| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
Towards the goal of characterizing the dynamic interaction between astrocytes and synapses and identifying the underlying molecular mechanisms, we first constructed astrocyte-specific probes and validated promoters for astrocyte-specific expression. We then estabished virus production and stereotactic injection system to enable astrocyte-specific molecular manipulation in acute hippocampal slice preparations. Furthermore, we explored the role for gap junctions, which had previously been implicated in affecting asrtocyte-synapse structural contacts, and identified a functional role for the connexins, the gap junction proteins, in controlling synaptic strength and plasticity.
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