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Physiological polymorphism on Wnt signal and bone-vessel association

Research Project

Project/Area Number 15H04432
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied anthropology
Research InstitutionNagasaki University

Principal Investigator

AOYAGI Kiyoshi  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)

Co-Investigator(Kenkyū-buntansha) 有馬 和彦  長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
前田 隆浩  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
西村 貴孝  長崎大学, 医歯薬学総合研究科(医学系), 助教 (80713148)
安部 恵代  長崎大学, 医歯薬学総合研究科(医学系), 准教授 (90372771)
富田 義人  長崎大学, 医歯薬学総合研究科(医学系), 助教 (40779584)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords生理的多型性 / 骨粗鬆症 / 動脈硬化 / 骨・血管連関 / 骨量 / スクレロスチン / 動脈硬化症
Outline of Final Research Achievements

We aimed to clear the effect of sclerostin adjusting Wnt signal to the association between bone and blood vessel. The subjects were community-dwelling men (n=446) and women (n=689), and their bone mass and index of arteriosclerosis were measured. In results, after adjusting confounding factors, a higher level of sclerostin was significantly correlated with a higher bone mass in both sexes, and a higher bone mass was significantly correlated with a higher index of arteriosclerosis.

Academic Significance and Societal Importance of the Research Achievements

男女ともにスクレロスチンと骨量は正の関連を示したが、その関連は男性のほうがやや強い関連を示した。一方で、先行研究とは異なり、スクレロスチンと動脈硬化指数に有意な関連はなかった。本研究は、骨・血管連関の生理的多型性をWntシグナルのメカニズムを通して解明を試みたものであり、人類学的に意義がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 4 results) Remarks (1 results)

  • [Journal Article] Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in middle-aged and elderly Japanese men2018

    • Author(s)
      Nishimura Takayuki、Arima Kazuhiko、Abe Yasuyo、Kanagae Mitsuo、Mizukami Satoshi、Okabe Takuhiro、Tomita Yoshihito、Goto Hisashi、Horiguchi Itsuko、Aoyagi Kiyoshi
    • Journal Title

      Medicine

      Volume: 97 Issue: 8 Pages: e9962-e9962

    • DOI

      10.1097/md.0000000000009962

    • NAID

      120006987315

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of fear of falling and associated factors among Japanese community-dwelling older adults2018

    • Author(s)
      Tomita Yoshihito、Arima Kazuhiko、Tsujimoto Ritsu、Kawashiri Shin-ya、Nishimura Takayuki、Mizukami Satoshi、Okabe Takuhiro、Tanaka Natsumi、Honda Yuzo、Izutsu Kazumi、Yamamoto Naoko、Ohmachi Izumi、Kanagae Mitsuo、Abe Yasuyo、Aoyagi Kiyoshi
    • Journal Title

      Medicine

      Volume: 97 Issue: 4 Pages: e9721-e9721

    • DOI

      10.1097/md.0000000000009721

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of vertebral compression fractures with physical performance measures among community-dwelling Japanese women aged 40 years and older.2017

    • Author(s)
      Arima K, Abe Y, Nishimura T, Okabe T, Tomita Y, Mizukami S, Kanagae M, Aoyagi K.
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 18 Issue: 1 Pages: 176-176

    • DOI

      10.1186/s12891-017-1531-3

    • NAID

      120006987518

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-specific risk factors for incident disability in activities of daily living among middle-aged and elderly community-dwelling Japanese women during an 8-9-year follow up: The Hizen-Oshima study.2017

    • Author(s)
      Okabe T, Abe Y, Tomita Y, Mizukami S, Kanagae M, Arima K, Nishimura T, Tsujimoto R, Tanaka N, Goto H, Horiguchi I, Aoyagi K.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 17 Issue: 7 Pages: 1096-1101

    • DOI

      10.1111/ggi.12834

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over2016

    • Author(s)
      Abe Y, Nishimura T, Arima K, Kanagae M, Mizukami S, Tomita Y, Okabe T, Goto H, Horiguchi I, Aoyagi K
    • Journal Title

      J Physiol Anthropol

      Volume: 35 Issue: 1 Pages: 25-25

    • DOI

      10.1186/s40101-016-0114-6

    • NAID

      120006987448

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women2016

    • Author(s)
      Tsujimoto R, Abe Y, Arima K, Nishimura T, Tomita M, Yonekura A, Miyamoto T, Matsubayashi S, Tanaka N, Aoyagi K
    • Journal Title

      BMC Musculoskelet Disord

      Volume: 17 Issue: 1 Pages: 493-493

    • DOI

      10.1186/s12891-016-1343-x

    • NAID

      120006987612

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men2015

    • Author(s)
      Nishimura T, Arima K, Abe Y, Kanagae M, Mizukami S, Okabe T, Tomita Y, Goto H, Horiguchi I, Aoyagi K
    • Journal Title

      Medicine

      Volume: 94 Issue: 44 Pages: 1797-1797

    • DOI

      10.1097/md.0000000000001797

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older2015

    • Author(s)
      Tomita Y, Arima K, Kanagae M, Okabe T, Mizukami S, Nishimura T, Abe Y, Goto H, Horiguchi I, Aoyagi K
    • Journal Title

      Medicine

      Volume: 94 Issue: 35 Pages: 1449-1449

    • DOI

      10.1097/md.0000000000001449

    • NAID

      120006986851

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older.2018

    • Author(s)
      Yoshihito Tomita, Kazuhiko Arima, Mitsuo Kanagae, Takuhiro Okabe, Satoshi Mizukami, Takayuki Nishimura, Yasuyo Abe, Hisashi Goto, Itsuko Horiguchi, Kiyoshi Aoyagi
    • Organizer
      International Symposium on Physiological Anthropology (ISPA) , Kota Kinabalu, Malaysia,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prevalence of fear of falling and associated factors among Japanese community-dwelling older adults2018

    • Author(s)
      Tomita Y, Arima K, Tsujimoto R, Kawashiri S, Nishimura T, Mizukami S, Okabe T, Tanaka N, Honda Y, Izutsu K, Yamamoto N, Ohmachi I, Kanagae M, Abe Y, Aoyagi K
    • Organizer
      International Scientific Seminar Physiological Anthropology and Human Ecology, Moscow, Russia,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Moderate drinking alcohol is associate with higher bone mass in Japanese community dwelling population2018

    • Author(s)
      Kazuhiko Arima, Takayuki Nishimura, Yoshihito Tomita, Shoichi Fukui, Naoki Iwamoto, Shin-ya Kawashiri, Mami Tamai, Yasuyo Abe, Atsushi Kawakami, Kiyoshi Aoyagi
    • Organizer
      the 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2018), Kaohsiung, Taiwan
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨量関連因子の解析 長崎アイランドコホート研究骨衛生活動.2018

    • Author(s)
      有馬 和彦, 岩本 直樹, 福井 翔一, 川尻 真也, 玉井 慎美, 川上 純, 青柳 潔
    • Organizer
      日本リウマチ学会総会・学術集会プログラム・抄録集62回(東京)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 閉経後女性における主観的歩行速度と骨量との関連2018

    • Author(s)
      富田義人,有馬和彦,西村貴孝,岡部拓大,水上諭,金ケ江光生,安部恵代,本井碧,小屋松淳,山梨啓友,清水悠路,前田隆浩,青柳 潔
    • Organizer
      日本生理人類学会誌第78回大会概要集(東京)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域在住住民における飲酒習慣と骨量の関連解析2018

    • Author(s)
      有馬 和彦, 富田 義人, 西村 貴孝, 岡部 拓大, 水上 諭, 金ヶ江 光生, キット 彩乃, 長谷川 麻衣子, 宗 陽子, 後藤 尚, 安部 恵代, 青柳 潔
    • Organizer
      第77回日本公衆衛生学会総会抄録集(福島)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域在住高齢者における転倒恐怖感の関連要因2018

    • Author(s)
      富田 義人, 岡部 拓大, 水上 諭, 金ヶ江 光生, キット 彩乃, 長谷川 麻衣子, 宗 陽子, 後藤 尚, 西村 貴孝, 有馬 和彦, 安部 恵代, 青柳 潔
    • Organizer
      第77回日本公衆衛生学会総会抄録集(福島)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中年および高齢女性における低骨量と転倒・転倒恐怖感との関連2017

    • Author(s)
      富田 義人, 有馬 和彦, 西村 貴孝, 金ヶ江 光生, 安部 恵代, 青柳 潔
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 地域在住中高年者における低カルボキシル化オステオカルシンと骨量との関連2017

    • Author(s)
      田中 奈津美, 有馬 和彦, 西村 貴孝, 富田 義人, 安部 恵代, 尾崎 誠, 青柳 潔
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 地域在住高齢者における転倒恐怖感の関連要因2016

    • Author(s)
      富田義人,西村貴孝,岡部拓大,水上 諭,金ケ江光生,有馬和彦,安部恵代,後藤 尚,青柳 潔
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府・大阪市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 長崎県農村地域の中高年男性における骨量と骨代謝マーカーとの関連2016

    • Author(s)
      西村貴孝,有馬和彦,安部恵代,青柳 潔
    • Organizer
      第26回九州農村医学会
    • Place of Presentation
      沖縄県男女共同参画センターてぃるる(沖縄県・那覇市)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Association of spinal inclination and vertebral deformities with difficulties in activities of daily living2015

    • Author(s)
      Abe Y, Aoyagi K
    • Organizer
      ASBMR annual meeting
    • Place of Presentation
      Seattle, Washington, USA
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域侍従中高年女性における新規非椎体骨折2015

    • Author(s)
      安部恵代、松下雄太、西村貴孝、有馬和彦、青柳潔
    • Organizer
      第17回日本骨粗鬆症学会
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 地域在住中高年者における骨量と骨代謝マーカー及び生活習慣との関連2015

    • Author(s)
      西村貴孝、有馬和彦、安部恵代、青柳潔
    • Organizer
      日本生理人類学会第72回大会
    • Place of Presentation
      北海道大学医学部学友会館「フラテ」(北海道・札幌市)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
  • [Remarks] 長崎大学大学院医歯薬学総合研究科公衆衛生学

    • URL

      http://www.med.nagasaki-u.ac.jp/public-h/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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