| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Autophagy, found by Dr. Ohsumi who won the 2016 Nobel Prize in Physiology or Medicine, is a cellular degradation system that can be induced by stress such as starvation. When cells are starved, part of cytosol and organelles are degraded and recycles to survive by forming organelles called "autophagosomes". Autophagosomes have a diameter of 1um and do not always exist in the cell, they forms when degradation is required. It has been over 20 years since autophagy related genes were identified yet how the autophagosomes are formed is unclear. Aim of this research is to characterize how the autohpagosome forms in detail.
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