| Budget Amount *help |
¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Meiosis is a special type of cell division that generates haploid gametes from diploid cells. In this study, we performed functional analysis of RNA-binding proteins that regulate meiosis in fission yeast. In fission yeast, a YTH-type RNA-binding protein, Mmi1, suppresses expression of meiotic genes in mitotically growing cells by inducing selective RNA degradation and facultative heterochromatin formation. We demonstrated that Mmi1 prevents the untimely expression of meiotic genes by tethering their mRNAs to nuclear foci. Mmi1 also regulates the termination of transcription of its target genes.
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