Tomoki Fukai
    • Organizer
      Neural Coding, Computation and Dynamics (NCCD)
    • Place of Presentation
      Bilbao, Spain
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fat Tail Dynamics in the Brain, Part-1: Network Dynamics, Part-2: Synaptic Plasticity2015

    • Author(s)
      Tomoki Fukai
    • Organizer
      IEEE CIS Summer School on Neuromorphic and Cyborg Intelligent Systems
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 海馬における内部時空間活動パターンに関連付けられたPlace Fieldの経験依存的獲得2015

    • Author(s)
      芳賀達也、深井朋樹
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] The Rewiring Brain2017

    • Author(s)
      eds. Arjen van Ooyen and Markus Butz-Ostendorf
    • Total Pages
      592
    • Publisher
      Academic Press
    • ISBN
      9780128037843
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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