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Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology

Research Project

Project/Area Number 15H04275
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionOsaka University (2018)
Kyoto University (2015-2017)

Principal Investigator

HIKIDA Takatoshi  大阪大学, 蛋白質研究所, 教授 (70421378)

Research Collaborator MACPHERSON Tom  
MORITA Makiko  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords大脳基底核 / 報酬学習 / 忌避学習 / ドーパミン / 神経回路 / 精神疾患 / 海馬 / ドーパミン受容体 / 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 / 行動柔軟性 / 場所細胞
Outline of Final Research Achievements

We have analyzed the basal ganglia network mechanisms in cognitive learning. We found the pathway-specific intracellular signaling in aversive learning. Furthermore, we revealed the involvement of the indirect pathways and dopamine D2L receptors in flexibility of reward learning. Next, we examined reward place learning of mutant DISC1 transgenic mice as a mouse model of mental disorders. We have found the impairment in reward place learning of mutant DISC1 transgenic mice with social isolation stress. Reward-related neural activity was disappeared in hippocampal CA1 place cells of mutant DISC1 mice.

Academic Significance and Societal Importance of the Research Achievements

多くの精神神経疾患には認知行動障害が基礎症状として存在するが、その神経基盤は解明されていない。本研究では、認知学習における大脳基底核神経回路機構を解析し、報酬・忌避学習の神経基盤を明らかにした。また、精神疾患モデルマウスの報酬学習異常とその神経基盤を見出した。これらの研究成果は、精神神経疾患の病態を神経回路という新しい視点から解明するもので、新しい治療法開発につながることが期待できる。

Report

(4 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (80 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (21 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 17 results,  Open Access: 16 results,  Acknowledgement Compliant: 7 results) Presentation (52 results) (of which Int'l Joint Research: 15 results,  Invited: 19 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ジョンズ・ホプキンス大学/イリノイ大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] トロント大学(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] マックスプランク研究所(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ジョンズ・ホプキンス大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics2017

    • Author(s)
      Tomoda Toshifumi、Hikida Takatoshi、Sakurai Takeshi
    • Journal Title

      Neurotherapeutics

      Volume: 14 Issue: 3 Pages: 623-629

    • DOI

      10.1007/s13311-017-0556-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] In vivo calcium imaging from dentate granule cells with wide-field fluorescence microscopy2017

    • Author(s)
      Hayashi Yuichiro、Yawata Satoshi、Funabiki Kazuo、Hikida Takatoshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 7 Pages: e0180452-e0180452

    • DOI

      10.1371/journal.pone.0180452

    • NAID

      120006539578

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior2017

    • Author(s)
      Miyajima M、Zhang B、Sugiura Y、Sonomura K、Guerrini MM、Tsutsui Y、Maruya M、Vogelzang A、Chamoto K、Honda K、Hikida T、Ito S、Qin H、Sanuki R、Suzuki K、Furukawa T、Ishihama Y、Matsuda F、Suematsu M、Honjo T、Fagarasan S
    • Journal Title

      Nature Immunology

      Volume: 18 Issue: 12 Pages: 1342-1352

    • DOI

      10.1038/ni.3867

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 認知学習における大脳基底核神経回路機構2017

    • Author(s)
      疋田貴俊、森田真規子、Macpherson Tom
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 37 Pages: 35-38

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経回路から精神疾患病態へ2017

    • Author(s)
      疋田貴俊
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 28 Pages: 132-134

    • NAID

      130007630327

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Ulk1 protects against ethanol-induced neuronal stress and cognitive deficits in object discrimination.2017

    • Author(s)
      Akiko Sumitomo, Keisho Ueta, Sayaka Mauchi, Kazuko Hirai, Kouta Horike, Takatoshi Hikida, Takeshi Sakurai, Akira Sawa, Toshifumi Tomoda
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 54-61

