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Mechanism of PKD activation for monoamine release

Research Project

Project/Area Number 15H04276
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNagoya City University (2017)
Kyushu University (2015-2016)

Principal Investigator

Shirane Michiko  名古屋市立大学, 大学院薬学研究科, 教授 (90398082)

Co-Investigator(Renkei-kenkyūsha) NAKAYAMA Keiichi  九州大学, 生体防御医学研究所, 教授 (80291508)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywordsモノアミン / 細胞内情報伝達 / 神経科学 / PKD / プロトルーディン
Outline of Final Research Achievements

The question in this project is whether PKD is associated with monoamine release at the TGN. For this aim, we investigated the regulatory mechanism of PKD activation. We focused on the association of PKD on membrane curvature, and it is suggested that PKD regulates membrane dynamics at the TGN through protrudin binding protein PDZD8 and TMEM55B.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (5 results)

All 2017 2015

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth.2017

    • Author(s)
      Ohnishi, T., Shirane, M., and Nakayama, K. I.
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 709-719

    • DOI

      10.1038/srep41130

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 膜コンタクト部位によるエンドソーム輸送の制御機構2015

    • Author(s)
      白根道子
    • Journal Title

      細胞工学

      Volume: 34 Pages: 1080-1085

    • NAID

      40020628753

    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経の病気の謎に迫る2017

    • Author(s)
      白根 道子
    • Organizer
      名古屋市立大学×名古屋市科学館 サイエンスパートナーシップイベント
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経疾患のなぞ ~狂牛病やアルツハイマー病はどのように発症する?~2017

    • Author(s)
      白根 道子
    • Organizer
      市民公開講座 第5回 脳の健康のために知る
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 小胞体の膜構造制御と遺伝性痙性対麻痺の病態2015

    • Author(s)
      白根道子、橋本 寛、中山 敬一
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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