| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
We tried to develop novel designs for bispecific antibodies which can be converted into functional format around cancer tissues. First, we integrated a recognition sequence of cancer specific protease into bispecific antibodies to convert into flexible format with high therapeutic effects around cancer. However, decreases in the activity were observed. Then, we integrated the same recognition sequence into a hinge region of Fc-fused bispecific antibody to convert into the small format with high tumor penetration ability from the format with long in vivo half-life. This design successfully produced functional small bispecific antibody by protease digestion.
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