• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Maintenance of chromosomal stability by efficient chromosome alignment

Research Project

Project/Area Number 15H04368
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionTohoku University

Principal Investigator

Tanaka Kozo  東北大学, 加齢医学研究所, 教授 (00304452)

Co-Investigator(Renkei-kenkyūsha) IKEDA Masanori  東北大学, 加齢医学研究所, 教育研究支援者 (80645010)
YASUI Akira  東北大学, 加齢医学研究所, 教授 (60191110)
KANNO Shin-ichiro  東北大学, 加齢医学研究所, 講師 (10400417)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords癌 / 細胞・組織 / 染色体
Outline of Final Research Achievements

We investigated the mechanisms of chromosome alignment on the spindle and faithful chromosome segregation. In the process of chromosome alignment, kinetochores on chromosomes first attach to the lateral surface of spindle microtubules (lateral attachment), and then attach to the end of microtubules (end-on attachment). We searched for molecules involved in lateral attachment, and found the involvement of the motor proteins, dynein and CENP-E. We also found that lateral attachment and end-on attachment cooperatively contribute to chromosome alignment and faithful chromosome segregation (Sci Rep, 2018). Furthermore, we revealed that a mitotic kinase Plk1 plays a role in the spindle assemble checkpoint, which is important for the maintenance of chromosomal stability (Sci Rep, 2017).

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (89 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (11 results) Journal Article (18 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (58 results) (of which Int'l Joint Research: 18 results,  Invited: 8 results) Remarks (2 results)

  • [Int'l Joint Research] CHU Nantes/CHU Angers/CHRU Brest(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine/SUNY Upstate Medical University(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] NHS Greater Glasgow and Clyde/University Hospital of Wales/Newcastle upon Tyne Hospitals(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] CHU Nantes/CHU Angers/CHRU Brest(フランス)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine/SUNY Upstate Medical University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] NHS Greater Glasgow and Clyde/University Hospital of Wales/Newcastle upon Tyne Hospitals(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] CHU Nantes/INSERM/CHU Angers(フランス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Baylor College of Medicine/SUNY Upstate Medical University(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] NHS Greater Glasgow and Clyde/Newcastle upon Tyne Hospitals(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Malaya(マレーシア)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Rajiv Gandhi Technical University(インド)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Lateral attachment of kinetochores to microtubles is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment2018

    • Author(s)
      Itoh G, Ikeda M, Iemura K, Amin MA, Kuriyama S, Tanaka M, Mizuno N, Osakada H, Haraguchi T, Tanaka K
    • Journal Title

      Sci Rep

      Volume: 8(1) Issue: 1 Pages: 3888-3888

    • DOI

      10.1038/s41598-018-22164-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.2018

    • Author(s)
      Li J, Shima H, Nishizawa H, Ikeda M, Brydun A, Matsumoto M, Kato H, Saiki Y, Liu L, Watanabe-Matsui M, Iemura K, Tanaka K, Shiraki T, Igarashi K.
    • Journal Title

      Biochemical Journal

      Volume: 475 Issue: 5 Pages: 981-1002

    • DOI

      10.1042/bcj20170520

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanism for efficient chromosome alignment in mitosis2017

    • Author(s)
      家村顕自, 田中耕三
    • Journal Title

      生化学

      Volume: 89 Issue: 1 Pages: 102-105

    • DOI

      10.14952/SEIKAGAKU.2017.890102

    • NAID

      40021119817

    • ISSN
      0037-1017
    • Year and Date
      2017-02-25
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP)2017

    • Author(s)
      Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno S, Tanaka K, Hashimoto H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 43 Pages: 17658-17667

    • DOI

      10.1074/jbc.m117.804237

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis2017

    • Author(s)
      Ikeda Masanori、Tanaka Kozo
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 8794-8794

    • DOI

      10.1038/s41598-017-09114-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 染色体不安定性とがん2017

    • Author(s)
      田中耕三
    • Journal Title

      血液内科

      Volume: 75 Pages: 117-122

    • NAID

      40021268813

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones2017

    • Author(s)
      Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, Ikeda M, Murakami K, Munakata Y, Shirai Y, Kodama S, Sugisawa T, Chiba Y, Kondo Y, Kaneko K, Uno K, Sawada S, Imai J, Nakamura Y, Yamaguchi H, Tanaka K, Sasano H, Mano N, Ueno Y, Shimosegawa T, Katagiri H
    • Journal Title

