Elucidation of the chemoresistance in pancreatic cancer and development of its tumor stroma targeting ADCs
| Project/Area Number |
15H04316
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Yasunaga Masahiro 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (80450576)
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| Research Collaborator |
Matsumura Yasuhiro 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (90209619)
Manabe Shino 独立行政法人理化学研究所, 伊藤細胞制御化学, 専任研究員 (60300901)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 抗体 / ADC / 膵臓がん / がん間質 / 間質バリア / DDS / 分子イメージング / ドラッグイメージング / 癌 / 間質 / ドラッグデリバリー |
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| Outline of Final Research Achievements |
(1) Pancreatic cancer model mice with a strong desmoplastic reaction similar to human pancreatic cancer was prepared. (2) We succeeded in developing a new drug imaging method by combining robot-controlled ESI (Electrospray ionization) method and an LC-MS apparatus. It has become possible to observe drug delivery within the tumor tissue with high sensitivity. (3) a) Anti-fibroblast / b) stellate and parietal cell / c) blood-vessel / d) blood and lymphoid vessel antibodies showed good tumor-stroma targeting within the tumor tissues. Regarding antibody-drug conjugates (ADCs), they were newly-produced and therapeutic experiments were conducted in the model of (1). A strong antitumor effect was observed in the order of a)b)c)d).(4) Anti-tissue factor/fibrin ADCs also showed therapeutic effect in the same mouse model.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Antitumor effect of antitissue factor antibody-MMAE conjugate in human pancreatic tumor xenografts.2015
Author(s)
Koga Y, Manabe S, Aihara Y, Sato R, Tsumura R, Iwafuji H, Furuya F, Fuchigami H, Fujiwara Y, Hisada Y, Yamamoto Y, Yasunaga M, Matsumura Y.
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Journal Title
Int J Cancer.
Volume: 137
Issue: 6
Pages: 1457-1466
DOI
Related Report
Peer Reviewed
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[Presentation] Development of ADC utilizing molecular imaging2016
Author(s)
Masahhiro Yasunaga, Shino Manabe, Atushi Tsuji, Masaru Furuta, Koretsugu Ogata, Yuki Fujiwara, Yoshikazu Koga, Yasuhiro Matsumura
Organizer
Antibody Engineering & Therapeutics
Place of Presentation
San Diego, USA
Year and Date
2016-12-13
Related Report
Int'l Joint Research
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