• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neural mechanism for the switching courtship and aggression

Research Project

Project/Area Number 15H04397
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTohoku University

Principal Investigator

Koganezawa Masayuki  東北大学, 生命科学研究科, 准教授 (10302085)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsショウジョウバエ / 求愛行動 / 攻撃行動 / fruitless / doublesex / 求愛 / 攻撃
Outline of Final Research Achievements

Sex differentiation of the central nervous system in Drosophila is controlled by the function of genes named fruitless (fru) and doublesex (dsx). Sexually dimorphic neural circuitry plays an important role in the execution of courtship and aggression. In this study, we focused on the dsx-expressing pC1 neurons. These neurons can be divided into two groups based on the presence or absence of fru expression. Using the activity manipulation experiments, we revealed that fru-positive subset of pC1 neurons were responsible for commanding courtship behavior, on the other hands, fru-negative subset of pC1 neurons were the commanding neurons for aggressive behavior.

Academic Significance and Societal Importance of the Research Achievements

本研究により今まで不明であった攻撃行動の司令ニューロンシステムを同定することができた。また求愛と攻撃という行動が相反して生ずることの基盤として、GABA作動性抑制性ニューロンによる司令ニューロンシステムへの抑制が重要であることも明らかとできた。このような抑制性ニューロンの機能はショウジョウバエ以外の動物でも相反的行動の実現に機能している可能性がある。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (44 results)

All 2019 2018 2017 2016 2015

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 9 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (33 results) (of which Int'l Joint Research: 11 results,  Invited: 2 results)

  • [Journal Article] Calmodulin-binding transcription factor shapes the male courtship song in Drosophila2019

    • Author(s)
      Sato Kosei、Ahsan Md. Tanveer、Ote Manabu、Koganezawa Masayuki、Yamamoto Daisuke
    • Journal Title

      PLOS Genetics

      Volume: 15 Issue: 7 Pages: e1008309-e1008309

    • DOI

      10.1371/journal.pgen.1008309

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antennae sense heat stress to inhibit mating and promote escaping in Drosophila females.2018

    • Author(s)
      Yusuke Miwa, Masayuki Koganezawa & Daisuke Yamamoto
    • Journal Title

      J Neurogenet.

      Volume: 32 Issue: 4 Pages: 353-363

    • DOI

      10.1080/01677063.2018.1513507

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants.2016

    • Author(s)
      Yilmazer YB, Koganezawa M, Sato K, Xu J, Yamamoto D.
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 13792-13792

    • DOI

      10.1038/ncomms13792

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The neural circuitry that functions as a switch for courtship versus aggression in Drosophila males2016

    • Author(s)
      Masayuki Koganezawa, Ken-ichi Kimura and Daisuke Yamamoto
    • Journal Title

      Current Biology

      Volume: in press Issue: 11 Pages: 1395-1403

    • DOI

      10.1016/j.cub.2016.04.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The neural circuitry that functions as a switch for courtship versus aggression in Drosophila males2016

    • Author(s)
      Koganezawa M., Kimura K., Yamamoto D.
    • Journal Title

      Curr. Biol.

      Volume: 26

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Requirement of the Tec family tyrosine kinase Btk29A for courtship memory in Drosophila males.2016

    • Author(s)
      Sunouchi, K. Koganezawa, M. and Yamamoto, D.
    • Journal Title

      Arch. Insect Biochem. Physiol.

      Volume: 91 Issue: 3 Pages: 165-174

    • DOI

      10.1002/arch.21316

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Zeste tunes the timing of ecdysone actions in triggering programmed tissue degeneration in Drosophila2015

    • Author(s)
      Goto T., Sato K., Sone H., Koganezawa M., Ito H., Yamamoto D.
    • Journal Title

      J. Neurogenet.

      Volume: 29 Issue: 4 Pages: 169-173

    • DOI

      10.3109/01677063.2015.1098638

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles2015

    • Author(s)
      Hara Y., Koganezawa M., Yamamoto D.
    • Journal Title

      J. Neurogenet.

      Volume: 29 Issue: 2-3 Pages: 117-123

    • DOI

      10.3109/01677063.2015.1054991

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drosophila ovipositor extension in mating behavior and egg deposition involves distinct sets of brain interneurons2015

    • Author(s)
      Ken-ichi Kimura, Chiaki Sato, Masayuki Koganezawa, Daisuke Yamamoto
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 5 Pages: e0126445-e0126445