      Gastroenterology

      Volume: 152 Issue: 6 Pages: 1521

    • DOI

      10.1053/j.gastro.2017.01.001

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chromosomal instability: a common feature and a therapeutic target of cancer.2016

    • Author(s)
      Tanaka, K., and Hirota, T.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1866 Issue: 1 Pages: 64-75

    • DOI

      10.1016/j.bbcan.2016.06.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] <b>Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin </b><b>KIF4A </b>2016

    • Author(s)
      Takahashi, M., Tanaka, K., Wakai, T., Hirota, T.
    • Journal Title

      Biomedical Research

      Volume: 37 Issue: 2 Pages: 161-165

    • DOI

      10.2220/biomedres.37.161

    • NAID

      130005147428

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] De Novo Truncating Mutations in the kinetochore-microtubules attachment gene CHAMP1 Cause Syndromic Intellectual Disability.2016

    • Author(s)
      Isidor, B, Kury, S, Rosenfeld, J, A, Besnard, T, (28 authors), Iemura, K, Ikeda, M, Tanaka, K, Bezieau, S.
    • Journal Title

      Hum Mutat

      Volume: 37 Issue: 4 Pages: 354-358

    • DOI

      10.1002/humu.22952

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 1枚の写真館 「側面結合」との出会い.2016

    • Author(s)
      田中耕三.
    • Journal Title

      細胞工学

      Volume: 35 Pages: 95-95

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell.2016

    • Author(s)
      Hasanpourghadi, M, Karthikeyan, C, Pandurangan, A, K, Looi, C, Y, Trivedi, P, Kobayashi, K, Tanaka, K, Wong W, F, Mustafa, M, R.
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 35 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s13046-016-0332-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phosphoproteomic analysis of human mitotic chromosomes identified a chromokinesin KIF4A.2016

    • Author(s)
      Takahashi, M, Tanaka, K, Wakai, T, Hirota, T.
    • Journal Title

      Biomed Res

      Volume: 37

    • NAID

      130005147428

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo2015

    • Author(s)
      M. Ohira, Y. Iwasaki, C. Tanaka, M. Kuroki, N. Matsuo, T. Kitamura, M. Yukuhiro, H. Morimoto, N. Pang, B. Liu, T. Kiyono, M. Amemiya, K. Tanaka, K. Yoshida, N. Sugimoto, T. Ohshima, M. Fujita
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - General Subjects

      Volume: 1850 Issue: 9 Pages: 1676-1684

    • DOI

      10.1016/j.bbagen.2015.04.013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CLIP-170 tethers kinetochores to microtubule plus ends against poleward force by dynein for stable kinetochore-microtubule attachment.2015

    • Author(s)
      Amin, M, A, Kobayashi, K, and Tanaka, K.
    • Journal Title

      FEBS Lett

      Volume: 589 Issue: 19PartB Pages: 2739-2746

    • DOI

      10.1016/j.febslet.2015.07.036

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mitosis.2015

    • Author(s)
      Tanaka, K.
    • Journal Title

      eLS

      Volume: - Pages: 1-11

    • DOI

      10.1002/9780470015902.a0001356.pub2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 染色体安定性制御と疾患 総論 染色体不安定性の病態生理.2015

    • Author(s)
      田中耕三.
    • Journal Title

      細胞

      Volume: 47 Pages: 212-214

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 治療標的としてのAuroraキナーゼによる動原体制御.2015

    • Author(s)
      田中耕三.
    • Journal Title

      血液内科

      Volume: 71 Pages: 712-717

    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス脳における染色体整列因子CAMPの発現局在の解析2018

    • Author(s)
      永井正義, 家村顕自, 吉川貴子, 大隅典子, 田中耕三
    • Organizer
      第11回リトリート大学院生研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス胎児脳における染色体整列因子CAMPの発現部位の同定2018

    • Author(s)
      永井正義, 家村顕自, 吉川貴子, 大隅典子, 田中耕三
    • Organizer
      第7回東北脳科学ウィンタースクール
    • Related Report
      2017 Annual Research Report
  • [Presentation] Centrosomal kinase Aurora A is required for the robust system of equal chromosome segregation2017

