| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
The widely accepted models for circadian clocks are based on transcriptional-translational negative feedback loops composed of circadian clock genes. However, some important aspects, such as how the periods are adjusted around 24 h and how the phase of the rhythms are determined, are not fully incorporated into these models. On the other hand, there are several examples of protein posttranscriptional modification rhythms independent of the feedback loops, though their exact roles in the circadian clock systems are still unknown. In this study we tried to elucidate these points by proteomic and chemical biology approach. We obtained compounds that affect period and phase and the potential candidates of their target proteins. We also set up the system to study posttranslational modification rhythms including phosphorylation. By these bidirectional approaches, we are now trying to understand the whole circadian clock systems.
|
