| Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In cancer cells, the expression of glycolytic enzymes is regulated by stress-responsive transcriptional factors (e.g., HIF-Ia and c-Myc). Recent studies demonstrated that post-translational modifications of metabolic enzymes also regulate metabolic reprogramming. Our previous study showed that arginine methylation of glycolytic enzymes is spatial regulated in the nucleus. In this study, we clarified the mechanism of nuclear-specific arginine methylation of enzymes. Furthermore, we found that auto-methylation of PRMT1, which is a responsible methyltransferase for glycolytic enzymes influenced the nuclear translocation of PRMT1, resulted in nuclear-specific methylation of glycolytic enzymes.
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