|Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|Outline of Final Research Achievements
We have engaged in the multidisciplinary analysis on the regulatory mechanisms underlying adult hippocampal neurogenesis using mice. Main findings can be summarized as follows: (1) Administration of a plant-derived estrogen daidzein promoted the production of new granule cells in the dorsal hippocampus of middle-aged female mice. (2) Digestion of chondroitin sulfate proteoglycan (CSPG) in the dentate gyrus impaired the adult hippocampal neurogenesis and cognitive memory in adult male mice. Enriched environment (EE) increased the expression of CSPG in the dentate gyrus, and CSPG was required for the promotion of production of new granule cells by EE. (3) Administration of lactobacillus acidophilus promoted the production of new granule cells in dorsal hippocampus of middle-aged male mice, but not in young adult mice.