Grant-in-Aid for Scientific Research (B)
To clarify the mechanism of germline mutation occurrence that causes familial tumor, we analyzed Mth1/Ogg1/Mutyh triple KO (TOY-KO) mice, which feature a mutator phenotype. At first we screened the causative gene of familial tumor observed in the TOY-KO mouse pedigree by whole exome sequence analysis, and determined a candidate gene. We established and cryopreserved a new TOY-KO mouse line. In addition to the TOY-KO mouse, we established TO-, OY-, TY-, T-, O- and Y-KO mice in the same genetic back ground. Using new TOY-KO mice, spontaneous tumorigenesis experiment has performed (continues). In these mice, we observed accumulation of mutations in nuclear genome, but not in the mitochondrial genome.
J Dermatol Sci.
Pathol Int. 2017 Nov;67(11):564-574.
AIMS Molecular Science
Free Radic Biol Med
Attribution of KAKENHI