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Comprehensive analysis of brain mechanisms for active touch

Research Project

Project/Area Number 15H04266
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionOsaka University (2017-2018)
Kyoto University (2015-2016)

Principal Investigator

Furuta Takahiro  大阪大学, 歯学研究科, 講師 (60314184)

Co-Investigator(Kenkyū-buntansha) 田中 琢真  滋賀大学, データサイエンス学部, 准教授 (40526224)
Research Collaborator Hioki Hiroyuki  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywordsシゲシステム / 運動制御 / 感覚情報処理 / アクティブタッチ / 回路構造 / システム神経科学 / ヒゲシステム / 神経回路構築 / 触覚 / 情報符号化 / 末梢 / 機械受容器 / 軸索内記録
Outline of Final Research Achievements

To investigate mechanisms of active touch, we need to integrate multiple research approaches which cover broad fields including motor control and sensory processing. This project exploits rodent vibrissal system which is the very excellent tactile apparatus. Because rats actively move their vibrissae and touch objects by the vibrissae, this system is a good model for active touch system. Here, we performed three subprojects.
<Subproject 1>: We revealed correlations between structures and activities of motor control circuits in the cortex and superior colliculus. <Subproject 2>: We revealed coding and transduction properties of identified primary tactile afferents. <Subproject 3>: We revealed the influence of the corticothalamic pathways on the firing mode and sensory gain of thalamic neurons.

Academic Significance and Societal Importance of the Research Achievements

一つのシステムの中に感覚受容と運動制御の要素を同梱しているヒゲシステムを利用し、形態学的解析を軸としながら生理学的解析などの方法とも有機的に組み合わせてメカニズムの本質に迫る結果が得られた点は意義深い。形態学的データについては、これまで他の研究の基盤となるべき知見が不足していた状況であったが、本研究では中枢から末梢にかけて信頼性の高い形態学的構築のデータを提供した点で重要である。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (37 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (7 results) Journal Article (18 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 18 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (10 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Northwestern University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Northwestern University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Northwestern University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Laval University(Canada)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Weizmann Institute of Science(Israel)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Laval Univ(CANADA)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] UCSD(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Expression of cholecystokinin by neurons in mouse spinal dorsal horn2019

    • Author(s)
      Gutierrez-Mecinas Maria、Bell Andrew M.、Shepherd Fraser、Polgar Erika、Watanabe Masahiko、Furuta Takahiro、Todd Andrew J.
    • Journal Title

      Journal of Comparative Neurology

      Volume: - Issue: 11 Pages: 1857-1871

    • DOI

      10.1002/cne.24657

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord2019

    • Author(s)
      Gutierrez-Mecinas Maria、Davis Olivia、Polgar Erika、Shahzad Mahvish、Navarro-Batista Keila、Furuta Takahiro、Watanabe Masahiko、Hughes David I.、Todd Andrew J.
    • Journal Title

      Neuroscience

      Volume: 398 Pages: 171-181

    • DOI

      10.1016/j.neuroscience.2018.12.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Descending Circuit Derived From the Superior Colliculus Modulates Vibrissal Movements2018

    • Author(s)
      Kaneshige Miki、Shibata Ken-ichi、Matsubayashi Jun、Mitani Akira、Furuta Takahiro
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 12 Pages: 100-100

    • DOI

      10.3389/fncir.2018.00100

    • NAID

      120006645288

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Projection Patterns of Corticofugal Neurons Associated with Vibrissa Movement2018

    • Author(s)
      Shibata Ken-Ichi、Tanaka Takuma、Hioki Hiroyuki、Furuta Takahiro
    • Journal Title

      eneuro

      Volume: 5 Issue: 5 Pages: 0190-18

    • DOI

      10.1523/eneuro.0190-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical and Subcortical Projections from Granular Insular Cortex Receiving Orofacial Proprioception2018

    • Author(s)
      Tsutsumi Yumi、Tachibana Yoshihisa、Sato Fumihiko、Furuta Takahiro、Ohara Haruka、Tomita Akiko、Fujita Masatoshi、Moritani Masayuki、Yoshida Atsushi
    • Journal Title

      Neuroscience

      Volume: 388 Pages: 317-329

    • DOI

      10.1016/j.neuroscience.2018.07.047

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcortical descending pathways through granular insular cortex conveying orofacial proprioception2018

    • Author(s)
      Ikenoue Etsuko、Akhter Fatema、Tsutsumi Yumi、Sato Fumihiko、Ohara Haruka、Uchino Katsuro、Furuta Takahiro、Tachibana Yoshihisa、Yoshida Atsushi
    • Journal Title

      Brain Res.

