| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
To unravel molecular and circuit mechanisms underlying attention and impulse control, we analyzed a series of conditional mutants for NMDA receptor gene. The mutant mouse lime lacking NMDA receptors in neurons of intralaminar thalamic nucleus showed remarkable abnormalities in cognitive functions including attention, impulse control, and working memory, and REM sleep. We also provided evidence that NMDA receptors in hippocampal CA1 neurons have a role in determining subjective values of rewords, and thus effect on behaviors in delay discounting task. Using transgenic mouse lines that express calcium sensor proteins in a selective cell-type specific manner, we demonstrated that the medial and parietal association cortex has a crucial role in integrating information by multisensory stimulation.
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