| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
The animal-vegetal (A-V) axis is already set in unfertilized eggs. It plays crucial roles to coordinate germ-layer formation. However, how the A-V axis is set has not been well studied. In this study, we investigated mechanisms of how A-V axis is set in ascidians and larvaceans. Especially we show that, in ascidians, when the germinal vesicle of full-grown oocytes were experimentally translocated to the opposite pole by centrifugal force, every aspect that designates A-V polarity was reversed in the eggs and embryos. This is the first report in which the A-V axis was experimentally and completely reversed in animal oocytes before fertilization.
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