      Volume: 1687 Pages: 11-19

    • DOI

      10.1016/j.brainres.2018.02.033

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy2018

    • Author(s)
      Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
    • Journal Title

      Stem Cell Rep

      Volume: 10 Issue: 2 Pages: 356-365

    • DOI

      10.1016/j.stemcr.2017.12.001

    • NAID

      120006414715

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shaping somatosensory responses in awake rats: cortical modulation of thalamic neurons2017

    • Author(s)
      Hirai Daichi、Nakamura Kouichi C.、Shibata Ken-ichi、Tanaka Takuma、Hioki Hiroyuki、Kaneko Takeshi、Furuta Takahiro
    • Journal Title

      Brain Structure and Function

      Volume: 223 Issue: 2 Pages: 851-872

    • DOI

      10.1007/s00429-017-1522-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dorsal and ventral parts of thalamic nucleus submedius project to different areas of rat orbitofrontal cortex: A single neuron-tracing study using virus vectors.2017

    • Author(s)
      Kuramoto E, Iwai H, Yamanaka A, Ohno S, Seki H, Tanaka YR, Furuta T, Hioki H, Goto T
    • Journal Title

      J Comp Neurol.

      Volume: 525 Issue: 18 Pages: 3821-3839

    • DOI

      10.1002/cne.24306

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord.2017

    • Author(s)
      Boyle KA, Gutierrez-Mecinas M, Polgar E, Mooney N, O'Connor E, Furuta T, Watanabe M, Todd AJ.
    • Journal Title

      Neuroscience

      Volume: 363 Pages: 120-133

    • DOI

      10.1016/j.neuroscience.2017.08.044

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Single Vector Platform for High-Level Gene Transduction of Central Neurons: Adeno-Associated Virus Vector Equipped with the Tet-Off System.2017

    • Author(s)
      Sohn J, Takahashi M, Okamoto S, Ishida Y, Furuta T, Hioki H.
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 1 Pages: e0169611-e0169611

    • DOI

      10.1371/journal.pone.0169611

    • NAID

      120005954461

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Individual Mediodorsal Thalamic Neurons Project to Multiple Areas of the Rat Prefrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors.2017

    • Author(s)
      Kuramoto E, Pan SX, Furuta T, Tanaka YR, Iwai H, Yamanaka A, Ohno S, Kaneko T, Goto T, Hioki H.
    • Journal Title

      J Comp Neurol

      Volume: 525 Issue: 1 Pages: 166-185

    • DOI

      10.1002/cne.24054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Preprotachykinin A (PPTA) is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal including cells that respond to noxious and pruritic stimuli.2017

    • Author(s)
      Gutierrez-Mecinas M, Bell AM, Marin A, Taylor R, Boyle K, Furuta T, Watanabe M, Polg&aacute;r E, Todd AJ
    • Journal Title

      Pain

      Volume: 158 Issue: 3 Pages: 440-456

    • DOI

      10.1097/j.pain.0000000000000778

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition, Not Excitation, Drives Rhythmic Whisking.2016

    • Author(s)
      Deschenes M, Takatoh J, Kurnikova A, Moore JD, Demers M, Elbaz M, Furuta T, Wang F, Kleinfeld D
    • Journal Title

      Neuron

      Volume: 90 Issue: 2 Pages: 374-387

    • DOI

      10.1016/j.neuron.2016.03.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A single-neuron tracing study of arkypallidal and prototypic neurons in healthy rats.2016

