Analysis of molecular mechanism underlying de novo colorectal tumorigenesis pathway

• Project/Area Number: 15H04299
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Sapporo Medical University
• Principal Investigator: Suzuki Hiromu 札幌医科大学, 医学部, 教授 (20381254)
• Co-Investigator(Kenkyū-buntansha): 山本 英一郎 札幌医科大学, 医学部, 講師 (60567915) ; 甲斐 正広 札幌医科大学, 医学部, 講師 (80260777) ; 丸山 玲緒 札幌医科大学, 医学部, 研究員 (60607985)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: 大腸がん / エピゲノム / DNAメチル化 / 遺伝子変異 / 大腸腺腫 / 鋸歯状病変 / 診断マーカー / 癌 / ゲノム / 遺伝子 / 発現制御 / 表面型大腸腫瘍 / 細胞・組織

Outline of Final Research Achievements

Recent advances in the cancer genome study revealed molecular alterations in colorectal cancer (CRC). However, mechanisms underlying the colorectal tumorigenesis in pathways other than the conventional adenoma-carcinoma sequence are not fully understood. To address this issue, we focused on early colorectal lesions with superficial or laterally spreading morphologies and those in the serrated neoplastic pathway. Through performing genetic and epigenetic analysis in a large number of primary colorectal tumors, we identified NTSR1, DKGK, SMOC1 and ZNF582-AS1 as novel CRC-related genes. We found that methylation of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors while methylation of SMOC1 is associated with the development of traditional serrated adenomas. Surface microstructures of early colorectal tumors are associated with genetic and epigenetic alterations, and are associated with the malignant potential.

Research Products

• [Journal Article] Subtypes of the Type II Pit Pattern Reflect Distinct Molecular Subclasses in the Serrated Neoplastic Pathway. (2018)
  • Author(s): Aoki H, Yamamoto E, Yamano HO, Sugai T, Kimura T, Tanaka Y, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Nakaoka M, Yoshida Y, Harada T, Sudo G, Eizuka M, Yorozu A, Kitajima H, Niinuma T, Kai M, Nojima M, Suzuki H, Nakase H.
  • Journal Title: Dig Dis Sci. Volume: 15 Issue: 7 Pages: 1920-1928
  • DOI: 10.1007/s10620-018-5016-5
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic silencing of SMOC1 in traditional serrated adenoma and colorectal cancer. (2017)
  • Author(s): Aoki H, Yamamoto E, Takasawa A, Niinuma T, Yamano HO, Harada T, Matsushita HO, Yoshikawa K, Takagi R, Harada E, Tanaka Y, Yoshida Y, Aoyama T, Eizuka M, Yorozu A, Kitajima H, Kai M, Sawada N, Sugai T, Nakase H, Suzuki H.
  • Journal Title: Oncotarget. Volume: 9 Issue: 4 Pages: 4707-4721
  • DOI: 10.18632/oncotarget.23523
  • Peer Reviewed / Open Access
• [Journal Article] Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors. (2017)
  • Author(s): Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shimomura Y, Nakase H, Suzuki H
  • Journal Title: Oncology Letters Volume: 14 Pages: 5703-5710
  • DOI: 10.3892/ol.2017.6911
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer. (2017)
  • Author(s): Kai M, Yamamoto E, Sato A, Yamano HO, Niinuma T, Kitajima H, Harada T, Aoki H, Maruyama R, Toyota M, Hatahira T, Nakase H, Sugai T, Yamashita T, Toyota M, Suzuki H.
  • Journal Title: Mol Carcinog Volume: - Issue: 7 Pages: 1743-1752
  • DOI: 10.1002/mc.22631
  • Peer Reviewed / Open Access
• [Journal Article] Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. (2017)
  • Author(s): Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y
  • Journal Title: Cancer Science Volume: 108 Issue: 12 Pages: 2413-2421
  • DOI: 10.1111/cas.13420
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. (2017)
  • Author(s): Sugai T, Yoshida M, Eizuka M, Uesugii N, Habano W, Otsuka K, Sasaki A, Yamamoto E, Matsumoto T, Suzuki H.
