| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
In this study, we examined the hypothesis that raft-associated glycolipids and GPI-anchored receptors (GARs) form homodimers via specific interactions, and work as a unit for downstream signal transduction.
We found that a variety of glycolipids and GARs formed homodimers via specific interactions, which can be generalized. We also found that the homodimers of glycolipids and GARs were stabilized by lipid interactions. Furthermore, our results suggest that these homodimers work as a unit for inducing downstream signaling events or for regulating activity of membrane receptors.
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