    • Author(s)
      Fujiyama F, Nakano T, Matsuda W, Furuta T, Udagawa J, Kaneko T
    • Journal Title

      Brain Struct Funct

      Volume: 221 Pages: 4733-4740

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarity in neuronal firing regimes across mammalian species2016

    • Author(s)
      Yasuhiro Mochizuki, ..., Ichiro Fujita, et al.
    • Journal Title

      Journal of Neuroscience

      Volume: 36 Issue: 21 Pages: 5736-5747

    • DOI

      10.1523/jneurosci.0230-16.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Simple and Efficient In Vivo Non-viral RNA Transfection Method for Labeling the Whole Axonal Tree of Individual Adult Long-Range Projection Neurons.2016

    • Author(s)
      Porrero C, Rodriguez-Moreno J, Quetglas JI, Smerdou C, Furuta T, Clasca F
    • Journal Title

      Front Neuroanat.

      Volume: 10 Pages: 27-27

    • DOI

      10.3389/fnana.2016.00027

    • NAID

      120005947004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inhibition, Not Excitation, Drives Rhythmic Whisking.2016

    • Author(s)
      Desch&#234;nes M, Takatoh J, Kurnikova A, Moore JD, Demers M, Elbaz M, Furuta T, Wang F, Kleinfeld D.
    • Journal Title

      Neuron

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Cortico-cortical projection to the primary somatosensory cortex working for trigeminal sensory processing.2019

    • Author(s)
      Takahiro Furuta, Ken-ichi Shibata, Aya Takenaka, Atsushi Yoshida
    • Organizer
      第124回日本解剖学会全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cortico-thalamic reciprocal circuit working for trigeminal sensory processing.2019

    • Author(s)
      Takahiro Furuta
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Projection patterns of corticofugal neurons associated with vibrissa movement2018

    • Author(s)
      Takahiro Furuta, Ken-ichi Shibata, Takuma Tanaka, Hiroyuki Hioki
    • Organizer
      第123回日本解剖学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脊髄へ投射する大脳皮質運動野ニューロンの皮質内における軸索形態2017

    • Author(s)
      古田貴寛、金子武嗣
    • Organizer
      第122回日本解剖学会総会全国学術集会
    • Place of Presentation
      長崎大学
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Rhythmic Motor Pattern Control2017

    • Author(s)
      Miki Kaneshige, Ken-Ichi Shibata, Jun Matsubayashi, Akira Mitani, Takahiro Furuta
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Efficient Gene Delivery into Neuronal Cells using Adeno-Associated Virus Vector Equipped with the Tet-Off System2017

    • Author(s)
      Hiroyuki Hioki, Jaerin Sohn, Megumu Takahashi, Shinichiro Okamoto, Yoko Ishida, Takahiro Furuta
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Morphology of axonal arborizations of single layer III neurons in the rat presubiculum2017

    • Author(s)
      Yoshiko Honda, Takahiro Furuta, Takeshi Kaneko
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Morphologies of dendrites and local axons derived from single corticospinal neurons2017

    • Author(s)
      Takahiro Furuta, Takeshi Kaneko
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Spatiotemporal dynamics of sensory processing in the rat whisker tactile system.2015

    • Author(s)
      9.D HIRAI, KI SHIBATA, KC NAKAMURA, T TANAKA, H HIOKI, T KANEKO, T FURUTA.
    • Organizer
      Neuroscience 2015 Society for Neuroscience
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Architecture of whisker movement related neurons in rat primary motor cortex.2015

    • Author(s)
      柴田憲一、古田貴寛、田中琢真、平井大地、金子武嗣
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・神戸国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Book] Analysis of synaptic connections at the electron microscopic level using viral vectors. In: Receptor and Ion Channel Detection in the Brain: methods and protocols2016

    • Author(s)
      Furata T, Okamoto-Furuta K, Hioki H.
    • Total Pages
      9
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Remarks] Vibrissal mechanoreceptors in Scholarpedia

    • URL

      http://www.scholarpedia.org/article/Vibrissal_mechanoreceptors

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report

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Published: 2015-04-16   Modified: 2022-09-26  

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