    • DOI

      10.1016/j.neures.2016.12.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of leptin in conditioned place preference to high-fat diet in leptin-deficient ob/ob mice.2017

    • Author(s)
      Shimizu Y, Son C, Aotani D, Nomura H, Hikida T, Hosoda K, Nakao K
    • Journal Title

      Neuroscience Letters

      Volume: 640 Pages: 60-63

    • DOI

      10.1016/j.neulet.2017.01.033

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation.2017

    • Author(s)
      Kitanishi,T., Ito,H.T., Hayashi,Y., Shinohara,Y., Mizuseki,K., Hikida,T.
    • Journal Title

      J. Physiol Sci.

      Volume: 67 Issue: 2 Pages: 247-258

    • DOI

      10.1007/s12576-016-0502-z

    • NAID

      40021113908

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T.
    • Journal Title

      Learning and Memory

      Volume: 23 Issue: 7 Pages: 359-364

    • DOI

      10.1101/lm.042507.116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place discrimination task in the IntelliCage.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
    • Journal Title

      Molecular Neuropsychiatry

      Volume: 2 Issue: 3 Pages: 124-132

    • DOI

      10.1159/000447970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1.2016

    • Author(s)
      Jaaro-Peled H, Altimus C, LeGates T, Cash-Padgett T, Zoubovsky S, Hikida T, Ishizuka K, Hattar S, Mongrain V, Sawa A
    • Journal Title

      Neuroscience Research

      Volume: 112 Pages: 63-69

    • DOI

      10.1016/j.neures.2016.06.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system.2016

    • Author(s)
      Aotani D, Son C, Shimizu Y, Nomura H, Hikida T, Kusakabe T, Tanaka T, Miyazawa T, Hosoda K, Nakao K
    • Journal Title

      Neuroscience Letters

      Volume: 633 Pages: 141-145

    • DOI

      10.1016/j.neulet.2016.09.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Endocytosis following dopamine D2 receptor activation is critical for neuronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons.2016

    • Author(s)
      Shioda N*, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
    • Journal Title

      Molecular Psychiatry

      Volume: 印刷中 Issue: 8 Pages: 1205-1222

    • DOI

      10.1038/mp.2016.200

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural mechanism of the nucleus accumbens circuit in reward and aversive learning.2016

    • Author(s)
      Hikida T, Morita M, Macpherson T
    • Journal Title

      Neurosci. Res.

      Volume: - Pages: 1-5

    • DOI

      10.1016/j.neures.2016.01.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 大脳基底核神経回路からみた薬物依存症の病態2016

    • Author(s)
      疋田貴俊
    • Journal Title

      精神科臨床Legato

      Volume: 2 Pages: 190-192

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Impaired hippocampal activity at the goal zone on the place preference task in a DISC mouse model2016

    • Author(s)
      Hayashi Y, Sawa A, Hikida T
    • Journal Title

      Neurosci. Res.

      Volume: VOL. 106 Pages: 70-73

    • DOI

      10.1016/j.neures.2015.10.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning2015

    • Author(s)
      Yamaguchi T, Goto A, Nakahara I, Yawata S, Hikida T, Matsuda M, Funabiki K, Nakanishi S
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: VOL. 112 Issue: 36 Pages: 11383-11388

    • DOI

      10.1073/pnas.1514731112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nuclear-translocated glyceraldehyde-3-phosphate dehydrogenase promotes poly(ADP-ribose) polymerase-1 activation during oxidative/nitrosative stress in stroke.2015

    • Author(s)
      Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma Y, Inui T, Kamiya A, Sawa A, Takeuchi T
    • Journal Title

      J. Biol. Chem.

      Volume: VOL. 290 Issue: 23 Pages: 14493-14503

    • DOI

      10.1074/jbc.m114.635607

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments2015

    • Author(s)
      Takeshi Sakurai, Nao J. Gamo, Takatoshi Hikida, Sun-Hong Kim, Toshiya Murai, Toshifumi Tomoda, Akira Sawa
    • Journal Title

      Progress in Neurobiology

      Volume: 134 Pages: 178-201

    • DOI

      10.1016/j.pneurobio.2015.09.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pathway-specific Modulation of Nuclus Accumbens in Reward and Aversive Learning Behaviors and Drug Addiction via Selective Transmitter Receptors.2015

    • Author(s)
      疋田貴俊
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 47-48

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 大脳基底核神経回路機構における直接路と間接路の機能分離2015

    • Author(s)
      森田真規子、疋田貴俊
    • Journal Title

      日本神経精神薬理学雑誌

      Volume: 35 Pages: 107-111

    • Related Report
      2015 Annual Research Report
  • [Presentation] 柔軟な行動のための大脳基底核神経回路の恒常性維持機構とその破綻2017

    • Author(s)
      疋田貴俊
    • Organizer
      第90回日本薬理学会シンポジウム
    • Place of Presentation
      長崎新聞文化ホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 神経細胞におけるp62発現上昇およびオートファジー減弱によるGABA受容体表面定時の低下と精神疾患の病態生理2017

    • Author(s)
      住友明子、植田啓公頁、堀家康太、北岡志保、古屋敷智之、疋田貴俊、櫻井武、澤明、友田利文、成宮周
    • Organizer
      第90回日本薬理学会シンポジウム
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 認知学習におけるドーパミンD2L受容体の役割解析2017

    • Author(s)
      疋田貴俊
    • Organizer
      新潟脳神経研究会
    • Place of Presentation
      新潟大学脳研究所(新潟県・新潟市)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて2017

    • Author(s)
      疋田貴俊
    • Organizer
      大阪大学蛋白質研究所 蛋白研未来コロキウム
    • Place of Presentation
      大阪大学蛋白質研究所(大阪府・吹田市)
    • Year and Date
      2017-01-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 統合失調症病態における淡蒼球の役割解析2017

    • Author(s)
      疋田貴俊
    • Organizer
      第9回脳表現型の分子メカニズム研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高次脳機能の回路機構と精神疾患の分子病態の解明に向けて2017

    • Author(s)
      疋田貴俊
    • Organizer
      第78回統合失調症研究勉強会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] D2L receptor-expressing striatal neurons control visual discrimination learning in a touchscreen operant system.2017

    • Author(s)
      Hikida T, Morita M, Macpherson T
    • Organizer
      26th Annual Meeting of the International Behavioral Neuroscience Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Basal ganglia circuit mechanisms for flexible behavior2017

    • Author(s)
      Hikida T
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Dual neural circuits in reward and aversive learning2017

    • Author(s)
      Hikida T
    • Organizer
      第27回神経回路学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 認知学習と精神疾患における神経回路機構2017

    • Author(s)
      疋田貴俊
    • Organizer
      第47回日本神経精神薬理学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構2017

    • Author(s)
      疋田貴俊
    • Organizer
      第39回日本生物学的精神医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 情動行動における大脳基底核神経回路機構とその破綻2017

    • Author(s)
      疋田貴俊
    • Organizer
      平成29年度生理学研究所研究会「先天的と後天的なメカニズムの融合による情動・行動の理解と制御」
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neuronal circuit mechanisms in reward and aversive behavior.2017

    • Author(s)
      Hikida T
    • Organizer
      National Tsing Hua University-Osaka University International Student Symposium 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Basal ganglia network mechanisms in cognitive learning2017

    • Author(s)
      Hikida T
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Nucleus accumbens D1 receptor expressing neurons control sutoshaping behavior.2017

    • Author(s)
      Hikida T
    • Organizer
      56th Annual Meeting of the American College of Neuropsychopharmacology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways.2016

    • Author(s)
      Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
    • Organizer
      55th Annual Meeting of the American College of Neuropsychopharmacology
    • Place of Presentation
      フロリダ(アメリカ)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Expression changes in prefrontal cortex after neurotransmission blocking of the nucleus accumbens pathways.2016

