| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
We have analyzed the basal ganglia network mechanisms in cognitive learning. We found the pathway-specific intracellular signaling in aversive learning. Furthermore, we revealed the involvement of the indirect pathways and dopamine D2L receptors in flexibility of reward learning. Next, we examined reward place learning of mutant DISC1 transgenic mice as a mouse model of mental disorders. We have found the impairment in reward place learning of mutant DISC1 transgenic mice with social isolation stress. Reward-related neural activity was disappeared in hippocampal CA1 place cells of mutant DISC1 mice.
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