    • Author(s)
      Kenji Iemura and Kozo Tanaka
    • Organizer
      The 2017 Japan-NIH joint Symposium
    • Place of Presentation
      Seiryo Auditorium(Sendai・Miyagi, Japan)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulatory mechanism of spindle assembly checkpoint by mitotic kinase Plk1 and its role in mitotic progression2017

    • Author(s)
      Masanori Ikeda and Kozo Tanaka
    • Organizer
      The 2017 Japan-NIH joint Symposium
    • Place of Presentation
      Seiryo Auditorium(Sendai・Miyagi, Japan)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Defect in efficient chromosome alignment cause chromosomal instability2017

    • Author(s)
      Kinue Kuniyasu, Kenji Iemura, Kozo Tanaka
    • Organizer
      The 2017 Japan-NIH joint Symposium
    • Place of Presentation
      Seiryo Auditorium(Sendai・Miyagi, Japan)
    • Year and Date
      2017-02-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impact of chromosome dynamics on the fidelity of chromosome transmission2017

    • Author(s)
      Kozo Tanaka
    • Organizer
      国立遺伝学研究所バイオロジカルシンポジウム
    • Place of Presentation
      国立遺伝学研究所(三島市・静岡県)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 中心体キナーゼAurora Aは染色体均等分配の堅牢性の維持に寄与する2017

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第34回染色体ワークショップ・第15回核ダイナミクス研究会
    • Place of Presentation
      かずさアカデミアホール(木更津市・千葉県)
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Plk1によるM期進行を司る新規分子基盤の解明2017

    • Author(s)
      池田真教、 田中耕三
    • Organizer
      第34回染色体ワークショップ・第15回核ダイナミクス研究会
    • Place of Presentation
      かずさアカデミアホール(木更津市・千葉県)
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] 染色体整列の効率性の低下が染色体不安定性を引き起こす2017

    • Author(s)
      國安絹枝,家村顕自, 田中耕三
    • Organizer
      第34回 染色体ワークショップ 第15回 核ダイナミクス研究会
    • Place of Presentation
      かずさアカデミアホール(木更津市・千葉県)
    • Year and Date
      2017-01-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Alterations in chromosome dynamics impair the fidelity of chromosome transmission2017

    • Author(s)
      Kozo Tanaka
    • Organizer
      International Workshop on Quantitative Biology 2017
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromosomal instability in aging and cancer2017

    • Author(s)
      Kozo Tanaka
    • Organizer
      Tohoku Forum for Creativity Thematic Program 2017 Aging Science: from Molecules to Society Topic1 “Aging Biology”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞周期制御因子CAMPの天然変性タンパク質としての制御基盤の解明2017

    • Author(s)
      池田真教, 三上嘉子, 藤田拡樹, 古寺哲幸, 安藤敏夫, 田中耕三
    • Organizer
      日本生化学会東北支部第83回例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chromosome oscillation ensures faithful chromosome segregation through Hec1 phosphorylation by Aurora A2017

    • Author(s)
      Kenji Imeura, Kozo Tanaka
    • Organizer
      EMBO Workshop “Dynamic Kinetochore”
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aurora Aは正常細胞における染色体均等分配システムの堅牢性を保証する2017

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 紡錘体チェックポイント活性の維持に関わる分子基盤の解明2017

    • Author(s)
      池田真教, 田中耕三
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 染色体整列の時空間的な遅延が染色体不安定性を引き起こす2017

    • Author(s)
      國安絹枝, 家村顕自, 田中耕三
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 染色体整列分子CAMPによるDNA損傷修復を介したゲノム安定性維持の分子基盤2017

    • Author(s)
      藤田拡樹, 池田真教, 三上嘉子, 田中耕三
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経細胞の発生及び分化における染色体整列因子CAMPの機能解析2017

    • Author(s)
      永井正義, 家村顕自, 池田真教, 田中耕三
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Functional analysis of CAMP(CHAMP1), a heterochromatin-associated protein related to intellectual disability2017

