Mechanism of PKD activation for monoamine release
| Project/Area Number |
15H04276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya City University (2017)
Kyushu University (2015-2016) |
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Principal Investigator |
Shirane Michiko 名古屋市立大学, 大学院薬学研究科, 教授 (90398082)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | モノアミン / 細胞内情報伝達 / 神経科学 / PKD / プロトルーディン |
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| Outline of Final Research Achievements |
The question in this project is whether PKD is associated with monoamine release at the TGN. For this aim, we investigateｄ the regulatory mechanism of PKD activation. We focused on the association of PKD on membrane curvature, and it is suggested that PKD regulates membrane dynamics at the TGN through protrudin binding protein PDZD8 and TMEM55B.
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Report
(4 results)
Research Products
(5 results)
