| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
In this grant period we investigated control of meiotic prophase chromosome dynamics by phosphorylation in C. elegans. Our starting point was the phosphatase PPH-4.1, which we had previously identified as a critical regulator of at least 4 critical chromosome dynamics events. We identified SYP-1, a member of the synaptonemal complex, as an important phosphoprotein in meiosis. SYP-1 phosphorylation is required for correct chromosome segregation, acting to specify the region in which chromosome cohesion will be lost in the first meiotic division. Additionally, our data shows that SYP-1 phosphorylation is required to recruit Polo-like kinase to the chromosome central region, as well as to promote the correct distribution of genetic crossovers on chromosomes.
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