    • Author(s)
      Masanori Ikeda, Hiroki Fujita, Noriyuki Kodera, Toshio Ando, Kenji Iemura, Masayoshi Nagai, Kozo Tanaka
    • Organizer
      The 2nd meeting on SMC proteins
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 天然変性タンパク質CAMPを含む複合体の機能解析2017

    • Author(s)
      田中耕三, 池田真教, 藤田拡樹, 古寺哲幸, 安藤敏夫, 家村顕自, 永井正義
    • Organizer
      第17回日本蛋白質科学会年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新規分子CAMPを含むヘテロクロマチン結合複合体によるゲノム安定性維持機構2017

    • Author(s)
      田中耕三
    • Organizer
      新学術領域クロマチン動構造第5回班会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高速AFMによるヘテロクロマチン結合複合体の動的制御の解明2017

    • Author(s)
      池田真教, 三上嘉子, 藤田拡樹, 古寺哲幸, 安藤敏夫, 田中耕三
    • Organizer
      第2回クロマチン動構造ワークショップ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規分子CAMPによる分裂期細胞死制御機構2017

    • Author(s)
      田中耕三
    • Organizer
      第26回日本Cell Death学会学術集
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 神経細胞の発生及び分化における染色体整列因子CAMPの機能解析2017

    • Author(s)
      永井正義, 家村顕自, 池田真教, 田中耕三
    • Organizer
      第57回生命科学夏の学校
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高速AFMによる天然変性タンパク質CAMPの構造動態観察2017

    • Author(s)
      成田知恕, 池田真教, 田中耕三, 古寺哲幸
    • Organizer
      第55回日本生物物理学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel mechanism for maintenance of chromosomal stability2017

    • Author(s)
      Kenji Iemura, Kozo Tanaka
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス胎児脳における染色体整列因子CAMPの発現部位の同定2017

    • Author(s)
      永井正義, 家村顕自, 吉川貴子, 大隅典子, 田中耕三
    • Organizer
      2017年度生命科学系合同年次大会(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chromosomal instability in cancer and aging2017

    • Author(s)
      Kenji Iemura, Kinue Kuniyasu, Manuel Campos, Guan Chen, Kozo Tanaka
    • Organizer
      第12回研究所ネットワーク国際シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 染色体オシレーションと異常な結合の修正を記述する動原体-微小管結合の数学的モデル2017

    • Author(s)
      Manuel Campos, 家村顕自, 田中耕三
    • Organizer
      2017年度生命科学系合同年次大会(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス脳における染色体整列因子CAMPの発現解析2017

    • Author(s)
      永井正義, 家村顕自, 吉川貴子, 大隅典子, 田中耕三
    • Organizer
      第35回染色体ワークショップ・第16回核ダイナミクス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中心体キナーゼAurora Aは分裂期染色体動態に応答して動原体分子をリン酸化する2016

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 分裂期キナーゼPlk1による紡錘体チェックポイント制御機構とその機能的役割の解明2016

    • Author(s)
      池田真教、田中耕三
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Defect in efficient chromosome alignment cause chromosome instability2016

    • Author(s)
      Kinue Kuniyasu, Kenji Iemura, Kozo Tanaka
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2016

    • Author(s)
      國安絹枝,家村顕自,田中耕三
    • Organizer
      第3回 加齢研リトリート
    • Place of Presentation
      秋保リゾートホテルクレセント (仙台市・宮城県)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] Chromosomal instability caused by defective chromosome dynamics2016

    • Author(s)
      Kozo Tanaka
    • Organizer
      2016 International Conference of the Korean Society for Molecular and Cellular Biology
    • Place of Presentation
      COEX(ソウル・韓国)
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Defective chromosome dynamics as a cause of chromosomal instability in cancer2016

    • Author(s)
      田中耕三
    • Organizer
      International Conference of the Korean Society for Molecular and Cellular Biology 2016
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-10-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chromosomal instability caused by defective chromosome dynamics2016

    • Author(s)
      Kozo Tanaka
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 染色体不安定性とがん2016

    • Author(s)
      田中耕三
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市・神奈川県)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 効率的な染色体整列の異常による染色体不安定性の出現2016

    • Author(s)
      田中耕三
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市・愛知県)
    • Year and Date
      2016-10-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2016