    • DOI

      10.1371/journal.pone.0126445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ショウジョウバエの求愛行動(上)求愛を制御するフェロモン2015

    • Author(s)
      小金澤雅之
    • Journal Title

      現代化学

      Volume: 530 Pages: 48-50

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ショウジョウバエの求愛行動(下)脳の性差をつくる分子・愛を生み出す神経2015

    • Author(s)
      小金澤雅之
    • Journal Title

      現代化学

      Volume: 531 Pages: 52-55

    • Related Report
      2015 Annual Research Report
  • [Presentation] 婚姻贈呈行動に関わるショウジョウバエ脳内ニューロン2019

    • Author(s)
      小金澤雅之・鈴木拓也・山元大輔
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The effects of serotonin and dopamine to the experience dependent courtship in Drosophila2018

    • Author(s)
      Koganezawa, M.
    • Organizer
      新学術領域「人工知能と脳科学」「適応回路シフト」合同領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Drosophila subobscura 求愛時の婚姻贈呈に関わるニューロン2018

    • Author(s)
      小金澤雅之・山元大輔
    • Organizer
      平成30年度日本動物学会東北支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ショウジョウバエ種特異的求愛行動パターンを生み出す脳内介在ニューロン2018

    • Author(s)
      小金澤雅之・山元大輔
    • Organizer
      第89回日本動物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A brain interneuron shaping the species-specific courtship pattern in Drosophila2018

    • Author(s)
      小金澤 雅之・鈴木拓也・山元 大輔
    • Organizer
      日本比較生理生化学会第40回神戸大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Imprinting of social experience via serotonin to the courtship releasing mechanism of Drosophila2018

    • Author(s)
      Koganezawa, M.
    • Organizer
      新学術領域「適応回路シフト」第8回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] Ca2+ imaging analysis of doublesex-expressing neurons in Drosophila.2017

    • Author(s)
      Koganezawa, M. and Ymamoto, D.
    • Organizer
      新学術研究領域「適応回路シフト」領域会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ca2+ imaging study of courtship and aggression triggering center in Drosophila.2017

    • Author(s)
      小金澤 雅之・山元 大輔
    • Organizer
      日本比較生理生化学会第39回福岡大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Searching for neurons controlling sexual receptivity in Drosophila females.2017

    • Author(s)
      Miwa, Y., Koganezawa, M. and Yamamoto, D.
    • Organizer
      Neurobiology of Drosophila
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] doublesex発現ニューロンの性的指向性に関するCa2+イメージング解析2017

    • Author(s)
      小金澤 雅之・山元 大輔
    • Organizer
      日本動物学会第88回富山大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエ求愛・攻撃中枢のCa2+イメージング解析2017

    • Author(s)
      小金澤 雅之・山元 大輔
    • Organizer
      日本動物学会平成29年度東北支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエ求愛解発機構に対するセロトニンによる社会的経験の刻印2017

    • Author(s)
      小金澤 雅之・山元 大輔
    • Organizer
      新学術領域「適応回路シフト」第5回領域班会議
    • Related Report
      2017 Annual Research Report
  • [Presentation] セロトニンによるショウジョウバエ経験依存的求愛行動の調節とその神経基盤2016

    • Author(s)
      小金澤雅之
    • Organizer
      新学術領域「適応回路シフト」第4回領域会議
    • Place of Presentation
      学術総合センター(東京都)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sexually dimorphic neural circuitry that functions as a switch for courtship versus aggression in Drosophila.2016

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      The 22nd International Congress of Zoology
    • Place of Presentation
      OIST&OCC(沖縄県)
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 求愛と攻撃の相反性を実現するショウジョウバエ脳内神経回路2016

    • Author(s)
      小金澤雅之
    • Organizer
      2016年度行動遺伝学研究会「個体の繋がりの分子進化研究」
    • Place of Presentation
      国立遺伝学研究所(静岡県)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Central brain neurons controlling courtship and aggression in Drosophila melanogaster.2016

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      JSCPB 2016 Tokyo(日本比較生理生化学会第38回年会)
    • Place of Presentation
      玉川大学(東京都)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] ショウジョウバエの攻撃と求愛の切替を行う脳内神経回路2016

