| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The investigators previously found microglia is aberrantly activated in the brain of schizophrenic patients by positron emission tomography. In the present study the investigators aim at exploring the neuropathology underlying microglial activation in the brain in the early stage of onset of schizophrenia, and development of in vivo MRI system to visualize behavior of microglia. Here, based on the observation that processing of fractalkine in the adjacent neuronal axon triggers microglial activation via its membranous CRXCR3 receptor, the pathophysiology of the activation of metabolic enzyme of neuronal fractalkine was explored and also MRI switching molecular probe to visualize the enzymatic activity was developed.
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