  • Journal Title: Clin Epigenetics. Volume: 55 Issue: 1 Pages: 55-55
  • DOI: 10.1186/s13148-017-0352-4
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic and Molecular Characterization of Colorectal Sessile Serrated Adenoma/polyps with Cytological Dysplasia. (2017)
  • Author(s): Tanaka Y, Yamano HO, Yamamoto E, Matushita HO, Aoki H, Yoshikawa K, Takagi R, Harada E, Nakaoka M, Yoshida Y, Eizuka M, Sugai T, Suzuki H, Nakase H.
  • Journal Title: Gastrointest Endosc. Volume: 86 Issue: 6 Pages: 1131-1138
  • DOI: 10.1016/j.gie.2017.05.006
  • Peer Reviewed / Open Access
• [Journal Article] Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays. (2017)
  • Author(s): Eizuka M, Sugai T, Habano W, Uesugi N, Takahashi Y, Kawasaki K, Yamamoto E, Suzuki H, Matsumoto T.
  • Journal Title: J Gastroenterol Volume: - Issue: 11 Pages: 1158-1168
  • DOI: 10.1007/s00535-017-1317-2
  • Peer Reviewed / Open Access
• [Journal Article] Molecular subtypes of colorectal cancers determined by PCR-based analysis. (2017)
  • Author(s): Sugai T, Eizuka M, Takahashi Y, Fukagawa T, Habano W, Yamamoto E, Akasaka R, Otuska K, Matsumoto T, Suzuki H.
  • Journal Title: Cancer Sci Volume: 108(3) Issue: 3 Pages: 427-434
  • DOI: 10.1111/cas.13164
  • Peer Reviewed / Open Access
• [Journal Article] Genetic differences stratified by PCR-based microsatellite analysis in gastric intramucosal neoplasia. (2017)
  • Author(s): Sugai T, Sugimoto R, Habano W, Endoh M, Eizuka M, Tsuchida K, Yamamoto E, Kawasaki K, Yanai S, Matsumoto T, Suzuki H.
  • Journal Title: Gastric Cancer. Volume: 20 Issue: 2 Pages: 286-296
  • DOI: 10.1007/s10120-016-0616-2
  • NAID: 40021129465
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of DNA copy number alterations in early and advanced gastric cancers. (2017)
  • Author(s): Arakawa N, Sugai T, Habano W, Eizuka M, Sugimoto R, Akasaka R, Toya Y, Yamamoto E, Koeda K, Sasaki A, Matsumoto T, Suzuki H.
  • Journal Title: Mol Carcinog. Volume: 56 Issue: 2 Pages: 527-537
  • DOI: 10.1002/mc.22514
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of molecular alterations in laterally spreading tumors of the colorectum. (2017)
  • Author(s): Sugai T, Habano W, Takagi R, Yamano H, Eizuka M, Arakawa N, Takahashi Y, Yamamoto E, Kawasaki K, Yanai S, Ishida K, Suzuki H, Matsumoto T.
  • Journal Title: J Gastroenterol Volume: 52 Issue: 6 Pages: 715-723
  • DOI: 10.1007/s00535-016-1269-y
  • NAID: 110006550042
  • Peer Reviewed / Open Access
• [Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells. (2016)
  • Author(s): Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
  • Journal Title: PLoS One Volume: 11 Issue: 12 Pages: e0168281-e0168281
  • DOI: 10.1371/journal.pone.0168281
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer. (2016)
  • Author(s): Takahashi Y, Sugai T, Habano W, Ishida K, Eizuka M, Otsuka K, Sasaki A, Matsumoto T, Morikawa T, Unno M, Suzuki H.
