Basal ganglia circuit mechanisms in cognitive behavior and neuropsychiatric pathology
| Project/Area Number |
15H04275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University (2018)
Kyoto University (2015-2017) |
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Principal Investigator |
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| Research Collaborator |
MACPHERSON Tom
MORITA Makiko
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 大脳基底核 / 報酬学習 / 忌避学習 / ドーパミン / 神経回路 / 精神疾患 / 海馬 / ドーパミン受容体 / 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 / 行動柔軟性 / 場所細胞 |
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| Outline of Final Research Achievements |
We have analyzed the basal ganglia network mechanisms in cognitive learning. We found the pathway-specific intracellular signaling in aversive learning. Furthermore, we revealed the involvement of the indirect pathways and dopamine D2L receptors in flexibility of reward learning. Next, we examined reward place learning of mutant DISC1 transgenic mice as a mouse model of mental disorders. We have found the impairment in reward place learning of mutant DISC1 transgenic mice with social isolation stress. Reward-related neural activity was disappeared in hippocampal CA1 place cells of mutant DISC1 mice.
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| Academic Significance and Societal Importance of the Research Achievements |
多くの精神神経疾患には認知行動障害が基礎症状として存在するが、その神経基盤は解明されていない。本研究では、認知学習における大脳基底核神経回路機構を解析し、報酬・忌避学習の神経基盤を明らかにした。また、精神疾患モデルマウスの報酬学習異常とその神経基盤を見出した。これらの研究成果は、精神神経疾患の病態を神経回路という新しい視点から解明するもので、新しい治療法開発につながることが期待できる。
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation.2017
Author(s)
Kitanishi,T., Ito,H.T., Hayashi,Y., Shinohara,Y., Mizuseki,K., Hikida,T.
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Journal Title
J. Physiol Sci.
Volume: 67
Issue: 2
Pages: 247-258
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Nuclear-translocated glyceraldehyde-3-phosphate dehydrogenase promotes poly(ADP-ribose) polymerase-1 activation during oxidative/nitrosative stress in stroke.2015
Author(s)
Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma Y, Inui T, Kamiya A, Sawa A, Takeuchi T
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Journal Title
J. Biol. Chem.
Volume: VOL. 290
Issue: 23
Pages: 14493-14503
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Social isolated DISC1 mutant mice displayed high sensitivity to chronic cocaine exposure and rolipram treatment2015
Author(s)
Hikida T, Morita M, Niwa M, Kuroiwa A, Macpherson T, Itou T, Shuto T, Sotogaku N, Niwa M, Sawa A, Nishi A
Organizer
54th Annual Meeting of the American College of Neuropsychopharmacology
Place of Presentation
フロリダ（アメリカ合衆国）
Year and Date
2015-12-06
Related Report
Int'l Joint Research
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[Presentation] ドーパミンD2L受容体は視覚弁別学習に関与する。2015
Author(s)
森田 真規子、笹岡 俊邦、Yanyan Wang,澤 明、疋田 貴俊
Organizer
BMB2015, 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
Place of Presentation
神戸国際会議場（兵庫県・神戸市）
Year and Date
2015-12-01
Related Report
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