Identification and analysis of new androgen responsive regulatory genes for development and cancer.
| Project/Area Number |
15H04300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Yamada Gen 和歌山県立医科大学, 先端医学研究所, 教授 (80174712)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | アンドロゲン / 男性ホルモン / bZipファミリー / 癌関連繊維芽細胞 / MafB / 生殖器間葉細胞 / 外生殖器 / 前立腺 / 癌繊維芽細胞 / 前立腺癌 / エンハンサー / アンドロゲンレセプター / 発生制御 / 発現制御 / 雄性化 / ホルモン |
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| Outline of Final Research Achievements |
The current study suggests that the Mafb 3' untranslated region (UTR) is an essential region for its regulation by androgen. We identified 2 functional androgen response elements (AREs) in Mafb 3UTR.
Androgen receptor is bound to such AREs in 3UTR during urethral masculinization. By using such identified UTR-enhancer, we revealed new candidate upstream gene for MafB regulation. Our ongoing study suggests such new transcription factor-AR interaction is essential for regulating MafB enhancer. CAF cells have been also suggested as playing essential role for prostate cancer. The current study gives insight for the regulation of bZip family gene function not only in embryonic mesenchyme cells but also for cancer associated fibroblast (CAF) cells.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Functional distinctions associated with the diversity of sex steroid hormone receptors ESR and AR.2018
Author(s)
Yukiko Ogino, Saki Tohyama, Satomi Kohno, Kenji Toyota, Gen Yamada, Ryohei Yatsu, Tohru Kobayashi, Norihisa Tatarazako, Tomomi Sato, Hajime Matsubara, Anke Lange, Charles R. Tyler, Yoshinao Katsu, Taisen Iguchi, Shinichi Miyagawa.
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Journal Title
Journal of Steroid Biochemistry and Molecular Biology
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Establishment of estrogen receptor 1 (ESR1)-knockout medaka; ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes.2017
Author(s)
Tohyama S, Ogino Y, Lange A, Myosho T, Kobayashi T, Hirano Y, Yamada G, Sato T, Tatarazako N, Tyler CR, Iguchi T, Miyagawa S.
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Journal Title
Dev Growth Diff
Volume: 59
Issue: 6
Pages: 552-561
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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