  • Journal Title: Int J Cancer Volume: 139 Issue: 11 Pages: 2493-2501
  • DOI: 10.1002/ijc.30377
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic activation of LY6K predicts the presence of metastasis and poor prognosis in breast carcinoma. (2016)
  • Author(s): Kong HK, Park SJ, Kim YS, Kim KM, Lee HW, Kang HG, Woo YM, Park EY, Ko JY, Suzuki H, Chun KH, Song E, Jang KY, Park JH.
  • Journal Title: Oncotarget Volume: 7 Issue: 34 Pages: 55677-55689
  • DOI: 10.18632/oncotarget.10972
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer. (2016)
  • Author(s): Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano HO, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 26699-26699
  • DOI: 10.1038/srep26699
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of epigenetic alterations in early colorectal lesions containing BRAF mutations. (2016)
  • Author(s): Sawada T, Yamamoto E, Yamano HO, Nojima M, Harada T, Maruyama R, Ashida M, Aoki H, Matsushita HO, Yoshikawa K, Harada E, Tanaka Y, Wakita S, Niinuma T, Kai M, Eizuka M, Sugai T, Suzuki H.
  • Journal Title: Oncotarget Volume: 7 Issue: 23 Pages: 35106-35118
  • DOI: 10.18632/oncotarget.9044
  • NAID: 120006534714
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical prognostic value of DNA methylation in hepatoblastoma: Four novel tumor suppressor candidates (2016)
  • Author(s): Honda S, Minato M, Suzuki H, Fujiyoshi M, Miyagi H, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A
  • Journal Title: Cancer Science Volume: in press Issue: 6 Pages: 812-819
  • DOI: 10.1111/cas.12928
  • NAID: 120005828475
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype (2016)
  • Author(s): Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
  • Journal Title: Int J Cancer Volume: 1 Issue: 7 Pages: 1689-97
  • DOI: 10.1002/ijc.29916
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors (2015)
  • Author(s): Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
  • Journal Title: Oncotarget Volume: 6 Issue: 30 Pages: 29975-90
  • DOI: 10.18632/oncotarget.5034
  • NAID: 130005161526
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors. (2015)
  • Author(s): Isosaka M, Niinuma T, Nojima M, Kai M, Yamamoto E, Maruyama R, Nobuoka T, Nishida T, Kanda T, Taguchi T, Hasegawa T, Tokino T, Hirata K, Suzuki H, Shinomura Y
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0133754-e0133754
  • DOI: 10.1371/journal.pone.0133754
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. (2015)
  • Author(s): 5.Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ohka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y
  • Journal Title: Cancer Prev Res (Phila) Volume: 10 Issue: 8 Pages: 702-11
  • DOI: 10.1158/1940-6207.capr-14-0306
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer. (2015)
  • Author(s): Su Y, Subedee A, Bloushtain-Qimron N, Savova V, Krzystanek M, Li L, Marusyk A, Tabassum DP, Zak A, Flacker MJ, Li M, Lin JJ, Sukumar S, Suzuki H, Long H, Szallasi Z, Gimelbrant A, Maruyama R, Polyak K.
  • Journal Title: Cell Rep Volume: 11 Issue: 10 Pages: 1549-1563
  • DOI: 10.1016/j.celrep.2015.05.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Molecular analysis of isolated tumor glands from endometrial endometrioid adenocarcinomas. (2015)
  • Author(s): Suga Y, Sugai T, Uesugi N, Kawasaki T, Fukagawa T, Yamamoto E, Ishida K, Suzuki H, Sugiyama T.
  • Journal Title: Pathol Int Volume: 65 Issue: 5 Pages: 240-249
  • DOI: 10.1111/pin.12274
  • Peer Reviewed / Open Access
• [Journal Article] Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis. (2015)
  • Author(s): Mitsuhashi K, Nosho K, Sukawa Y, Matsunaga Y, Ito M, Kurihara H, Kanno S, Igarashi H, Naito T, Adachi Y, Tachibana M, Tanuma T, Maguchi H, Shinohara T, Hasegawa T, Imamura M, Kimura Y, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
  • Journal Title: Oncotarget Volume: 6 Pages: 7209-7220
  • Peer Reviewed / Open Access
• [Journal Article] Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway. (2015)
  • Author(s): Ito M, Kanno S, Nosho K, Sukawa Y, Mitsuhashi K, Kurihara H, Igarashi H, Takahashi T, Tachibana M, Takahashi H, Yoshii S, Takenouchi T, Hasegawa T, Okita K, Hirata K, Maruyama R, Suzuki H, Imai K, Yamamoto H, Shinomura Y.
  • Journal Title: Int J Cancer Volume: 137 Issue: 6 Pages: 1258-1268
  • DOI: 10.1002/ijc.29488
  • Peer Reviewed
• [Journal Article] Contextual niche signals towards colorectal tumor progression by mesenchymal stem cell in the mouse xenograft model. (2015)
  • Author(s): Nakagaki S, Arimura Y, Nagaishi K, Isshiki H, Nasuno M, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y.
  • Journal Title: Journal of Gastoroenterology Volume: 50 Issue: 9 Pages: 962-74
  • DOI: 10.1007/s00535-015-1049-0
  • Peer Reviewed
• [Presentation] 大腸がんにおけるDiacylglycerol kinase γのエピジェネティックな不活化 (2017)
  • Author(s): 甲斐正広、山本英一郎、佐藤亜紀子、山野泰穂、新沼猛、北嶋洋志、原田拓、青木敬則、仲瀬裕志、菅井有、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 新規大腸がん線維芽細胞関連遺伝子の同定 (2017)
  • Author(s): 沼田有斗、萬顕、山本英一郎、新沼猛、北嶋洋志、甲斐正広、青木敬則、若杉英樹、時野隆至、仲瀬裕志、菅井有、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 大腸がんにおける腫瘍血管内皮関連遺伝子の同定 (2017)
  • Author(s): 萬顕、山本英一郎、沼田有斗、新沼猛、北嶋洋志、甲斐正広、青木敬則、若杉英樹、時野隆至、仲瀬裕志、菅井有、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] SMOC1のエピジェネティックなサイレンシングは大腸鋸歯状腺腫の発育進展に関与する (2017)
  • Author(s): 青木敬則、山本英一郎、高澤啓、新沼猛、山野泰穂、原田拓、萬顕、北嶋洋志、甲斐正広、澤田典均、仲瀬裕志、菅井有、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 大腸腺腫の表面構造が反映する腫瘍内不均一性 (2017)
  • Author(s): 山本英一郎、山野泰穂、青木敬則、新沼猛、甲斐正広、佐々木泰史、時野隆至、菅井有、仲瀬裕志、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 消化管間質腫瘍においてエピジェネティックに制御される長鎖non-coding RNAの探索 (2017)
  • Author(s): 新沼猛、北嶋洋志、山本英一郎、甲斐正広、仲瀬裕志、時野隆至、今井浩三、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 慢性胃炎および胃癌に関する長鎖noncoding RNAの同定と機能解析 (2017)
  • Author(s): 北嶋洋志、丸山玲緒、山本英一郎、新沼猛、青木敬則、甲斐正広、時野隆至、今井浩三、仲瀬裕志、鈴木拓
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] CpGアイランドメチル化形質：発生機序と臨床的意義 (2016)
  • Author(s): 鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 大腸鋸歯状腺腫の進展に関わるDNAメチル化異常の同定 (2016)
  • Author(s): 青木敬則、山本英一郎、山野泰穂、萬顕、石黒一也、原田拓、新沼猛、甲斐正広、足立靖、遠藤高夫、菅井有、鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 大腸がんにおけるdiacylglycerol kinase zeta遺伝子バリアントのエピジェネティックな制御 (2016)
  • Author(s): 甲斐正広、新沼猛、北嶋洋志、丸山玲緒、山本英一郎、鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 慢性胃炎および胃癌に関連する長鎖noncoding RNAの同定 (2016)
  • Author(s): 北嶋洋志、丸山玲緒、山本英一郎、新沼猛、青木敬則、原田拓、甲斐正広、仲瀬裕志、時野隆至、鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 大腸癌における腫瘍血管内皮関連遺伝子の同定 (2016)
  • Author(s): 萬顕、山本英一郎、津矢田明泰、沼田有斗、甲斐正広、新沼猛、北嶋洋志、青木敬則、若杉英樹、時野隆至、仲瀬裕志、菅井有、鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 消化管間質腫瘍の再発に関連するmicroRNAの解析 (2016)
  • Author(s): 新沼猛、若杉英樹、山本英一郎、甲斐正広、鈴木拓
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] 鋸歯状腺腫においてメチル化する遺伝子の同定と臨床病理・分子生物学的検討 (2015)
  • Author(s): 青木敬則、山本英一郎、山野泰穂、檜森亮吾、新沼 猛、甲斐正広、丸山玲緒、足立 靖、遠藤高夫、菅井 有、鈴木 拓
  • Organizer: 第26回日本消化器癌発生学会総会
  • Place of Presentation: 米子全日空ホテル（米子市）
  • Year and Date: 2015-11-19
• [Presentation] がん細胞のDNAメチル化維持におけるUHRF1の関与 (2015)
  • Author(s): 鈴木 拓、新沼 猛、甲斐正広、丸山玲緒、山本英一郎、今井浩三
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 正常大腸粘膜におけるヒストンH3K27トリメチル化はCIMP大腸がんの発生に関与する (2015)
  • Author(s): 山本英一郎、丸山玲緒、山野泰穂、青木敬則、檜森亮吾、萬 顕、新沼 猛、甲斐正広、菅井 有、今井浩三、篠村恭久、鈴木 拓
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] BRAF遺伝子変異を伴う大腸前癌病変と背景粘膜のメチル化解析 (2015)
  • Author(s): 澤田 武、山本英一郎、山野泰穂、野島正寛、原田 拓、青木敬則、新沼 猛、丸山玲緒、甲斐正広、片岡洋望、菅井 有、鈴木 拓、城 卓志
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 大腸癌における腫瘍血管内皮特異的遺伝子の新規同定 (2015)
  • Author(s): 萬 顕、山本英一郎、丸山玲緒、津矢田明泰、甲斐正広、新沼 猛、檜森亮吾、廣橋良彦、西館敏彦、古畑智久、平田公一、菅井 有、鈴木 拓
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 大腸癌においてDNAメチル化により抑制されている長鎖非コードRNAの網羅的探索 (2015)
  • Author(s): 石黒一也、粂川昂平、丸山玲緒、山本英一郎、津矢田明泰、進藤哲哉、新沼 猛、甲斐正広、山野泰穂、菅井 有、時野隆至、篠村恭久、鈴木 拓
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] NTSR1遺伝子のメチル化は大腸腫瘍の側方進展および低浸潤性と相関する (2015)
  • Author(s): 鈴木 拓、山本英一郎、神前正幸、甲斐正広、新沼 猛、山野泰穂、野島正寛、篠村恭久、今井浩三、丸山玲緒
  • Organizer: 第35回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-07
• [Presentation] 大腸がんにおけるnon-coding RNA遺伝子のエピゲノム解析と臨床への応用 (2015)
  • Author(s): 丸山玲緒、原田 拓、粂川昂平、山本英一郎、山野泰穂、新沼 猛、野島正寛、篠村恭久、今井浩三、鈴木 拓
  • Organizer: 第35回日本分子腫瘍マーカー研究会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-07