| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
We investigated the mechanisms of chromosome alignment on the spindle and faithful chromosome segregation. In the process of chromosome alignment, kinetochores on chromosomes first attach to the lateral surface of spindle microtubules (lateral attachment), and then attach to the end of microtubules (end-on attachment). We searched for molecules involved in lateral attachment, and found the involvement of the motor proteins, dynein and CENP-E. We also found that lateral attachment and end-on attachment cooperatively contribute to chromosome alignment and faithful chromosome segregation (Sci Rep, 2018). Furthermore, we revealed that a mitotic kinase Plk1 plays a role in the spindle assemble checkpoint, which is important for the maintenance of chromosomal stability (Sci Rep, 2017).
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