| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
|
|---|
| Outline of Final Research Achievements |
We have found that force-sensitive transcriptional co-activator MKL2 shuttles from cytoplasm into nucleus in very rapid response to shear stress, which completes within 10 minutes. We also found that this response is mediated by purinergic receptor activation and subsequent Ca signaling. To explore further the roles played by MKL2, we successfully made Mkl2 KO mice, which shows interesting phenotypes in circulatory system, such as heart and vasculatures. These phenotypes can be explained by a loss of response to mechanical stress in circulation. In addition, we found other unexpected interesting phenotypes in eyes and energy metabolism. We are preparing a manuscript, in which all data found in this project will be included.
|