    • Author(s)
      國安絹枝,家村顕自, 田中耕三
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス(仙台市・宮城県)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞分裂期進行における分裂期キナーゼPlk1の新規機能の解明2016

    • Author(s)
      池田真教, 田中耕三
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター/東北大学川内北キャンパス(仙台市・宮城県)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2016

    • Author(s)
      國安絹枝, 家村顕自, 田中耕三
    • Organizer
      第2回 研究所若手アンサンブルワークショップ
    • Place of Presentation
      東北大学金属材料研究所(仙台市・宮城県)
    • Year and Date
      2016-07-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中心体キナーゼAurora Aは分裂中期におけるキネトコア-微小管結合の修正に寄与する2016

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都テルサ(京都市・京都府)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中心体キナーゼAurora Aが触媒する分裂期中期における動原体分子のリン酸化の役割2016

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第82回日本生化学会東北支部例会
    • Place of Presentation
      弘前大学(弘前市・青森県)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] M期キナーゼPlk1による紡錘体チェックポイント制御機構の解明2016

    • Author(s)
      池田真教, 田中耕三
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会
    • Place of Presentation
      松島一の坊(松島町・宮城県)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2016

    • Author(s)
      國安絹枝, 家村顕自, 田中耕三
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会
    • Place of Presentation
      松島一の坊(松島町・宮城県)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 赤道面に整列した染色体でのキネトコア-微小管結合修正におけるAurora Aの役割2016

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第33回染色体ワークショップ・第14回核ダイナミクス研究会
    • Place of Presentation
      松島一の坊(松島町・宮城県)
    • Year and Date
      2016-01-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] ゲノム安定性を司る紡錘体チェックポイントの新規分子機構の解明2015

    • Author(s)
      池田真教, 田中耕三
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸市・兵庫)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2015

    • Author(s)
      國安絹枝, 家村顕自, 田中耕三
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(神戸市・兵庫)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 効率的な染色体整列の染色体安定性への関与2015

    • Author(s)
      小林絹枝、家村顕自、田中耕三
    • Organizer
      平成27年度がん若手研究者ワークショップ
    • Place of Presentation
      蓼科グランドホテル滝の湯(茅野市・長野県)
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of Kid and CENP-E on Efficient Chromosome Alignment2015

    • Author(s)
      Kenji Iemura, Kozo Tanaka
    • Organizer
      International Symposium on Chromatin Structure, Dynamics, and Function
    • Place of Presentation
      淡路夢舞台(淡路市・兵庫県)
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 紡錘体微小管と非コードDNA領域の相互作用による染色体の空間的制御2015

    • Author(s)
      田中耕三
    • Organizer
      新学術領域研究「ゲノムを支える非コードDNA領域の機能」第9回班会議
    • Place of Presentation
      淡路夢舞台(淡路市・兵庫県)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 効率的な染色体整列の異常による染色体不安定性の出現2015

    • Author(s)
      田中耕三
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋市・愛知県)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of Kid and CENP-E on efficient chromosome alignment2015

    • Author(s)
      Kenji Iemura, Kozo Tanaka
    • Organizer
      第10回研究所ネットワ-ク国際シンポジウム
    • Place of Presentation
      北海道大学医学部学友会館(札幌市・北海道)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 効率的な染色体整列におけるKid及びCENP-Eの機能解析2015

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(江戸川区・東京都)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 染色体不安定性と発がん2015

    • Author(s)
      田中耕三
    • Organizer
      第9回日本エピジェネティクス研究会
    • Place of Presentation
      学術総合センター(千代田区・東京都)
    • Year and Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 効率的な染色体整列におけるKid 及びCENP-E の役割2015

    • Author(s)
      家村顕自, 田中耕三
    • Organizer
      第81回日本生化学会東北支部例会
    • Place of Presentation
      東北大学片平さくらホール(仙台市・宮城県)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chromosomal instability: a road to cancer and aging2015

    • Author(s)
      田中耕三
    • Organizer
      Alfred Benzon Workshop
    • Place of Presentation
      デコペンハーゲン(デンマーク)
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 東北大学加齢医学研究所

    • URL

      http://www.idac.tohoku.ac.jp/index.ja.php

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所分子腫瘍学研究分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/molonc/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2022-09-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi