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Elucidation of odor representation in insects through a detailed modeling of insect olfactory network

Research Project

Project/Area Number 15H04399
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

Kanzaki Ryohei  東京大学, 先端科学技術研究センター, 教授 (40221907)

Co-Investigator(Renkei-kenkyūsha) KAZAWA Tomoki  東京大学, 先端科学技術研究センター, 特任研究員 (00507824)
SAKURAI Takeshi  東京大学, 先端科学技術研究センター, 特任講師 (20506761)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords脳・神経 / シミュレーション / 遺伝子 / データ同化 / 昆虫
Outline of Final Research Achievements

In this study, we aimed to understand neural mechanisms to process dynamically changing pheromone information in the antennal lobe of male silkmoths. We generated several transgenic silkmoth lines that are useful for investigating functional connectivity of neurons in the antennal lobe of silkmoths. Based on experimental data, we constructed single compartment and multi-compartment simulation models of the antennal lobe of male silkmoths. We demonstrated that these simulation models can reproduce experimentally observed phenomena such as modulation of pheromone responses of the antennal lobe projection neurons to successive pheromone stimuli or by mechanosensory input to antennae.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (57 results)

All 2018 2017 2016 2015 Other

All Journal Article (14 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (41 results) (of which Int'l Joint Research: 17 results,  Invited: 20 results) Remarks (2 results)

  • [Journal Article] The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori2017

    • Author(s)
      Namiki S, Fujii T, Shimada T, Kanzaki R
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 14050-14050

    • DOI

      10.1038/s41598-017-14578-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refinement of ectopic protein expression through the GAL4/UAS system in Bombyx mori: application to behavioral and developmental studies2017

    • Author(s)
      6.Hara C, Morishita K, Takayanagi-Kiya S, Mikami A, Uchino K, Sakurai T, KanzakiR, Sezutsu H, Iwami M, Kiya T
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11796-11796

    • DOI

      10.1038/s41598-017-12102-2

    • NAID

      120006370943

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 匂いセンサカイコガ開発の可能性2017

    • Author(s)
      櫻井健志,光野秀文,神崎亮平
    • Journal Title

      アグリバイオ

      Volume: 1 Pages: 641-646

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Morphology and physiology of antennal lobe projection neurons in the hawkmoth Agrius convolvuli2017

    • Author(s)
      Nirazawa T, Fujii T, Seki Y, Namiki S, Kazawa T, Kanzaki R, Ishikawa Y
    • Journal Title

      Journal of Insect Physiology

      Volume: 98 Pages: 214-222

    • DOI

      10.1016/j.jinsphys.2017.01.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of repellent odorants to the body louse, Pediculus humanus corporis, in clove essential oil.2016

    • Author(s)
      Iwamatsu T., Miyamoto D., Mitsuno H., Yoshioka Y., Fujii T., Sakurai T., Ishikawa Y., Kanzaki R.
    • Journal Title

      Parasitol Research

      Volume: 4 Issue: 4 Pages: 1659-1666

    • DOI

      10.1007/s00436-016-4905-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Response prediction of an insect’s olfactory receptor neuron by using structural parameters of odorant and Self-Organizing Map2016

    • Author(s)
      Yuki Harada, Kazawa Tomoki, Ryohei Kanzaki, Takamichi Nakamoto
    • Journal Title

      IEEE Sensors Journal

      Volume: 16 Issue: 3 Pages: 580-585

    • DOI

      10.1109/jsen.2015.2487820

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neurobiological basis of orientation in insects: insights from the silkmoth mating dance2016

    • Author(s)
      Namiki Shigehiro、Kanzaki Ryohei
    • Journal Title

      Current Opinion in Insect Science

      Volume: 15 Pages: 16-26

    • DOI

      10.1016/j.cois.2016.02.009

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative neuroanatomy of the lateral accessory lobe in the insect brain2016

    • Author(s)
      Shigehiro Namiki, Ryohei Kanzaki
    • Journal Title

      Frontiers in Physiology

      Volume: 7 Pages: 244-244

    • DOI

      10.3389/fphys.2016.00244

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 昆虫の匂い源探索を担う神経基盤2016

    • Author(s)
      並木重宏,神崎亮平
    • Journal Title

      アロマリサーチ

      Volume: 17 Pages: 37-41

    • NAID

      40020750085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 虫の匂い源探索を司令する中枢2016

    • Author(s)
      並木重宏,神崎亮平
    • Journal Title

      昆虫と自然

      Volume: 51 Pages: 23-26

    • NAID

      40021029705

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 昆虫の匂い源探索を担う神経基盤2016

    • Author(s)
      並木重宏、神崎亮平
    • Journal Title

      アロマリサーチ

      Volume: 17 Pages: 16-26

    • NAID

      40020750085

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two types of local interneurons are distinguished by morphology, intrinsic membrane properties, and functional connectivity in the moth antennal lobe.2015

    • Author(s)
      Masashi Tabuchi1, Li Dong, Shigeki Inoue, Shigehiro Namiki, Takeshi Sakurai, Kei Nakatani, and Ryohei Kanzaki
    • Journal Title

      Journal of Neurophysiology

      Volume: 114 Issue: 5 Pages: 3002-3013

    • DOI

      10.1152/jn.00050.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Toward the Whole Brain Simulation of Insect Brain2015

    • Author(s)
      加沢知毅、宮本大輔、後藤晃彦、朴希原、福田哲也、神崎亮平
    • Journal Title

      The Brain & Neural Networks

      Volume: 22 Issue: 3 Pages: 89-102

    • DOI

      10.3902/jnns.22.89

    • NAID

      130005106193

    • ISSN
      1340-766X, 1883-0455
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 昆虫嗅覚系全脳シミュレーションに向けて: スーパコンピュータによる大規模脳シミュレーションの現在とその展望2015

    • Author(s)
      宮本大輔、加沢知毅、神崎亮平
    • Journal Title

      人工知能学会誌

      Volume: 30 Pages: 630-638

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 雄カイコガの触角応答キネティクスと効率的なフェロモン源探索行動の解析2018

    • Author(s)
      塩田裕介, 櫻井健志, 安藤規泰, 光野秀文, 大門高明,神崎亮平
    • Organizer
      第62回日本応用動物昆虫学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エビガラスズメにおける近縁種の性フェ ロモンの情報処理機構2018

    • Author(s)
      韮澤拓也,並木重宏,関洋一,藤井毅,石川幸男,加沢知毅,神崎亮平
    • Organizer
      第62回日本応用動物昆虫学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Novel Technology Innovated by Insect Sciences2017

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      University of Cambridge-The University of Tokyo Joint Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Super-Sensing Learned from Insect Sciences2017

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      THE AGE OF SUPER SENSING 2017 International Conference on Advanced Sensing Design and Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The experimental-data-driven construction of neural circuit simulation of insect brain using estimations on a single neuron and circuit level2017

    • Author(s)
      2.Kazawa T, Arase J, Fukuda T, Park H, Miyamoto D and Kanzaki
    • Organizer
      Advances in Neuroinfomatics 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accuracy and flexibility in odour plume tracking of insects2017

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      第40回神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 生物に学ぶ先端技術の未来2017

    • Author(s)
      神崎亮平
    • Organizer
      2017年度前期「イノベーションフォーラム21」第5回
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Molecular and neural mechanisms underlying efficient pheromone source localization in the silkmoth Bombyx mori2017

    • Author(s)
      櫻井健志,塩田裕介,神崎亮平
    • Organizer
      第39回日本比較生理生化学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ガ類のフェロモン選好性を決める神経回路2017

    • Author(s)
      並木重宏,神崎亮平
    • Organizer
      日本進化学会第19回大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Difference of the neural pathways between the sex pheromone and behavioral antagonist in the hawkmoth, Agrius conbolvuili2017

    • Author(s)
      Nirazawa T,Namiki S, Seki Y, Fujii T, Ishikawa Y, Kazawa T, Kanzaki R
    • Organizer
      第39回日本比較生理生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of relationship between antennal response kinetics and pheromone source localization efficiency in pheromone binding protein knockout silkmoth, Bombyx mori2017

    • Author(s)
      Shiota Y, Sakurai T, Ando N, Mitsuno H, Daimon T, Kanzaki R
    • Organizer
      第39回日本比較生理生化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Future Technology: Learning from Biological Systems2017

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      Supersensing Forum Design and Technology Mdeled on Biological Systems Organized
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝子組換えカイコガを利用したフェロモン受容体遺伝子の発現制御領域の探索2017

    • Author(s)
      櫻井健志,田渕理史,内野恵郎,瀬筒秀樹,神崎亮平
    • Organizer
      第61回日本応用動物昆虫学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] フェロモン結合タンパク質遺伝子ノックアウトカイコガの神経生理応答のキネティクス・フェロモン源探索行動解析2017

    • Author(s)
      塩田裕介,櫻井健志,安藤規泰,光野秀文,神崎亮平
    • Organizer
      第61回日本応用動物昆虫学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 昆虫の嗅覚を再現した匂いセンサと匂い源探索ロボット2016

    • Author(s)
      神崎亮平
    • Organizer
      未来ICTシンポジウム2016
    • Place of Presentation
      東京ビッグサイト、東京
    • Year and Date
      2016-01-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 昆虫に潜む能力を活かす-遺伝子から鼻を,ニューロンから脳を再現する-2016

    • Author(s)
      神崎亮平
    • Organizer
      第4回生物の優れた機能から着想を得た新しいものづくりシンポジウム
    • Place of Presentation
      京都工芸繊維大学、京都
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Super-Sensing and Processing for adaptability (intelligence) New Science and Technology Innovated by Insect Sciences2016

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      2016 International Symposium on Convergence Technologies “Education and Cooperation for Convergence”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Brain-Machine Integrated System2016

    • Author(s)
      Ryohei Kanzaki
    • Organizer
      International Symposium on Advanced Manufacturing Science for Future Systems “Biomimetics”
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Peripheral coding of sex-pheromone blend by male-specific odorant receptors in moth2016

    • Author(s)
      Hidefumi Mitsuno, Takeshi Sakurai, Ryohei Kanzaki
    • Organizer
      5th Nagoya Biomimetics International Symposium
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of an olfactory receptor for DEET in the body louse, Pediculus humanus corporis2016

    • Author(s)
      Takuma Iwamatsu, Hidefumi Mitsuno, Daisuke Miyamoto, Takeshi Sakurai, Ryohei Kanzaki
    • Organizer
      International Symposium on Environmental Sensing and Animal Behavior
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological and behavioral analysis of pheromone binding protein gene knockout silkmoth2016

    • Author(s)
      Takeshi Sakurai, Yusuke Shiota, Takaaki Daimon, Hidefumi Mitsuno, Ryohei Kanzaki
    • Organizer
      The 17th International Symposium of Olfaction and Taste
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PhOR3 contributes to the reception of DEET in body lice, Pediculus humanus corporis2016

    • Author(s)
      Takuma Iwamatsu, Hidefumi Mitsuno, Daisuke Miyamoto, Takeshi Sakura, Ryohei Kanzaki
    • Organizer
      The 17th International Symposium of Olfaction and Taste
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昆虫科学が拓くあたらしい科学と技術~ センサ、脳を創り、理解し、活用する ~2016

    • Author(s)
      神崎亮平
    • Organizer
      SCI-TECH SALON(サイエンステクノフロンティアフォーラム)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Temporal kinetics analysis of pheromone responses of pheromone binding protein knockout silkmoth, Bombyx mori2016

    • Author(s)
      Yusuke Shiota, Takeshi Sakurai, Noriyasu Ando, Takaaki Daimon, Ryohei Kanzaki
    • Organizer
      第38回日本比較生理生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of the olfactory receptor related to the reception of DEET in the body louse, Pediculus humanus corporis2016

    • Author(s)
      Takuma Iwamatsu, Hidefumi Mitsuno, Daisuke Miyamoto, Takeshi SakuraiI, Ryohei Kanzaki
    • Organizer
      第38回日本比較生理生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Morphology and physiology of antennal lobe projection neurons in sweet potato hornworm, Agrius convolvuli2016

    • Author(s)
      Takuya Nirazawa, Takeshi Fujii, Yoichi Seki, Shigehiro Namiki, Tomoki Kazawa, Ryohei Kanzaki, Yukio Ishikawa
    • Organizer
      第38回日本比較生理生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Multi-color calcium imaging to understand odor processing in insect antennal lobe2016

    • Author(s)
      Hiroaki Yamazaki, Tomoki Kazawa, Ryohei Kanzaki
    • Organizer
      第38回日本比較生理生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Developing tools towards the olfactory system simulation of silkmoth2015

    • Author(s)
      Yamzaki H, Kazawa T, Kanzaki R
    • Organizer
      CompBiol 2015広島大会
    • Place of Presentation
      広島アステールプラザ、広島
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Establishment and behavioral analysis of pheromone binding protein gene knockout silkmoth2015

    • Author(s)
      Sakurai T, Shiota Y, Daimon T, Mitsuno H, Kanzaki R
    • Organizer
      CompBiol 2015広島大会
    • Place of Presentation
      広島アステールプラザ、広島
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] A method for construction and application of standard brain model based on the confocal images2015

    • Author(s)
      Ikeno H, Miyamoto D, Kazawa T, Kanzaki R
    • Organizer
      Advances in Neuroinformatics 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Invertebrate Brain Platform (IVB-PF) - Comparative expositions and data collection about invertebrate brain2015

    • Author(s)
      Kanzaki R, Kazawa T, Ikeno H, Miyamoto D, Yamaguchi Y
    • Organizer
      Advances in Neuroinformatics 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis and Optimization of Multi-compartment Hodgkin-Huxley Type Model Simulations for Processing with SIMD Instructions2015

    • Author(s)
      Miyamoto D, Kazawa T, Kanzaki R
    • Organizer
      Advances in Neuroinformatics 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Construct learning Neural Network with biophysically detailed multi-compartment model2015

    • Author(s)
      Kazawa T, Goto A, Miyamoto D, Kanzaki R
    • Organizer
      Advances in Neuroinformatics 2015
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昆虫に潜む能力を生かす-遺伝子から鼻を,ニューロンから脳を再現する-2015

    • Author(s)
      神崎亮平
    • Organizer
      電子情報技術産業協会 感性センシング応用ロードマップ技術分科会
    • Place of Presentation
      電子情報技術産業協会、東京
    • Year and Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 遺伝子から鼻を,ニューロンから脳を再現する2015

    • Author(s)
      神崎亮平
    • Organizer
      日本オプトメカトロニクス協会 平成27年度第2回技術部会活動
    • Place of Presentation
      東京大学先端科学技術研究センター、東京
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] マルチコンパートメント詳細モデルによる学習する神経回路の構築2015

    • Author(s)
      福田哲也、宮本大輔、神崎亮平、加沢知毅
    • Organizer
      第25回 日本神経回路学会
    • Place of Presentation
      電気通信大学、調布
    • Year and Date
      2015-09-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Neural Basis of Pheromone Orientation in the Silkmoth: from genes, neural networks, and behavior to robots2015

    • Author(s)
      Kanzaki R
    • Organizer
      The 9th International Congress of Comparative Physiology and Biochemistry
    • Place of Presentation
      Krakow, Poland
    • Year and Date
      2015-08-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Realistic neural circuit simulation of the moth antennal lobe that recognizes relative pheromonal concentration2015

    • Author(s)
      Park H, Kazawa T, Goto A, Miyamoto D, Tabuchi M, Kanzaki R
    • Organizer
      8th INCF Congress in Neuroinformatics 2015
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昆虫科学が拓く新しい工学:昆虫のセンサと脳の再現による理解と工学応用2015

    • Author(s)
      神崎亮平
    • Organizer
      JBAバイオセミナーシリーズ“未来へのバイオ技術”勉強会 バイオロボティクス
    • Place of Presentation
      バイオインダストリー協会、東京
    • Year and Date
      2015-08-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Neural Basis of Odor Navigation in Insects: From Genes, Neural Networks and Behavior to Robots. Neuroethology2015

    • Author(s)
      Kanzaki R
    • Organizer
      Neuroethology: Behavior, Evolution & Neurobiology: Gordon Research Conferences
    • Place of Presentation
      Renaissance Tuscany Il Ciocco Lucca (Barga), Italy
    • Year and Date
      2015-06-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 昆虫の嗅覚機構を再現した匂いセンサと匂い源探索ロボットー遺伝子から鼻を,ニューロンから脳を再現するー2015

    • Author(s)
      神崎亮平
    • Organizer
      精密工学会 知的ナノ計測専門委員会特別講演
    • Place of Presentation
      東京大学先端科学技術研究センター、東京
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Remarks] 東京大学先端科学技術研究センター 生命知能システム分野 神崎・高橋研究室

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター 生命知能システム分野 神崎・高橋研究室

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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