| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Src tyrosine kinase is the first-identified onco-protein, and plays a crucial role in promoting tumor malignancy, such as invasive and metastatic ability, when its function is upregulated during tumor progression. However, molecular mechanism underlying the dysregulation of Src expression/activity and its actual roles in tumor progression remain elusive. To address these issues, we analyzed the regulatory mechanism of SRC gene expression and the functions of scaffold proteins that activate Src. Based on these analyses, we proposed new models of the molecular mechanisms for Src-mediated tumor progression.
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