Maintenance of chromosomal stability by efficient chromosome alignment
| Project/Area Number |
15H04368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Tanaka Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Masanori 東北大学, 加齢医学研究所, 教育研究支援者 (80645010)
YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110)
KANNO Shin-ichiro 東北大学, 加齢医学研究所, 講師 (10400417)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Keywords | 癌 / 細胞・組織 / 染色体 |
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| Outline of Final Research Achievements |
We investigated the mechanisms of chromosome alignment on the spindle and faithful chromosome segregation. In the process of chromosome alignment, kinetochores on chromosomes first attach to the lateral surface of spindle microtubules (lateral attachment), and then attach to the end of microtubules (end-on attachment). We searched for molecules involved in lateral attachment, and found the involvement of the motor proteins, dynein and CENP-E. We also found that lateral attachment and end-on attachment cooperatively contribute to chromosome alignment and faithful chromosome segregation (Sci Rep, 2018). Furthermore, we revealed that a mitotic kinase Plk1 plays a role in the spindle assemble checkpoint, which is important for the maintenance of chromosomal stability (Sci Rep, 2017).
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.2018
Author(s)
Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K.
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Journal Title
Biochemical Journal
Volume: 475
Issue: 5
Pages: 981-1002
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP)2017
Author(s)
Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno S, Tanaka K, Hashimoto H.
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Journal Title
Journal of Biological Chemistry
Volume: 292
Issue: 43
Pages: 17658-17667
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Activation of Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholestrol Gallstones.2017
Author(s)
Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H
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Journal Title
Gastroenterology
Volume: 印刷中
Issue: 6
Pages: 30012-4
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] De Novo Truncating Mutations in the kinetochore-microtubules attachment gene CHAMP1 Cause Syndromic Intellectual Disability.2016
Author(s)
Isidor, B, Kury, S, Rosenfeld, J, A, Besnard, T, (28 authors), Iemura, K, Ikeda, M, Tanaka, K, Bezieau, S.
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Journal Title
Hum Mutat
Volume: 37
Issue: 4
Pages: 354-358
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.2016
Author(s)
Hasanpourghadi, M, Karthikeyan, C, Pandurangan, A, K, Looi, C, Y, Trivedi, P, Kobayashi, K, Tanaka, K, Wong W, F, Mustafa, M, R.
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Journal Title
J Exp Clin Cancer Res
Volume: 35
Issue: 1
Pages: 38-38
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo2015
Author(s)
M. Ohira, Y. Iwasaki, C. Tanaka, M. Kuroki, N. Matsuo, T. Kitamura, M. Yukuhiro, H. Morimoto, N. Pang, B. Liu, T. Kiyono, M. Amemiya, K. Tanaka, K. Yoshida, N. Sugimoto, T. Ohshima, M. Fujita
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Journal Title
Biochimica et Biophysica Acta (BBA) - General Subjects
Volume: 1850
Issue: 9
Pages: 1676-1684
DOI
Related Report
Peer Reviewed
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[Presentation] 染色体不安定性とがん2016
Author(s)
田中耕三
Organizer
第75回日本癌学会学術総会
Place of Presentation
パシフィコ横浜（横浜市・神奈川県）
Year and Date
2016-10-06
Related Report
Invited
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[Presentation] 染色体不安定性と発がん2015
Author(s)
田中耕三
Organizer
第9回日本エピジェネティクス研究会
Place of Presentation
学術総合センター（千代田区・東京都）
Year and Date
2015-05-25
Related Report
Invited
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