    • Author(s)
      小金澤雅之・山元大輔
    • Organizer
      平成28年度日本動物学会東北支部大会
    • Place of Presentation
      福島県立医科大学(福島県)
    • Year and Date
      2016-08-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] ショウジョウバエの経験依存的求愛行動に関わる外的・内的要因2016

    • Author(s)
      小金澤雅之
    • Organizer
      新学術領域「適応回路シフト」第3回領域会議
    • Place of Presentation
      ホテルリステル猪苗代(福島県)
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] The neural switch for courtship versus aggression in Drosophila.2016

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      Environmental Sensing and Animal Behavior
    • Place of Presentation
      東京大学(東京都)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Searching for ppk-expressing neurons that control female receptivity in Drosohila2016

    • Author(s)
      Miwa Y., Koganezawa M., Emoto K., Yamamoto D.
    • Organizer
      日本昆虫学会第76回大会・第60回日本応用動物昆虫学会大会合同大会
    • Place of Presentation
      大阪府立大学(大阪)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Manipulating ppk-expressing neurons yields a post-mating-like behavior in Drosophila females2016

    • Author(s)
      Miwa Y., Koganezawa M., Emoto K., Yamamoto D.
    • Organizer
      International Symposium on Adaptive Circuit Shift 2016
    • Place of Presentation
      Doshisha University (Kyoto, Japan)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエの求愛と攻撃を切り替える神経機構2015

    • Author(s)
      小金澤雅之
    • Organizer
      新学術領域「適応回路シフト」第2回領域会議
    • Place of Presentation
      東京医科歯科大学(東京)
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] GABAergic neural circuitry controlling courtship and aggression in Drosophila2015

    • Author(s)
      Koganezawa, M., Yamamoto, D.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting “Joy of Brain”
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sex-specific cleavage of lola specifies sex-specific neurite structures in Drosohila2015

    • Author(s)
      Sato, K., Ito, H., Koganezawa, M., Toba, G., Yamamoto, D.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting “Joy of Brain”
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Doublesex expressing neurons that contribute to copulation in Drosophila2015

    • Author(s)
      Yilmazer, Y. Koganezawa, M. Yamamoto, D.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting “Joy of Brain”
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Select ppk-expressing neurons control female sexual receptivity in Drosophila2015

    • Author(s)
      Miwa, Y., Koganezawa, M., Emoto, K., Yammaoto, D.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting “Joy of Brain”
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of social experience on inter-male courtship in Drosophila fruitless mutants2015

    • Author(s)
      Takei, T., Koganezawa, M., Yamamoto, D.
    • Organizer
      NTNU-Tohoku Univ. Brain Science Meeting “Joy of Brain”
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Male-specific transcription factor Fruitless non-transcriptionally suppresses proteolytic cleavage of a Lola isoform to generate sexual differences in neuronal structures and behavior of Drosophila2015

    • Author(s)
      Sato, K. Ito, H. Koganezawa, M. and Yamamoto, D.
    • Organizer
      Neurobiology of Drosophila. Cold Spring Harbor Laboratory, USA
    • Place of Presentation
      Cold Spring Harbor Laboratory (Cold Spring Harbor, USA)
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエの求愛と攻撃を解発する脳内fru/dsx発現ニューロン2015

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟コンベンションセンター(新潟)
    • Year and Date
      2015-09-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショウジョウバエの攻撃を解発する脳内ニューロン2015

    • Author(s)
      小金澤雅之, 山元大輔
    • Organizer
      平成27年度日本動物学会東北支部大会
    • Place of Presentation
      東北大学(宮城)
    • Year and Date
      2015-08-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショウジョウバエ求愛行動の神経基盤とその経験依存的指向性シフト2015

    • Author(s)
      小金澤雅之
    • Organizer
      新学術領域「適応回路シフト」第1回領域会議
    • Place of Presentation
      グランデコ(福島)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショウジョウバエ求愛行動を司る中枢ニューロン2015

    • Author(s)
      小金澤雅之
    • Organizer
      新学術領域「適応回路シフト」第1回領域会議
    • Place of Presentation
      グランデコ(福島)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Possible involvement of neuropeptide-expressing neurons in the regulation of female receptivity2015

    • Author(s)
      Miwa Y., Koganezawa M., Emoto K., Yamamoto D.
    • Organizer
      The 3rd Asia-Pacific Drosophila Research Conference
    • Place of Presentation
      Beijing Conference Center (Beijing, China)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2022-11-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi