| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
The inconsistency between Papua New Guinea Highlanders' protein-deficient diet and their muscular physique is well known. Moreover, although their protein intake is less than biologically adequate, protein-deficiency related disorders have rarely been reported in this setting. We have speculated that the populace have adapted to a low-protein diet by utilizing air nitrogen fixed by intestinal bacteria and/or by intensive "recycling" of urea that passes into the gastrointestinal tract. The recent emergence of genome science have enabled us to examine the unsolved question of Papua New Guinea Highlanders' adaptation to a low protein diet in more direct way. In our project, we evaluated gut microbiota for individuals in four Papua New Guinea communities subject to different degrees of protein deficiency. Animal experiments were also conducted. Association of gut microbiota and variation of protein intake and nutritional biomarkers were investigated.
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