    • Author(s)
      Hikida T, Yao S, Fukakusa A, Morita M, Kimura H, Hirai K, Ando T, Toyoshiba H, Sawa A
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Learning deficits involving nucleus accumbens D2-receptor expressing neurons in a DISC1 mouse model.2016

    • Author(s)
      Morita M, Macpherson T, Sawa A, Hikida T
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel therapeutic target for stroke by inhibition of GAPDH aggregation.2016

    • Author(s)
      Itakura M, Kubo T, Kaneshige A, Azuma Y, Hikida T, Takeuchi T, Nakajima H.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens neurons is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Tom Macpherson, Makiko Morita, Yanyan Wang, Toshikuni Sasaoka, Akira Sawa, Takatoshi Hikida
    • Organizer
      日本生理学会第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学医学研究科(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 変異型DISC1トランスジェニックマウスは場所選好試験において海馬CA1場所細胞の報酬関連活動の低下を示す2016

    • Author(s)
      疋田貴俊、林勇一郎、澤明
    • Organizer
      日本生理学会第109回近畿生理学談話会
    • Place of Presentation
      大阪市立大学医学研究科(大阪府・大阪市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドパミンによる大脳基底核神経回路の制御機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      平成28年度日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 意思決定と薬物依存における大脳基底核神経回路機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経回路から精神疾患病態へ2016

    • Author(s)
      疋田貴俊
    • Organizer
      第38回日本生物学的精神医学会、第59回日本神経化学会大会合同年会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 認知学習における大脳基底核神経回路機構2016

    • Author(s)
      疋田貴俊
    • Organizer
      第61回 脳の医学・生物学研究会
    • Place of Presentation
      名古屋大学医学部(愛知県・名古屋市)
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 側坐核直接路の活性化はリスク志向な行動選択に関与する2016

    • Author(s)
      王 天、溝口博之、犬束 歩、片平健太郎、疋田貴俊、山中章弘、山田清文
    • Organizer
      第18回応用薬理シンポジウム
    • Place of Presentation
      名古屋大学医学部(愛知県・名古屋市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioral flexibility in a place learning task.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dopamine D2L receptor is required for cognitive learning in a visual discrimination task.2016

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T.
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nucleus accumbens dopamine D2-receptor expressing neurons control behavioural flexibility in a place learning task in the IntelliCage.2016

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      10th FENS Forum of Neuroscience
    • Place of Presentation
      コペンハーゲン(デンマーク)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] DISC1変異マウス海馬における報酬関連活動の減弱2016

    • Author(s)
      林勇一郎、澤明、疋田貴俊
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Subregion-specific striatal pathway control of Pavlovian associative learning.2016

    • Author(s)
      Macpherson T, Morita M, Sawa A, Hikida T
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] ドーパミンD2L受容体は視覚弁別課題の認知学習に重要である2016

    • Author(s)
      森田 真規子、ワン ヤンヤン、笹岡 俊邦、澤 明、疋田 貴俊
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 精神疾患におけるドーパミン神経ネットワーク機構2016

    • Author(s)
      疋田 貴俊
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Activity in dopamine D2-receptor-expressing nucleus accumbens is necessary for behavioral flexibility in an IntelliCage place discrimination task.2016

    • Author(s)
      Hikida T
    • Organizer
      International Symposium “Wiring and Functional Principles of Neural Circuits”
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 報酬と忌避の意志決定の機構解析2015

    • Author(s)
      疋田 貴俊
    • Organizer
      平成27年度包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      一橋大学一橋講堂(東京都)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nucleus accumbens plays a role in arm choice behavior in the rodent gambling test.2015

    • Author(s)
      Mizoguchi H, Inutsuka A, Hikida T, Yamanaka A, Yamada K.
    • Organizer
      平成27年度包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      一橋大学一橋講堂(東京都)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Social isolated DISC1 mutant mice displayed high sensitivity to chronic cocaine exposure and rolipram treatment2015

    • Author(s)
      Hikida T, Morita M, Niwa M, Kuroiwa A, Macpherson T, Itou T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A
    • Organizer
      54th Annual Meeting of the American College of Neuropsychopharmacology
    • Place of Presentation
      フロリダ(アメリカ合衆国)
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ドーパミンD2L受容体は視覚弁別学習に関与する。2015

    • Author(s)
      森田 真規子、笹岡 俊邦、Yanyan Wang,澤 明、疋田 貴俊
    • Organizer
      BMB2015, 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Dopamine D2L receptors influence visual discrimination task on the touchscreen system.2015

    • Author(s)
      Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      International Symposium on Prediction and Decision Making 2015
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] D2L receptors of the striatal indirect pathway control behavioral flexibility in a place learning task.2015

    • Author(s)
      Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A, Hikida T
    • Organizer
      International Symposium on Prediction and Decision Making 2015
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impaired hippocampal reward-related activity in the DISC1 mutant mice.2015

    • Author(s)
      Hayashi Y, Sawa A, Hikida T
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 薬物依存形成における大脳基底核神経回路機構2015

    • Author(s)
      疋田 貴俊
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 快・不快情報に基づく行動選択における大脳基底核神経回路機構2015

    • Author(s)
      疋田 貴俊
    • Organizer
      平成27年度生理学研究所研究会 情動の多次元的理解に基づく行動原理の探求
    • Place of Presentation
      生理学研究所(愛知県・岡崎市)
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Cocaine-induced behavioral sensitization is regulated by PDE4 in social stressed DISC1 mutant mice.2015

    • Author(s)
      Hikida T, Morita M, Macpherson T, Itou T, Niwa M, Kuroiwa M, Sawa A, Nishi A.
    • Organizer
      第37回日本生物学的精神医学会・第45回日本神経精神薬理学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of PDEs in alteration of dopamine signaling after isolation stress in DISC1 mutant mice.2015

    • Author(s)
      Kuroiwa M, Shuto T, Sotogaku N, Morita M, Sawa A, Hikida T, Nishi A.
    • Organizer
      第37回日本生物学的精神医学会・第45回日本神経精神薬理学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cocaine-induced behavioral sensitization is regulated by PDE4 in social stressed DISC1 mutant mice2015

    • Author(s)
      Morita M, Macpherson T, Itou T, Niwa M, Kuroiwa M, Nishi A, Sawa A, Hikida T
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] FEZ1 regulates autophagy and promotes against neuropsychiatric manifestation.2015

    • Author(s)
      Sumitomo A, Saka A, Mauchi S, Hikida T, Sakurai T, Nakayama KI, Sawa A, Tomoda T
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of PDEs in response of cAMP/PKA signaling to isolation stress in DISC1 mutant mice.2015

    • Author(s)
      Kuroiwa M, Shuto T, Sotogaku N, Morita M, Sawa A, Hikida T, Nishi A.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] The direct striatal pathway is necessary for the attribution of incentive salience to reward-predictive cues.2015

    • Author(s)
      Macpherson T, Morita M, Sawa A, Hikida T.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impaired hippocampal reward-related activity in the DISC1 mutant mice.2015

    • Author(s)
      Hayashi Y, Sawa A, Hikida T.
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法2018

    • Inventor(s)
      岡正啓、疋田貴俊、他5名
    • Industrial Property Rights Holder
      岡正啓、疋田貴俊、他5名
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 精神疾患モデル動物およびその製造方法2017

    • Inventor(s)
      岡 正啓、(4名省略)、疋田 貴俊、森田 真規子
    • Industrial Property Rights Holder
      医薬基盤・健康・栄養研究所、京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-026027
    • Filing Date
      2017-02-15
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-09-26  

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